Junior Group Leader
|Dr. rer. nat. Bettina Grötsch|| |
Influence of immune regulation and inflammation on bone homeostasis
|Dr. rer. nat. Anika Grüneboom||Anika Grüneboom|
Dr. med. Dr. rer. nat. Luis Munoz
Neutrophil biology and immune regulation
Neutrophils are the most abundant immune cell type in the circulation; they migrate to injured tissues and can influence the subsequent immune responses. In systemic lupus erythematosus nuclear remnants are detoured by autoantibodies toward neutrophils exacerbating local and systemic inflammation. Under certain conditions neutrophils expel its own DNA decorated with granular proteins and modified histones in form of sticky neutrophil extracellular traps (NETs). These structures act as repositories for modified autoantigens and are endowed with intrinsic immunoregulatory mechanisms that offer opportunities for novel therapeutic interventions.
|Dr. rer. nat. Christine Schauer||Christine Schauer|