Modulation of chronic inflammation and tissue repair in arthritis and fibrosis
Head: Prof. Dr. med. Andreas Ramming
Physiologically the initiation and termination of inflammation is tightly controlled. Failure to appropriately stop inflammation, however, leads to chronic inflammation and pathologic tissue repair. So far, cure of chronic inflammatory diseases such as rheumatoid arthritis (RA) has not been achieved, as current anti-inflammatory therapies act by antagonizing the pro-inflammatory activating process only, and therefore have to be taken life-long. Therapies that control perpetuating tissue repair mechanisms that lead to fibrotic diseases such as systemic sclerosis, idiopathic pulmonary fibrosis (IPF), liver cirrhosis and chronic graft-versus-host disease (GvHD) are not yet available for clinical use. The socioeconomic burden of chronic inflammatory and fibrotic diseases is high, since they affect women and men early in life, entailing substantial indirect health care costs due to sick leave, permanent work disability and early retirement. Chronic inflammatory and fibrotic diseases account for at least one third of deaths worldwide and can affect virtually every organ system. The incidence of these diseases is continuously increasing over the last decades. Therefore, the development of new treatment strategies will become even more important in the future.
Please follow us on twitter
Selected publications of Prof. Dr. Andreas Ramming
- (2023) Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography. Rheumatology (Oxford). 2023;62(2): 841-849
- (2023) Diagnostic delay stages and pre-diagnostic treatment in patients with suspected rheumatic diseases before special care consultation: results of a multicenter-based study. Rheumatol Int. 2023;43(3): 495-502
- (2023) Student-led clinics and ePROs to accelerate diagnosis and treatment of patients with axial spondyloarthritis: results from a prospective pilot study. Rheumatol Int. 2023;43(10): 1905-1911
- (2023) Anti-acid therapy in SSc-associated interstitial lung disease: long-term outcomes from the German Network for Systemic Sclerosis. Rheumatology (Oxford). 2023;62(9): 3067-3074
- (2022) Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort. Arthritis Rheumatol. 2022;74(5): 783-790
- (2022) Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease. Ann Rheum Dis. 2022;81(10): 1400-8
- (2022) Number of necessary training examples for Neural Networks with different number of trainable parameters. J Pathol Inform. 2022;13():
- (2022) Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease. Ann Rheum Dis. 2022;81(7): 1023-1027
- (2022) Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy. Rheumatology (Oxford). 2022;61(7): 2999-3009
- (2022) Microstructural Bone Changes Are Associated With Broad-Spectrum Autoimmunity and Predict the Onset of Rheumatoid Arthritis. Arthritis Rheumatol. 2022;74(3): 418-426