In 2015, the Federal Ministry of Education and Research (BMBF) approved the collaborative research project METARTHROS – Metabolic Impact on Joint and Bone Diseases within the research network Musculoskeletal Diseases. This nationwide, interdisciplinary consortium has the objective, to investigate the mechanisms underlying arthritis, diabetes and obesity.
Within eight sub-projects and one joint clinical trial, the molecular mechanisms of chronic inflammatory joint and bone diseases in correlation with metabolic diseases such as diabetes and obesity will be investigated.
This interdisciplinary consortium with leading participation of FAU scientists has the objective to investigate clinical relevant key factors and their functional characteristics in connection with inflammation and metabolism. Therefore, adipocytes, regulatory cells, nuclear receptors, soluble metabolic markers and signaling pathways will be analyzed. In order to develop new diagnostic tools, changes in bone structure, adipose tissue and inflammation will be determined by imaging techniques such as high-resolution computer tomography, quantitative computer tomography and magnetic resonance tomography. Through cooperation with the German Diabetes Center Düsseldorf, the impact of diabetes on joint and bone diseases can be comprehensively analyzed. This project, located at the Deutsches Rheuma-Forschungszentrum Berlin, evaluates different patient cohorts with diabetes and rheumatoid arthritis and analyzes epidemiological data in order to properly define the mutual influence of the diseases. The scientific findings will be validated in a clinical trial in order to benefit the patient as soon as possible.
Speaker: Prof. Dr. med. Georg Schett
Project Coordination: Sandra Jeleazcov