Medicine 3

Head of Department:
Prof. Dr. med. univ. Georg Schett

Priority Program SPP 1468 “Osteoimmunology - IMMUNOBONE – A Program to Unravel the Mutual Interactions between the Immune System and Bone”

An interdisciplinary cooperative project to investigate communication channels between the immune and skeletalsystem

Interactions between bone and immunsystem are important for development of diseases as osteoporosis or athrosis. The research project investigates how the activation of immune system have an influence on the skeletal system. Additionally, the consortium investgates the role of the bone as 'school' for the immune cells. The bone marrow is the so-called homestead of the hemopoietic system and so also of the immune cells. It is certainly conceivable that also the bone have an influence on the immune system.

Five of the in total 20 scientific project groups are located at the Department of Internal Medicine 3:

AG Schett The impact of ACPA on bone loss in patients with rheumatoid arthritis

AG Krönke Investigation of the role of the nuclear receptor NR4a1 during bone turnover and maintenance of the hematopoietic niche in the bone marrow

AG Distler Evaluation of the nuclear receptor Retinoid Acid Receptor related Receptor alpha (RORalpha) as a novel regulator of osteoclastogenesis in rheumatoid arthritis and osteoporosis

AG Herrmann / Hoffmann The role of oxidative burst in bone remodelling during chronic inflammation

AG Bozec / Mielenz How Fra/AP-1 transcription factors control bone niche

Speaker: Prof. Dr. med. Georg Schett

Project coordination: Sandra Jeleazcov


Further Information