Head: Dr. rer. nat. Markus Hoffmann
During the course of a normal inflammation, a large number of immune cells die. Various forms of cell death exist, among them also highly coordinated processes that contribute to resolution of inflammation.
We investigate the impact that dying cells have on the development and maintenance of inflammatory diseases such as arthritis, Systemic Lupus Erythematosus (SLE), and gout. A special focus is laid on activation of the immune system by endogenous nucleic acids released from dying cells in combination with anti-microbial peptides, and on the influence of oxidation/reduction. The regulation of the bone metabolism is also addressed in our projects.