Medizin 3

Digital Rheumatology and experimental Imaging

Head: PD Dr. med. Arnd Kleyer / Dr. med. David Simon

Epidemiological research with defined patient cohorts is an essential element to understand the outcome and course of rheumatic diseases and to provide optimal targeted treatment.

The group focuses on early rheumatoid arthritis, especially on the onset of RA. Anti-citrullinated autoantibodies (ACPA) can be detected years before typical symptoms such as swelling and stiffness of the joints occur. To understand the effects of autoimmunity on the human body and to optimize targeted treatment, we supervise patients in a cohort and examine those patients with most modern imaging procedures regarding bone changes and inflammatory changes. Therefore we use high-resolution peripheral quantitative computed tomography imaging (HR-pQCT) and 7-Tesla-magnetic resonance tomography imaging (7-Tesla-MRI) in cooperation with the Institute of Radiology. Besides patients with rheumatoid arthritis we accompany and examine patients with psoriasis and musculoskeletal complaints.

Innovative training concepts such as 3D-printing and virtual reality applications for students, physicians and patients complete the visual and epidemiological focus of our group.

Selected publications of Dr. med. Arnd Kleyer and Dr. med. David Simon

Ellmann H, Bayat S, Araujo E, Manger B, Kleyer A, Cavallaro A, Lell M, Schenker H, Simon D, Tascilar K, Baraf HSB, Schett G, Rech J: (2020) Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits Arthritis Rheumatol. 2020;72(1): 150-156
Pachowsky ML, Kleyer A, Wagner L, Langenbach A, Simon D, Janka R, May M, Welsch GH: (2020) Quantitative T2 Mapping Shows Increased Degeneration in Adjacent Intervertebral Discs Following Kyphoplasty. Cartilage. 2020;11(2): 152-159
Steffen U, Koeleman CA, Sokolova MV, Bang H, Kleyer A, Rech J, Unterweger H, Schicht M, Garreis F, Hahn J, Andes FT, Hartmann F, Hahn M, Mahajan A, Paulsen F, Hoffmann M, Lochnit G, Munoz LE, Wuhrer M, Falck D, Herrmann M, Schett G: (2020) IgA subclasses have different effector functions associated with distinct glycosylation profiles. Nat Commun. 2020;11(1):
Baraliakos X, Kleyer A, Simon D, Koehm M, Ohrndorf S, Sewerin P: (2020) [Imaging of psoriatic arthritis and aspects of radiographic progression]. Z Rheumatol. 2020;79(1): 40-52
Simon D, Berlin A, Tascilar K, Bayat S, Engelke K, Rech J, Figuereido C, Hueber A, Schett G, Kleyer A: (2019) THE PHYSIOLOGICAL FINGER JOINT ARCHITECTURE - AGE-RELATED INCREASE OF EROSIONS AND OSTEOPHYTES IN THE JOINTS OF HEALTHY INDIVIDUALS Ann Rheum Dis. 2019;78(): 602-603
Liphardt AM, Liehr S, Manger E, Bieniek L, Kleyer A, Simon D, Tascilar K, Sticherling M, Rech J, Schett G, Hueber A: (2019) HAND FUNCTION IS IMPAIRED IN PATIENTS WITH RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS, AND PSORIASIS COMPARED TO HEALTHY CONTROLS Ann Rheum Dis. 2019;78(): 2126-2126
Berlin A, Simon D, Tascilar K, Figueiredo C, Bayat S, Finzel S, Klaus E, Rech J, Hueber AJ, Kleyer A, Schett G: (2019) The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals. Osteoarthritis Cartilage. 2019;27(7): 1043-1047
Simon D, Tascilar K, Unbehend S, Bayat S, Meinderink T, Berlin A, Rech J, Hueber A, Schett G, Kleyer A: (2019) IMPACT OF PRIMARY HAND OSTEOARTHRITIS ON MICROSTRUCTURE AND BIOMECHANICS IN FINGER JOINTS Ann Rheum Dis. 2019;78(): 1868-1868
Kleyer A, Simon D, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Kroenke G, Schett G: (2019) MICRO-STRUCTURAL CHANGES ASSOCIATED WITH ANTI-CITRULLINATED VIMENTIN AUTOIMMUNITY IN RA-AT-RISK INDIVIDUALS PRECIPITATE THE ONSET OF RHEUMATOID ARTHRITIS Ann Rheum Dis. 2019;78(): 133-133
Culemann S, Grueneboom A, Angel Nicolas-Avila JA, Weidner D, Laemmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Baeuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Kroenke G: (2019) Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572(7771): 670-675

Contact

PD Dr. med. Arnd Kleyer: business card
Dr. med. David Simon: business card

Staff:

Arnd Kleyer
David Simon
Larissa Valor-Mendez
Johannes Knitza
Sara Bayat
Fabian Hartmann
Anna-Maria Liphardt
Louis Schuster
Timo Meinderink
Ulrike Müller

Medicine 3

Digital Rheumatology and experimental Imaging

Selected publications of Dr. med. Arnd Kleyer and Dr. med. David Simon