Dr. rer. nat. Bettina Grötsch

selected publications

Team:
Verena Stallfort
Francoise Welfring
Stefan Hofmann

Osteoimmunology

Influence of immune regulation and inflammation on bone homeostasis
Our group is currently analyzing how changes in B cell differentiation and activation with B cell specific deletion of Fra1 or Fra2 affects bone homeostasis. Furthermore, we are studying the role of innate C type lectin receptors on inflammatory bone loss. The link between infections and inflammatory bone loss is incompletely understood. Our lab is analyzing the molecular mechanisms by which lectin receptors could link bacterial infections to bone loss. The results obtained from these studies will allow a better identification of the mechanisms regulating the interplay of the immune system and bone. This will provide a useful approach identifying new treatment strategies for osteoporosis and rheumatoid arthritis.

Dr. rer. nat. Anika Grüneboom

Team:
Daniela Weidner
Larysa Mokhir
Oliver Aust
 

Dr. med. Dr. rer. nat. Luis Munoz

selected publications

Team:
Malgorzata Podolska
Aparna Mahajan
Silke Winkler
Inas Shaban

Neutrophil biology and immune regulation

Neutrophils are the most abundant immune cell type in the circulation; they migrate to injured tissues and can influence the subsequent immune responses. In systemic lupus erythematosus nuclear remnants are detoured by autoantibodies toward neutrophils exacerbating local and systemic inflammation. Under certain conditions neutrophils expel its own DNA decorated with granular proteins and modified histones in form of sticky neutrophil extracellular traps (NETs). These structures act as repositories for modified autoantigens and are endowed with intrinsic immunoregulatory mechanisms that offer opportunities for novel therapeutic interventions.