Head: Dr. rer. nat. Bettina Grötsch
Our group is currently investigating how changes in early and late B-cell development and activation with B-cell specific deletion of Fra1 or Fra2 influence bone homeostasis. Furthermore, we are investigating the influence of C-type lectin receptors on inflammation-induced bone loss. The exact link between infections and inflammatory bone loss has not yet been fully elucidated. We are analysing the molecular mechanisms by which C-type lectin receptors are responsible for linking bacterial infections to infection-related bone loss. The results from our studies provide a better understanding of the complex interplay between the immune system and bone. Our data will provide a good approach to uncover new markers and treatment strategies in rheumatoid arthritis.