Matrix biology: Inflammatory pathways in arthritis and fibrosis

Medicine 3

Head of Department:
Prof. Dr. med. univ. Georg Schett

Modulation of chronic inflammation and tissue repair in arthritis and fibrosis

Head: Dr. med. Andreas Ramming

Physiologically the initiation and termination of inflammation is tightly controlled. Failure to appropriately stop inflammation, however, leads to chronic inflammation and pathologic tissue repair. So far, cure of chronic inflammatory diseases such as rheumatoid arthritis (RA) has not been achieved, as current anti-inflammatory therapies act by antagonizing the pro-inflammatory activating process only, and therefore have to be taken life-long. Therapies that control perpetuating tissue repair mechanisms that lead to fibrotic diseases such as systemic sclerosis, idiopathic pulmonary fibrosis (IPF), liver cirrhosis and chronic graft-versus-host disease (GvHD) are not yet available for clinical use. The socioeconomic burden of chronic inflammatory and fibrotic diseases is high, since they affect women and men early in life, entailing substantial indirect health care costs due to sick leave, permanent work disability and early retirement. Chronic inflammatory and fibrotic diseases account for at least one third of deaths worldwide and can affect virtually every organ system. The incidence of these diseases is continuously increasing over the last decades. Therefore, the development of new treatment strategies will become even more important in the future.

Selected publications of Dr. Andreas Ramming

 
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Dr. med. Andreas Ramming
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Staff:

Andreas Ramming
Simon Rauber
Gabriella Raimondo
Raminder Singh
Yuko Ariza
Alina Soare
Stefanie Weber
Charles Gwellem Anchang
Rahul Agarwal
Mina Saad
Kai-Ting Yang
Julia Friedrich
Madhavi Jane
Julia Koch
Lena Rupprich
Bettina Matalobos Lawaree
Nils Neise