Gout (urikopathy) is a metabolic disease in which uric acid accumulates in the body and is deposited in the form of tiny needle-tipped crystals in joints and tissue. The immune system tries to combat these crystals. Recent scientific studies have shown that certain immune cells (neutrophil granulocytes) burst when fighting gout crystals, with the cell contents forming dense networks around the critals. Thus, messenger substances of inflammation get caught and are deactivated there (published in Nature Medicine 2014 Apr 28).
A frequent cause is usually a genetic excretory disorder, so that it leads to an increased uric acid level in the blood. However, various triggers promote the outbreak of gout, including diseases (e.g. diabetes mellitus), medication, but also an unhealthy diet, lack of exercise and obesity.
About 80 percent of gout patients are men, mostly between the ages of 40 and 60, rarely in younger years. Women usually do not get gout before the onset of menopause.
The disease usually occurs suddenly with severe pain in a joint or in the whole finger or toe. The region is then red, swollen and hot.
In addition, general signs of inflammation such as fever, increased white blood cells (leukocytes) and an elevated uric acid level can occur. Interestingly, in mild cases, the attack of gout subsides after a few hours to 2 days. In more severe cases the acute condition can last up to 14 days, in advanced stages up to several weeks.
In case of seizure:
After the seizure, the goal is to lower the uric acid level in the blood serum using medication.
Today, gout is almost always curable under the condition that the patients adhere to the therapy and eat a balanced and low meat diet.