Heisenberg professorship

Medicine 3

Head of Department:
Prof. Dr. med. univ. Georg Schett

The impact of fibroblasts in sclerodermia and rheumatoid arthritis

Head: Prof. Dr. med. Jörg Distler

Fibrotic diseases account for up to 45% of deaths in the developed world, yet there are almost no effective anti-fibrotic therapies for clinical use.

In our research group, we aim to investigate the molecular mechanisms underlying the aberrant tissue responses in fibrotic diseases (such as systemic sclerosis/scleroderma, chronic Graft-versus-Host-disease, pulmonary fibrosis, liver cirrhosis, renal fibrosis and hypertrophic scars) and to develop novel strategies for therapeutic intervention.

Our strategy is to identify de-regulated signaling pathways in samples of human fibrotic diseases ex vivo, to characterize their regulation and function in vitro and in vivo and to evaluate their potential for therapeutic intervention in murine models. Our evaluation included novel optical imaging strategies, which we run in close cooperation with the Max-Planck Institute of the Science of Light (Immunophysics).

Promising novel therapeutic approaches are transferred from bench-to-bedside with evaluation of the novel pharmacologic approach in clinical trials in patients with fibrotic diseases, often in cooperation with pharmaceutical industry.

Selected Publications

  • Chen CW, Beyer C, Liu J, Maier C, Li C, Trinh-Minh T, Xu X, Cole SH, Hsieh MH, Ng N, Althage A, Meeusen S, Pan S, Svensson EC, Seidel HM, Schett G, Gergely P, Harris JL, Distler JH: Pharmacological inhibition of porcupine induces regression of experimental... Ann Rheum Dis. 2017;
  • Herrick AL, Pan X, Peytrignet S, Lunt M, Hesselstrand R, Mouthon L, Silman A, Brown E, Czirják L, Distler JH, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk M, Ancu?a C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt Ø, Jordan AC, Jobanputra P, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov N, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, MacGregor AJ, McHugh N, Müller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, ?nanç M, McLaren JS, van Laar JM, Pathare S, Proudman S, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Denton CP: Treatment outcome in early diffuse cutaneous systemic sclerosis: the European... Ann Rheum Dis. 2017;
  • Maier C, Ramming A, Bergmann C, Weinkam R, Kittan N, Schett G, Distler JH, Beyer C: Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by... Ann Rheum Dis. 2017;
  • Palumbo-Zerr K, Soare A, Zerr P, Liebl A, Mancuso R, Tomcik M, Sumova B, Dees C, Chen CW, Wohlfahrt T, Mallano T, Distler A, Ramming A, Gelse K, Mihai C, Distler O, Schett G, Distler JH: Composition of TWIST1 dimers regulates fibroblast activation and tissue... Ann Rheum Dis. 2017;76(1): 244-251
  • López-Isac E, Bossini-Castillo L, Palma AB, Assassi S, Simeón CP, Ortego-Centeno N, Vicente E, Tolosa C, Rubio-Rivas M, Román-Ivorra JA, Spanish Scleroderma Group , Beretta L, Moroncini G, Hunzelmann N, Distler JH, Riemekasten G, de Vries-Bouwstra J, Voskuyl AE, Radstake TR, Herrick A, Denton CP, Fonseca C, Mayes MD, Martín J: Analysis of ATP8B4 F436L missense variant in a large Systemic sclerosis cohort. Arthritis Rheumatol. 2017;
  • Bergmann C, Distler JH: Epigenetic factors as drivers of fibrosis in systemic sclerosis. Epigenomics. 2017;9(4): 463-477
  • Kopp C, Beyer C, Linz P, Dahlmann A, Hammon M, Jantsch J, Neubert P, Rosenhauer D, Müller DN, Cavallaro A, Eckardt KU, Schett G, Luft FC, Uder M, Distler JH, Titze J: Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by... Rheumatology (Oxford). 2017;56(4): 674
  • Liang R, ?umová B, Cordazzo C, Mallano T, Zhang Y, Wohlfahrt T, Dees C, Ramming A, Krasowska D, Michalska-Jakubus M, Distler O, Schett G, ?enolt L, Distler JH: The transcription factor GLI2 as a downstream mediator of transforming growth... Ann Rheum Dis. 2016;
  • Elhai M, Avouac J, Walker UA, Matucci-Cerinic M, Riemekasten G, Airò P, Hachulla E, Valentini G, Carreira PE, Cozzi F, Balbir Gurman A, Braun-Moscovici Y, Damjanov N, Ananieva LP, Scorza R, Jimenez S, Busquets J, Li M, Müller-Ladner U, Kahan A, Distler O, Allanore Y, EUSTAR co-authors , Guiducci S, Tyndall A, Lapadula G, Iannone F, Becvar R, Sierakowsky S, Bielecka OK, Cutolo M, Sulli A, Cuomo G, Vettori S, Rednic S, Nicoara I, Vlachoyiannopoulos P, Montecucco C, Caporali R, Novak S, Czirják L, Varju C, Chizzolini C, Kucharz EJ, Kotulska A, Kopec-Medrek M, Widuchowska M, Rozman B, Mallia C, Coleiro B, Gabrielli A, Farge D, Hij A, Hesselstrand R, Scheja A, Wollheim F, Martinovic D, Govoni M, Monaco AL, Hunzelmann N, Pellerito R, Bambara LM, Caramaschi P, Black C, Denton C, Henes J, Santamaria VO, Heitmann S, Krasowska D, Seidel M, Oleszowsky M, Burkhardt H, Himsel A, Salvador MJ, Stamenkovic B, Stankovic A, Tikly M, Starovoytova MN, Engelhart M, Strauss G, Nielsen H, Damgaard K, Szücs G, Zea Mendoza A, de la Puente Buijdos C, Sifuentes Giraldo WA, Midtvedt Ø, Garen T, Launay D, Valesini G, Riccieri V, Ionescu RM, Opris D, Groseanu L, Wigley FM, Mihai CM, Cornateanu RS, Ionitescu R, Gherghe AM, Gorga M, Dobrota R, Bojinca M, Schett G, Distler JH, Meroni P, Zeni S, Mouthon L, Keyser FD, Smith V, Cantatore FP, Corrado A, Ullman S, Iversen L, Pozzi MR, Eyerich K, Hein R, Knott E, Szechinski J, Wiland P, Szmyrka-Kaczmarek M, Sokolik R, Morgiel E, Krummel-Lorenz B, Saar P, Aringer M, Günther C, Anic B, Baresic M, Mayer M, Radominski SC, Müller Cde S, Azevedo VF, Agachi S, Groppa L, Chiaburu L, Russu E, Zenone T, Stebbings S, Highton J, Stamp L, Chapman P, Baron M, O'Donnell J, Solanki K, Doube A, Veale D, O'Rourke M, Loyo E, Rosato E, Pisarri S, Tanaseanu CM, Popescu M, Dumitrascu A, Tiglea I, Chirieac R, Ancuta C, Furst DE, Kafaja S, Lefebvre PG, Rubio SR, Exposito MV, Sibilia J, Chatelus E, Gottenberg JE, Chifflot H, Litinsky I, Venalis A, Butrimiene I, Venalis P, Rugiene R, Karpec D, Kerzberg E, Montoya F, Cosentino V: A gender gap in primary and secondary heart dysfunctions in systemic... Ann Rheum Dis. 2016;75(1): 163-9
  • Zerr P, Palumbo-Zerr K, Huang J, Tomcik M, Sumova B, Distler O, Schett G, Distler JH: Sirt1 regulates canonical TGF-? signalling to control fibroblast activation... Ann Rheum Dis. 2016;75(1): 226-33
 

Staff:

Chih-Wei Chen
Clara Dees
Jörg Distler
Alfyja Distler
Katja Dreißigacker
Jingang Huang
Rosbeth Kagwiria
Regina Kleinlein
Florian Layritz
Ruifang Liang
Neng-Yu Lin
Tatjana Mallano
Rossella Mancuso
Katrin Palumbo-Zerr
Monica Pascual
Amelie Schramm
Barbora Sumova
Svetlana Usherenko
Thomas Wohlfahrt
Pawel Zerr
Yun Zhang

 

 

 
 
 
 
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Summary