Prof. Dr. A. Bozec

Publications: Prof. Dr. rer. nat. A. Bozec

Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A: (2024) Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Nat Commun. 2024;15(1):
Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A: (2024) L-arginine metabolism inhibits arthritis and inflammatory bone loss. Ann Rheum Dis. 2024;83(1): 72-87
Taubmann J, Müller F, Yalcin Mutlu M, Völkl S, Aigner M, Bozec A, Mackensen A, Grieshaber-Bouyer R, Schett G: (2024) CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2024;76(4): 497-504
Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D: (2023) Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass. J Bone Miner Res. 2023;38(1): 86-102
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R: (2023) Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 2023;15(2):
Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A: (2023) High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production. Cell Rep. 2023;42(7):
Sommer J, Ehnis H, Seitz T, Schneider J, Wild AB, Moceri S, Buechler C, Bozec A, Weber GF, Merkel S, Beckervordersandforth R, Steinkasserer A, Schüle R, Trebicka J, Hartmann A, Bosserhoff A, von Hörsten S, Dietrich P, Hellerbrand C: (2023) Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. Int J Mol Sci. 2023;24(19):
Deschner J, Schröder A, Weber M, Galler K, Proff P, Kirschneck C, Bozec A, Jantsch J: (2023) Advancing oral immunology for improving oral health. J Orofac Orthop. 2023;():
Luo Y, Tong Y, Wu L, Niu H, Li Y, Su LC, Wu Y, Bozec A, Zaiss MM, Qing P, Zhao H, Tan C, Zhang Q, Zhao Y, Tang H, Liu Y: (2023) Alteration of Gut Microbiota in Individuals at High-Risk for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance. Arthritis Rheumatol. 2023;75(10): 1736-1748
Almenara-Fuentes L, Rodriguez-Fernandez S, Rosell-Mases E, Kachler K, You A, Salvado M, Andreev D, Steffen U, Bang H, Bozec A, Schett G, Le Panse R, Verdaguer J, Dalmases M, Rodriguez-Vidal S, Barneda-Zahonero B, Vives-Pi M: (2023) A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens. Nanomedicine. 2023;48():
Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Sembritzki NK, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Lenz B, Schumann G, Kornhuber J, Müller CP: (2023) Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males. Cereb Cortex. 2023;33(3): 844-864
Kadur Lakshminarasimha Murthy P, Xi R, Arguijo D, Everitt JI, Kocak DD, Kobayashi Y, Bozec A, Vicent S, Ding S, Crawford GE, Hsu D, Tata PR, Reddy T, Shen X: (2022) Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity. Dev Cell. 2022;57(3): 310-328.e9
Urbanczyk S, Baris OR, Hofmann J, Taudte RV, Guegen N, Golombek F, Castiglione K, Meng X, Bozec A, Thomas J, Weckwerth L, Mougiakakos D, Schulz SR, Schuh W, Schlötzer-Schrehardt U, Steinmetz TD, Brodesser S, Wiesner RJ, Mielenz D: (2022) Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle. Cell Rep. 2022;39(10):
Marino S, Hannemann N, Bishop RT, Zeng F, Carrasco G, Meurisse S, Li B, Sophocleous A, Sparatore A, Baeuerle T, Vukicevic S, Auberval M, Mollat P, Bozec A, Idris AI: (2022) Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis. Biochem Pharmacol. 2022;195():
Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A: (2022) Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis. Ann Rheum Dis. 2022;81(8): 1119-1130
Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E, Mühl-Zürbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bäuerle T, Nagel L, Schett G, Bozec A, Steinkasserer A: (2022) The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. Front Immunol. 2022;13():
Andreev D, Kachler K, Schett G, Bozec A: (2022) Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism. Bone. 2022;162():
Meng X, Lin Z, Cao S, Janowska I, Sonomoto K, Andreev D, Katharina K, Wen J, Knaup KX, Wiesener MS, Krönke G, Rizzi M, Schett G, Bozec A: (2022) Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res. 2022;10(1):
Groetsch B, Schachtschabel E, Tripal P, Schmid B, Smith AS, Schett G, Bozec A: (2022) Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts. Front Immunol. 2022;13():
Gregoric G, Gaculenko A, Nagel L, Popp V, Maschauer S, Prante O, Saake M, Schett G, Uder M, Ellmann S, Bozec A, Bäuerle T: (2022) Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT. Cancers (Basel). 2022;14(10):
Li Y, Cao S, Gaculenko A, Zhan Y, Bozec A, Chen X: (2022) Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis. Front Endocrinol (Lausanne). 2022;13():
Zhang W, Lyu P, Andreev D, Jia Y, Zhang F, Bozec A: (2022) Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma. Front Cell Dev Biol. 2022;10():
Qin Y, Cai ML, Jin HZ, Huang W, Zhu C, Bozec A, Huang J, Chen Z: (2022) Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways. Ann Rheum Dis. 2022;81(11): 1504-1514
Dölling M, Eckstein M, Singh J, Schauer C, Schoen J, Shan X, Bozec A, Knopf J, Schett G, Muñoz LE, Herrmann M: (2022) Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction. Front Immunol. 2022;13():
Vielreicher M, Bozec A, Schett G, Friedrich O: (2021) Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging. Front Bioeng Biotechnol. 2021;9():
Gaculenko A, Gregoric G, Popp V, Seyler L, Ringer M, Kachler K, Wu Z, Kisel W, Hofbauer C, Hofbauer LC, Uder M, Schett G, Bäuerle T, Bozec A: (2021) Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents. J Bone Miner Res. 2021;36(12): 2440-2452
Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A: (2021) The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model. Front Immunol. 2021;12():
Bergmann C, Hallenberger L, Chenguiti Fakhouri S, Merlevede B, Brandt A, Dees C, Zhu H, Zehender A, Zhou X, Schwab A, Chen CW, Györfi AH, Matei AE, Chakraborty D, Trinh-Minh T, Rauber S, Coras R, Bozec A, Kreuter A, Ziemer M, Schett G, Distler JHW: (2021) X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc). Ann Rheum Dis. 2021;80(8): 1048-1056
Degboé Y, Sunzini F, Sood S, Bozec A, Sokolova MV, Zekovic A, McInnes IB, Schett G, Goodyear CS: (2021) Apremilast inhibits inflammatory osteoclastogenesis. Rheumatology (Oxford). 2021;61(1): 452-461
Hülser ML, Luo Y, Frommer K, Hasseli R, Köhler K, Diller M, Van Nie L, Rummel C, Roderfeld M, Roeb E, Schett G, Bozec A, Müller-Ladner U, Neumann E: (2021) Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model. Sci Rep. 2021;11(1):
Hofbauer LC, Bozec A, Rauner M, Jakob F, Perner S, Pantel K: (2021) Novel approaches to target the microenvironment of bone metastasis. Nat Rev Clin Oncol. 2021;18(8): 488-505
Meng X, Wielockx B, Rauner M, Bozec A: (2021) Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease. Front Cell Dev Biol. 2021;9():
Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP: (2021) Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. Mol Psychiatry. 2021;26(12): 7403-7416
Weber M, Wehrhan F, Deschner J, Sander J, Ries J, Möst T, Bozec A, Gölz L, Kesting M, Lutz R: (2021) The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases. Int J Mol Sci. 2021;22(3):
Chen GL, Li R, Chen XX, Wang J, Cao S, Song R, Zhao MC, Li LM, Hannemmann N, Schett G, Qian C, Bozec A: (2021) Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. Cell Death Differ. 2021;28(4): 1364-1378
Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A: (2021) Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis. Ann Rheum Dis. 2021;80(4): 451-468
Heinen H, Seyler L, Popp V, Hellwig K, Bozec A, Uder M, Ellmann S, Bäuerle T: (2021) Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis. Bone. 2021;144():
Lin Z, Meng X, Wen J, Corral JM, Andreev D, Kachler K, Schett G, Chen X, Bozec A: (2020) Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients. Front Oncol. 2020;10():
Andreev D, Liu M, Weidner D, Kachler K, Faas M, Grüneboom A, Schlötzer-Schrehardt U, Muñoz LE, Steffen U, Grötsch B, Killy B, Krönke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A: (2020) Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest. 2020;130(9): 4811-4830
Sauermilch HM, Hulser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2020) COMPARISON OF INFLAMMATION DURING METABOLIC CHANGES IN RHEUMATOID AND OSTEOARTHRITIS MOUSE MODELS Ann Rheum Dis. 2020;79 Suppl 1(): 242-243
Liu M, Andreev D, Kachler K, Koelle J, Rauber S, Ramming A, Finotto S, Schett G, Bozec A: (2020) ALLERGIC ASTHMA INDUCES THE ACCUMULATION OF SYNOVIAL RESIDENT EOSINOPHILS, TRIGGERING THE RESOLUTION OF INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2020;79 Suppl 1(): 86-86
Cao S, Chen X, Schett G, Bozec A: (2020) L-ARGININE SUPPLEMENTATION AMELIORATES BONE EROSION IN RHEUMATOID ARTHRITIS THROUGH INHIBITION OF RANKL/RANK/TRAF6 PATHWAY AND REPROGRAMMING OSTEOCLAST METABOLISM Ann Rheum Dis. 2020;79 Suppl 1(): 927-927
Seidel CL, Gerlach RG, Wiedemann P, Weider M, Rodrian G, Hader M, Frey B, Gaipl US, Bozec A, Cieplik F, Kirschneck C, Bogdan C, Gölz L: (2020) Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile. Int J Mol Sci. 2020;21(21):
Ellmann S, Seyler L, Gillmann C, Popp V, Treutlein C, Bozec A, Uder M, Bäuerle T: (2020) Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model. J Vis Exp. 2020;(162):
Weider M, Schröder A, Docheva D, Rodrian G, Enderle I, Seidel CL, Andreev D, Wegner M, Bozec A, Deschner J, Kirschneck C, Proff P, Gölz L: (2020) A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress. Int J Mol Sci. 2020;21(21):
Liphardt AM, Windahl SH, Sehic E, Hannemann N, Gustafsson KL, Bozec A, Schett G, Engdahl C: (2020) Changes in mechanical loading affect arthritis-induced bone loss in mice Bone. 2020;131():
Schaeffer A, Czlonka E, Tirado-Gonzalez I, Bose T, Beauvarlet J, Kur I, Bozec A, Bonig H, Brandts CH, Platzbecker U, Gotze KS, Medyouf H: (2020) Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS Blood. 2020;136 Suppl 1():
Chen Z, Bozec A, Ramming A, Schett G: (2019) Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat Rev Rheumatol. 2019;15(1): 9-17
Hahn J, Schauer C, Czegley C, Kling L, Petru L, Schmid B, Weidner D, Reinwald C, Biermann MHC, Blunder S, Ernst J, Lesner A, Bäuerle T, Palmisano R, Christiansen S, Herrmann M, Bozec A, Gruber R, Schett G, Hoffmann MH: (2019) Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases. FASEB J. 2019;33(1): 1401-1414
Zaiss MM, Hall C, McGowan NWA, Babb R, Devlia V, Lucas S, Meghji S, Henderson B, Bozec A, Schett G, David JP, Panayi GS, Grigoriadis AE, Corrigall VM: (2019) Binding Immunoglobulin Protein (BIP) Inhibits TNF-α-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model. ACR Open Rheumatol. 2019;1(6): 382-393
Grötsch B, Lux A, Rombouts Y, Hoffmann AC, Andreev D, Nimmerjahn F, Xiang W, Scherer HU, Schett G, Bozec A: (2019) Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss. J Bone Miner Res. 2019;34(7): 1352-1365
Grötsch B, Bozec A, Schett G: (2019) In Vivo Models of Rheumatoid Arthritis. Methods Mol Biol. 2019;1914(): 269-280
Royzman D, Andreev D, Stich L, Rauh M, Bäuerle T, Ellmann S, Boon L, Kindermann M, Peckert K, Bozec A, Schett G, Steinkasserer A, Zinser E: (2019) Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner. Front Immunol. 2019;10():
Ellmann S, Seyler L, Evers J, Heinen H, Bozec A, Prante O, Kuwert T, Uder M, Bäuerle T: (2019) Prediction of early metastatic disease in experimental breast cancer bone metastasis by combining PET/CT and MRI parameters to a Model-Averaged Neural Network. Bone. 2019;120(): 254-261
Schröder A, Neubert P, Titze J, Bozec A, Neuhofer W, Proff P, Kirschneck C, Jantsch J: (2019) Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. JCI Insight. 2019;4(23):
Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Canete JD, Chen XX, Baeuerle T, Vera J, Bogdan C, Schett G, Bozec A: (2019) Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. J Clin Invest. 2019;129(7): 2669-2684
Sauermilch HM, Huelser ML, Schreiyaeck C, Luo YB, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2019) Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse Models Arthritis Rheumatol. 2019;71():
Sauermilch HM, Huelser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2019) EFFECT OF HIGH FAT DIET ON SYSTEMIC AND LOCAL INFLAMMATION IN THE CONTEXT OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS MOUSE MODELS Ann Rheum Dis. 2019;78(): A72-A72
Steffen U, Schett G, Bozec A: (2019) How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis Front Immunol. 2019;10():
Sauermilch HM, Huelser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2019) Obesity as an Influence Parameter of rheumatoid Arthritis and Osteoarthritis (Arthrosis) in the Mouse Model Internist (Berl). 2019;60(): S39-S39
Hannemann N, Cao S, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Uebe S, Ekici A, Rech J, Baeuerle T, Bogdan C, Vera J, Schett G, Bozec A: (2019) INHIBITION OF ARGINASE-1 EXPRESSION BY THE TRANSCRIPTION FACTOR FRA-1 IN MACROPHAGES EXACERBATES RHEUMATOID ARTHRITIS INFLAMMATION Ann Rheum Dis. 2019;78(): A27-A27
Bozec A, Luo Y, Engdahl C, Figueiredo C, Bang H, Schett G: (2018) Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner. Arthritis Res Ther. 2018;20(1):
Schett G, Bozec A, Bekeredjian-Ding I, Chang HD, David JP, Dörner T, Grässel S, Gunzer M, Manz R, Mei H, Mielenz D, Müller-Ladner U, Neumann E, Radbruch A, Richter W, Straub RH: (2018) [New insights into the function of bone marrow]. Z Rheumatol. 2018;77(Suppl 1): 4-7
Huelser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Neumann E, Mueller-Ladner U: (2018) ADIPOCYTOKINES LINKING OBESITY AND OSTEOARTHRITIS Ann Rheum Dis. 2018;77(): A49-A50
Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM: (2018) Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24(1): 169-180
Huelser ML, Schreiyaeck C, Luo YB, Bozec A, Schett G, Neumann E, Mueller-Ladner U: (2018) Adipokine in the Arthritis Mouse Model Internist (Berl). 2018;59(): S35-S35
Luo Y, Grötsch B, Hannemann N, Jimenez M, Ipseiz N, Uluçkan Ö, Lin N, Schett G, Wagner EF, Bozec A: (2018) Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin. Mol Cell Biol. 2018;38(22):
Huelser ML, Sauermilch HM, Schreiyaeck C, Luo YB, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2018) Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models Arthritis Rheumatol. 2018;70():
Bergmann C, Merlevede B, Beyer C, Hallenberger L, Brandt A, Dees C, Poetter S, Bozec A, Schett G, Distler J: (2018) THE AP1 TRANSCRIPTION FACTOR CJUN AMPLIFIES HEDGEHOG-INDUCED FIBROBLAST ACTIVATION AND TISSUE FIBROSIS Ann Rheum Dis. 2018;77(): 732-733
Huelser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2018) DIET INDUCED METABOLIC CHANGES IN AN OSTEOARTHRITIS MOUSE MODEL Ann Rheum Dis. 2018;77(): 104-104
Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A: (2018) Hypoxia-inducible factor-1? is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun. 2018;9(1): 251
Bergmann C, Brandt A, Merlevede B, Hallenberger L, Dees C, Wohlfahrt T, Pötter S, Zhang Y, Chen CW, Mallano T, Liang R, Kagwiria R, Kreuter A, Pantelaki I, Bozec A, Abraham D, Rieker R, Ramming A, Distler O, Schett G, Distler JHW: (2018) The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis. Ann Rheum Dis. 2018;77(1): 150-158
Bozec A, Soulat D: (2017) Latest perspectives on macrophages in bone homeostasis. Pflugers Arch. 2017;469(3-4): 517-525
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S: (2017) An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8(): 14294
Hannemann N, Jordan J, Paul S, Reid S, Baenkler HW, Sonnewald S, Bäuerle T, Vera J, Schett G, Bozec A: (2017) The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages. J Immunol. 2017;198(9): 3605-3614
Bozec A, Zaiss MM: (2017) T Regulatory Cells in Bone Remodelling. Curr Osteoporos Rep. 2017;15(3): 121-125
Ubieta K, Garcia M, Grötsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D, Bozec A: (2017) Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription. J Exp Med. 2017;214(7): 2059-2071
Stein M, Dütting S, Mougiakakos D, Bösl M, Fritsch K, Reimer D, Urbanczyk S, Steinmetz T, Schuh W, Bozec A, Winkler TH, Jäck HM, Mielenz D: (2017) A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1. Cell Death Differ. 2017;24(7): 1239-1252
Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A: (2017) Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017;23(8): 938-944
Simon D, Derer A, Andes FT, Lezuo P, Bozec A, Schett G, Herrmann M, Harre U: (2017) Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone. 2017;105(): 35-41
Urbanczyk S, Stein M, Dütting S, Mougiakakos D, Bösl M, Reimer D, Steinmetz T, Schuh W, Bozec A, Winkler T, Jäck HM, Mielenz D: (2017) Influence of Swiprosin2/EFhd1 on the metabolic control of B cell differentiation and humoral immunity Eur J Immunol. 2017;47 2(): 96-96
Hulser ML, Schreiyack C, Luo YB, Bozec A, Schett G, MullerLadner U, Neumann E: (2017) ADIPOKINES AS LINK BETWEEN ARTHRITIS AND METABOLISM Ann Rheum Dis. 2017;76 1(): A29-A30
Omata Y, Lucas S, Garcia M, Wirtz S, Bozec A, Schett G, Zaiss MM: (2017) REGULATION OF ARTHRITIS BY TYPE 2 INNATE LYMPHOID CELLS Ann Rheum Dis. 2017;76 1(): A3-A3
Hannemann N, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Hueber A, Reid S, Sonnewald S, Bauerle T, Vera J, Bogdan C, Schett G, Bozec A: (2017) FRA-1 TRANSCRIPTION FACTOR EXPRESSION IN MACROPHAGES FOSTER INFLAMMATION DURING RHEUMATOID ARTHRITIS DEVELOPMENT Ann Rheum Dis. 2017;76 1(): A6-A6
Bergmann C, Brandt A, Dees C, Zhang Y, Chen CW, Mallano T, Wohlfahrt T, Liang RF, Kagwiria R, Bozec A, Rieker R, Abraham D, Ramming A, Distler O, Schett G, Distler J: (2017) The Histone Demethylase Jumonji Domain-Containing Protein 3 (JMJD3) As Central Mediator of Fibroblast Activation Arthritis Rheumatol. 2017;69():
Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Bozec A, Herrmann M, Zaiss M, Fearon U, Veale DJ, Canete J, Distler O, Rivellese F, Pitzalis C, Schett G, Distler J, Ramming A: (2017) IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis Arthritis Rheumatol. 2017;69():
Huelser ML, Schreiyaeck C, Luo YB, Bozec A, Schett G, Neumann E, Mueller-Ladner U: (2017) Adipocytokines in an Osteoarthritis Mouse Model Arthritis Rheumatol. 2017;69():
Andreev D, Chen Z, Oeser K, Krljanac B, Hueber A, Kleyer A, Weigmann B, Voehringer D, Schett G, Bozec A: (2017) Th2 and eosinophil responses ameliorate arthritis and inflammatory bone loss Eur J Immunol. 2017;47(): 132-132
Hannemann N, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Uebe S, Ekici A, Reid S, Sonnewald S, Baeuerle T, Bogdan C, Vera J, Schett G, Bozec A: (2017) Inhibited Arginase-1 Expression by Fra-1 in Myeloid Cells Enhance Rheumatoid Arthritis Inflammation Eur J Immunol. 2017;47(): 252-252
Bozec A, Luo Y, Engdahl C, Figueiredo C, Bang H, Schett G: (2017) ABATACEPT BUT NOT TNF INHIBITORS BLOCK AUTOANTIBODY-MEDIATED CYTOKINE PRODUCTION BY MONOCYTES Ann Rheum Dis. 2017;76(): 848-849
Bergmann C, Brandt A, Dees C, Wohlfahrt T, Zhang Y, Chen CW, Mallano T, Liang R, Kagwiria R, Kam PS, Bozec A, Abraham D, Rieker R, Ramming A, Distler O, Schett G, Distler J: (2017) EPIGENETIC REGULATION OF FRA2 BY JMJD3 REGULATES FIBROBLAST ACTIVATION IN SYSTEMIC SCLEROSIS Ann Rheum Dis. 2017;76(): 892-893
Huelser ML, Schreiyaeck C, Luo YB, Bozec A, Schett G, Mueller-Ladner U, Neumann E: (2017) Adipocytokine as a Link between Metabolism and Osteoarthritis Internist (Berl). 2017;58(): S11-S12
Huelser ML, Schreiyack C, Luo Y, Bozec A, Schett G, Neumann E, Mueller-Ladner U: (2017) METABOLISM AND OSTEOARTHRITIS ARE LINKED BY ADIPOKINES Ann Rheum Dis. 2017;76(): 1063-1063
Weekes D, Kashima TG, Zandueta C, Perurena N, Thomas DP, Sunters A, Vuillier C, Bozec A, El-Emir E, Miletich I, Patiño-Garcia A, Lecanda F, Grigoriadis AE: (2016) Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1. Oncogene. 2016;35(22): 2852-61
Chen GL, Luo Y, Eriksson D, Meng X, Qian C, Bäuerle T, Chen XX, Schett G, Bozec A: (2016) High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6. Oncotarget. 2016;7(18): 26653-69
Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A: (2016) Th2 and eosinophil responses suppress inflammatory arthritis. Nat Commun. 2016;7(): 11596
Bozec A, Hannemann N: (2016) Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis. J Vis Exp. 2016;(112):
Weekes D, Kashima TG, Zandueta C, Perurena N, Thomas DP, Sunters A, Vuillier C, Bozec A, El-Emir E, Miletich I, Patiño-Garcia A, Lecanda F, Grigoriadis AE: (2016) Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1. Oncogene. 2016;35(22): 2948
Schwabe K, Garcia M, Ubieta K, Hannemann N, Herbort B, Luther J, Noël D, Jorgensen C, Casteilla L, David JP, Stock M, Herrmann M, Schett G, Bozec A: (2016) Inhibition of Osteoarthritis by Adipose-Derived Stromal Cells Overexpressing Fra-1 in Mice. Arthritis Rheumatol. 2016;68(1): 138-51
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Gwinn D, Sayles LC, Chuang CH, Andersen JB, Bozec A, Sweet-Cordero A, Sage J, Lecanda F, Vicent S: (2016) An integrative cross-tumors approach identifies FOSL1 as an oncogene dependency in KRAS-driven lung cancer J Thorac Oncol. 2016;11 Suppl S(2): S51-S51

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Publications: Prof. Dr. rer. nat. A. Bozec

Emergency

Emergencies UKER

Patients & Visitors

Doctors & referring physicians

Research

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