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Prof. Dr. J. Distler

Publications: Prof. Dr. med. J. Distler

  • Fuchs F, Morf H, Mohn J, Mühlensiepen F, Ignatyev Y, Bohr D, Araujo E, Bergmann C, Simon D, Kleyer A, Vorbrüggen W, Ramming A, Distler JHW, Bartz-Bazzanella P, Schett G, Welcker M, Hueber AJ, Knitza J: Diagnostic delay stages and pre-diagnostic treatment in patients with suspected rheumatic diseases before special care consultation: results of a multicenter-based study. Rheumatol Int. 2023;43(3): 495-502
  • Treutlein C, Distler JHW, Tascilar K, Fakhouri SC, Györfi AH, Atzinger A, Matei AE, Dees C, Büttner-Herold M, Kuwert T, Prante O, Bäuerle T, Uder M, Schett G, Schmidkonz C, Bergmann C: Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT. Eur J Nucl Med Mol Imaging. 2023;50(6): 1629-1635
  • Györfi AH, Schett G, Distler JHW: Response to: 'Correspondence on 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis'' by Jeny et al. Ann Rheum Dis. 2022;81(12):
  • Maher TM, Bourdin A, Volkmann ER, Vettori S, Distler JHW, Alves M, Stock C, Distler O: Decline in forced vital capacity in subjects with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial compared with healthy reference subjects. Respir Res. 2022;23(1):
  • Riemekasten G, Distler JHW: A broad look into the future of systemic sclerosis. Ther Adv Musculoskelet Dis. 2022;14():
  • Liang M, Matteson EL, Abril A, Distler JHW: The role of antifibrotics in the treatment of rheumatoid arthritis-associated interstitial lung disease. Ther Adv Musculoskelet Dis. 2022;14():
  • Hughes M, Heal C, Henes J, Balbir-Gurman A, Distler JHW, Airò P, Müller-Ladner U, Hunzelmann N, Kerzberg E, Rudnicka L, Truchetet ME, Stebbings S, Tanaka Y, Hoffman-Vold AM, Gabrielli A, Distler O, Matucci-Cerinic M, EUSTAR Collaborators: Digital pitting scars are associated with a severe disease course and death in systemic sclerosis: a study from the EUSTAR cohort. Rheumatology (Oxford). 2022;61(3): 1141-1147
  • Matei AE, Kubánková M, Xu L, Györfi AH, Boxberger E, Soteriou D, Papava M, Prater J, Hong X, Bergmann C, Kräter M, Schett G, Guck J, Distler JHW: Biophysical phenotyping of circulating immune cells identifies a distinct monocyte-driven signature in systemic sclerosis. Arthritis Rheumatol. 2022;():
  • Li YN, Chen CW, Trinh-Minh T, Zhu H, Matei AE, Györfi AH, Kuwert F, Hubel P, Ding X, Manh CT, Xu X, Liebel C, Fedorchenko V, Liang R, Huang K, Pfannstiel J, Huang MC, Lin NY, Ramming A, Schett G, Distler JHW: Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153. Bone Res. 2022;10(1):
  • Shi X, Chen Y, Liu Q, Mei X, Liu J, Tang Y, Luo R, Sun D, Ma Y, Wu W, Tu W, Zhao Y, Xu W, Ke Y, Jiang S, Huang Y, Zhang R, Wang L, Chen Y, Xia J, Pu W, Zhu H, Zuo X, Li Y, Xu J, Gao F, Wei D, Chen J, Yin W, Wang Q, Dai H, Yang L, Guo G, Cui J, Song N, Zou H, Zhao S, Distler JHW, Jin L, Wang J: LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clin Transl Med. 2022;12(1):
  • Matteson EL, Kelly C, Distler JHW, Hoffmann-Vold AM, Seibold JR, Mittoo S, Dellaripa PF, Aringer M, Pope J, Distler O, James A, Schlenker-Herceg R, Stowasser S, Quaresma M, Flaherty KR, INBUILD Trial Investigators: Nintedanib in Patients With Autoimmune Disease-Related Progressive Fibrosing Interstitial Lung Diseases: Subgroup Analysis of the INBUILD Trial. Arthritis Rheumatol. 2022;74(6): 1039-1047
  • Blank N, Schmalzing M, Moinzadeh P, Oberste M, Siegert E, Müller-Ladner U, Riemekasten G, Günther C, Kötter I, Zeidler G, Pfeiffer C, Juche A, Jandova I, Ehrchen J, Susok L, Schmeiser T, Sunderkötter C, Distler JHW, Worm M, Kreuter A, Keyßer G, Lorenz HM, Krieg T, Hunzelmann N, Henes J, German Network for Systemic Sclerosis: Autologous hematopoietic stem cell transplantation improves long-term survival-data from a national registry. Arthritis Res Ther. 2022;24(1):
  • Distler JHW, O'Reilly S: Epigenetic profiling of twins identify repression of KLF4 as a novel pathomechanism in systemic sclerosis. Ann Rheum Dis. 2022;81(2): 151-152
  • Pu W, Zhang R, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JHW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J: Genetic Associations of Non-Major Histocompatibility Complex Susceptibility Loci with Systemic Sclerosis in a Han Chinese Population. J Invest Dermatol. 2022;142(7): 2039-2042.e7
  • Knitza J, Muehlensiepen F, Ignatyev Y, Fuchs F, Mohn J, Simon D, Kleyer A, Fagni F, Boeltz S, Morf H, Bergmann C, Labinsky H, Vorbrüggen W, Ramming A, Distler JHW, Bartz-Bazzanella P, Vuillerme N, Schett G, Welcker M, Hueber AJ: Patient's Perception of Digital Symptom Assessment Technologies in Rheumatology: Results From a Multicentre Study. Front Public Health. 2022;10():
  • Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, Penack O, Santomasso BD, Zeiser R, Angstwurm K, MacDonald KPA, Kimberly WT, Taylor N, Bilic E, Banas B, Buettner-Herold M, Sinha N, Greinix HT, Pidala J, Schultz KR, Williams KM, Inamoto Y, Cutler C, Griffith LM, Lee SJ, Sarantopoulos S, Pavletic SZ, Wolff D: Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. Transplant Cell Ther. 2022;28(8): 426-445
  • Kondo M, Suzuki T, Kawano Y, Kojima S, Miyashiro M, Matsumoto A, Kania G, Błyszczuk P, Ross RL, Mulipa P, Del Galdo F, Zhang Y, Distler JHW: Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis. Arthritis Res Ther. 2022;24(1):
  • Mauer J, Kuckhahn A, Ramsperger-Gleixner M, Ensminger SM, Distler JHW, Weyand M, Heim C: Nintedanib reduces alloimmune-induced chronic airway changes in murine tracheal allografts. Transpl Immunol. 2022;73():
  • Cavagna L, Meloni F, Meyer A, Sambataro G, Belliato M, De Langhe E, Cavazzana I, Pipitone N, Triantafyllias K, Mosca M, Barsotti S, Zampogna G, Biglia A, Emmi G, De Visser M, Van Der Kooi A, Parronchi P, Hirschi S, da Silva JAP, Scirè CA, Furini F, Giannini M, Martinez Gonzalez O, Damian L, Piette Y, Smith V, Mera-Valera A, Bachiller-Corral J, Cabezas Rodriguez I, Brandy-Garcia AM, Maurier F, Perrin J, Gonzalez-Moreno J, Drott U, Delbruck C, Schwarting A, Arrigoni E, Sebastiani GD, Iuliano A, Nannini C, Quartuccio L, Rodriguez Cambron AB, Blázquez Cañamero MÁ, Villa Blanco I, Cagnotto G, Pesci A, Luppi F, Dei G, Romero Bueno FI, Franceschini F, Chiapparoli I, Zanframundo G, Lettieri S, De Stefano L, Cutolo M, Mathieu A, Piga M, Prieto-González S, Moraes-Fontes MF, Fonseca JE, Jovani V, Riccieri V, Santaniello A, Montfort S, Bilocca D, Erre GL, Bartoloni E, Gerli R, Monti MC, Lorenz HM, Sambataro D, Bellando Randone S, Schneider U, Valenzuela C, Lopez-Mejias R, Cifrian J, Mejia M, Gonzalez Perez MI, Wendel S, Fornaro M, De Luca G, Orsolini G, Rossini M, Dieude P, Knitza J, Castañeda S, Voll RE, Rojas-Serrano J, Valentini A, Vancheri C, Matucci-Cerinic M, Feist E, Codullo V, Iannone F, Distler JH, Montecucco C, Gonzalez-Gay MA, AENEAS collaborative group: Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies. Clin Exp Rheumatol. 2022;40(2): 274-283
  • Höppner J, Bruni C, Distler O, Robson SC, Burmester GR, Siegert E, Distler JHW: Purinergic signalling in systemic sclerosis. Rheumatology (Oxford). 2022;61(7): 2770-2782
  • Zhou X, Trinh-Minh T, Tran-Manh C, Gießl A, Bergmann C, Györfi AH, Schett G, Distler JHW: Impaired Mitochondrial Transcription Factor A Expression Promotes Mitochondrial Damage to Drive Fibroblast Activation and Fibrosis in Systemic Sclerosis. Arthritis Rheumatol. 2022;74(5): 871-881
  • Manfredi AA, Ramirez GA, Godino C, Capobianco A, Monno A, Franchini S, Tombetti E, Corradetti S, Distler JHW, Bianchi ME, Rovere-Querini P, Maugeri N: Platelet Phagocytosis via P-selectin Glycoprotein Ligand 1 and Accumulation of Microparticles in Systemic Sclerosis. Arthritis Rheumatol. 2022;74(2): 318-328
  • Kerick M, Acosta-Herrera M, Simeón-Aznar CP, Callejas JL, Assassi S, International SSc Group , Proudman SM, Nikpour M, Australian Scleroderma Interest Group (ASIG) , PRECISESADS Clinical Consortium , Hunzelmann N, Moroncini G, de Vries-Bouwstra JK, Orozco G, Barton A, Herrick AL, Terao C, Allanore Y, Fonseca C, Alarcón-Riquelme ME, Radstake TRDJ, Beretta L, Denton CP, Mayes MD, Martin J, Carreira P, Castellvi I, Ríos R, Portales RG, Fernández-Nebro A, García-Hernández FJ, Aguirre MA, Fernández-Gutiérrez B, Rodríguez-Rodríguez L, de la Peña PG, Vicente E, Andreu JL, de Castro MF, López-Longo FJ, Fonollosa V, Guillén A, Espinosa G, Tolosa C, Pros A, Beltrán E, Carballeira MR, Narváez FJ, Rivas MR, Ortiz-Santamaría V, Madroñero AB, González-Gay MA, Díaz B, Trapiella L, Egurbide MV, Fanlo-Mateo P, Saez-Comet L, Díaz F, Roman-Ivorra JA, Sancho JJA, Freire M, Garcia FJB, Oreiro N, Witte T, Kreuter A, Riemekasten G, Airò P, Magro C, Voskuyl AE, Vonk MC, Hesselstrand R, Nordin A, Lunardi C, Gabrielli A, Hoffmann-Vold A, Distler JHW, Padyukov L, Koeleman BPC, Stevens W, Zochling J, Sahhar J, Roddy J, Nash P, Tymms K, Rischmueller M, Lester S, Vigone B, Pers JO, Saraux A, Devauchelle-Pensec V, Cornec D, Jousse-Joulin S, Lauwerys B, Ducreux J, Maudoux AL, Vasconcelos C, Tavares A, Neves E, Faria R, Brandão M, Campar A, Marinho A, Farinha F, Almeida I, Mantecón MAG, Alonso RB, Martínez AC, Cervera R, Rodríguez-Pintó I, Espinosa G, Lories R, De Langhe E, Belz D, Witte T, Baerlecken N, Stummvoll G, Zauner M, Lehner M, Collantes E, Ortega-Castro R, Aguirre-Zamorano MA, Escudero-Contreras A, Castro-Villegas MC, Roldán MCF, Ortego N, Raya E, Moleón IJ, de Ramon E, Quintero ID, Meroni PL, Gerosa M, Schioppo T, Artusi C, Chizzolini C, Zuber A, Wynar D, Kovács L, Balog A, Deák M, Bocskai M, Dulic S, Kádár G, Hiepe F, Gerl V, Thiel S, Maresca MR, López-Berrio A, Aguilar-Quesada R, Navarro-Linares H: Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis. NPJ Genom Med. 2022;7(1):
  • Kuwana M, Allanore Y, Denton CP, Distler JH, Steen V, Khanna D, Matucci-Cerinic M, Mayes MD, Volkmann ER, Miede C, Gahlemann M, Quaresma Lic M, Alves M, Distler O: Nintedanib in Patients With Systemic Sclerosis-Associated Interstitial Lung Disease: Subgroup Analyses by Autoantibody Status and Modified Rodnan Skin Thickness Score. Arthritis Rheumatol. 2022;74(3): 518-526
  • Kuster S, Jordan S, Elhai M, Held U, Steigmiller K, Bruni C, Cacciapaglia F, Vettori S, Siegert E, Rednic S, Codullo V, Airo P, Braun-Moscovici Y, Hunzelmann N, Joao Salvador M, Riccieri V, Gheorghiu AM, Alegre Sancho JJ, Romanowska-Prochnicka K, Castellví I, Kötter I, Truchetet ME, López-Longo FJ, Novikov PI, Giollo A, Shirai Y, Belloli L, Zanatta E, Hachulla E, Smith V, Denton C, Ionescu RM, Schmeiser T, Distler JHW, Gabrielli A, Hoffmann-Vold AM, Kuwana M, Allanore Y, Distler O, EUSTAR collaborators , Becvar R, Cutolo M, Carreira PE, Czirják L, Iudici M, Kucharz EJ, Coleiro B, Bancel DF, Hesselstrand R, Radic M, Pellerito R, Damjanov N, Henes J, Vera Ortiz-Santamaria SH, Hasler P, Stamenkovic B, Selmi CF, Tikly M, Ananieva LP, Müller-Ladner U, Engelhart M, Puente C, Sunderkötter C, Ingegnoli F, Mouthon L, Cantatore FP, Ullman S, Pozzi MR, Wiland P, Vanthuyne M, Alegre-Sancho JJ, Krummel-Lorenz B, Herrmann K, Langhe E, Anic B, Yavuz S, Müller CS, Agachi S, Zenone T, Stebbings S, Vacca A, Stamp L, Solanki K, Veale D, Loyo E, Li M, Mohamed WAAA, Rosato E, Tanaseanu CM, Foti R, Ancuta C, Maurer B, Lefebvre PGP, Sibilia J, Litinsky I, Galdo FD, Seskute G, Saketkoo LA, Kerzberg E, Rimar D, Ribi C, Hsu VM, Martin T, Chung LS, Schmeiser T, Majewski D, Bernardino V, Puttini PS: Effectiveness and safety of tocilizumab in patients with systemic sclerosis: a propensity score matched controlled observational study of the EUSTAR cohort. RMD Open. 2022;8(2):
  • Bruni C, Heidenreich S, Duenas A, Hoffmann-Vold AM, Gabrielli A, Allanore Y, Chatelus E, Distler JHW, Hachulla E, Hsu VM, Hunzelmann N, Khanna D, Truchetet ME, Walker UA, Alves M, Schoof N, Saketkoo LA, Distler O: Patient preferences for the treatment of systemic sclerosis-associated interstitial lung disease: a discrete choice experiment. Rheumatology (Oxford). 2022;61(10): 4035-4046
  • Schmidt A, Fuchs M, Stojanović SD, Liang C, Schmidt K, Jung M, Xiao K, Weusthoff J, Just A, Pfanne A, Distler JHW, Dandekar T, Fiedler J, Thum T, Kunz M: Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling. Front Cardiovasc Med. 2022;9():
  • Matei AE, Marketa K, Gyorfi AH, Boxberger E, Soteriou D, Papava M, Muth J, Krater M, Schett G, Guck J, Distler JHW: CIRCULATING MONOCYTES HAVE DISTINCT PHYSICAL PROPERTIES THAT CORRELATE WITH DISEASE ACTIVITY AND SEVERITY AND PREDICT PROGRESSION IN SYSTEMIC SCLEROSIS Ann Rheum Dis. 2021;80 Suppl 1(): 1238-1238
  • Štorkánová H, Oreská S, Špiritović M, Heřmánková B, Bubová K, Komarc M, Pavelka K, Vencovský J, Distler JHW, Šenolt L, Bečvář R, Tomčík M: Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study. Sci Rep. 2021;11(1):
  • Storkanova H, Cerezo LA, Oreska S, Spiritovic M, Hermankova B, Komarc M, Pavelka K, Vencovsky J, Distler JHW, Senolt L, Becvar R, Tomcik M: S100A4 PLASMA LEVELS CORRELATE WITH DISEASE ACTIVITY, SKIN FIBROSIS AND INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS PATIENTS Ann Rheum Dis. 2021;80 Suppl 1(): 1233-1233
  • Xu X, Li YN, Chen CW, Trinh-Minh T, Schett G, Distler JHW: INACTIVATION OF ALDEHYDE DEHYDROGENASE 3A2 INHIBITS FIBROBLAST ACTIVATION AND TISSUE FIBROSIS Ann Rheum Dis. 2021;80 Suppl 1(): 391-391
  • Bergmann C, Hallenberger L, Chenguiti Fakhouri S, Merlevede B, Brandt A, Dees C, Zhu H, Zehender A, Zhou X, Schwab A, Chen CW, Györfi AH, Matei AE, Chakraborty D, Trinh-Minh T, Rauber S, Coras R, Bozec A, Kreuter A, Ziemer M, Schett G, Distler JHW: X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc). Ann Rheum Dis. 2021;80(8): 1048-1056
  • Zehender A, Li YN, Lin NY, Gyoerfi AH, Soare A, Bergmann C, Ramming A, Schett G, Distler JHW: INHIBITION OF AUTOPHAGY PREVENTS PROGRESSION OF FIBROSIS IN MURINE MODELS OF SYSTEMIC SCLEROSIS Ann Rheum Dis. 2021;80 Suppl 1(): 1075-1075
  • Highland KB, Distler O, Kuwana M, Allanore Y, Assassi S, Azuma A, Bourdin A, Denton CP, Distler JHW, Hoffmann-Vold AM, Khanna D, Mayes MD, Raghu G, Vonk MC, Gahlemann M, Clerisme-Beaty E, Girard M, Stowasser S, Zoz D, Maher TM, SENSCIS trial investigators: Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial. Lancet Respir Med. 2021;9(1): 96-106
  • Ross RL, Corinaldesi C, Migneco G, Carr IM, Antanaviciute A, Wasson CW, Carriero A, Distler JHW, Holmes S, El-Sherbiny YM, McKimmie CS, Del Galdo F: Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma. Ann Rheum Dis. 2021;80(7): 920-929
  • Zhang Y, Shen L, Dreissigacker K, Zhu H, Trinh-Minh T, Meng X, Tran-Manh C, Dees C, Matei AE, Chen CW, Ditschkowski M, Krauss S, Winkler J, Wolff D, Ziemer M, Beilhack A, Karrer S, Herr W, Mackensen A, Schett G, Spriewald BM, Distler JHW: Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease. Blood. 2021;137(17): 2403-2416
  • Chen CW, Li YN, Trinh-Minh T, Honglin Z, Matei AE, Ding X, Manh CT, Xu X, Liebel C, Liang R, Huang MC, Lin NY, Ramming A, Schett G, Distler JHW: DYNAMIC CHANGES IN O-GLCNACYLATION REGULATE OSTEOCLAST DIFFERENTIATION AND BONE LOSS IN ARTHRITIS Ann Rheum Dis. 2021;80 Suppl 1(): 121-122
  • Matei AE, Distler JHW: Response to: 'In search for the ideal anatomical composition of vascularised human skin equivalents for systemic sclerosis translational research: should we recruit the telocytes?' by Manetti and Matucci-Cerinic. Ann Rheum Dis. 2021;80(9):
  • Wollin L, Trinh-Minh T, Zhang Y, Distler JHW: The effect of nintedanib versus mycophenolate mofetil in the Fra2 mouse model of systemic sclerosis-associated interstitial lung disease. Clin Exp Rheumatol. 2021;39 Suppl 131(4): 134-141
  • Gyoerfi AH, Matei AE, Fuchs M, Rigau AR, Hong X, Honglin Z, Luber M, Bergmann C, Dees C, Ludolph I, Horch R, Distler O, Schett G, Kunz M, Distler JHW: ENGRAILED 1 COORDINATES CYTOSKELETAL ORGANIZATION TO PROMOTE MYOFIBROBLAST DIFFERENTIATION AND FIBROTIC TISSUE REMODELING Ann Rheum Dis. 2021;80 Suppl 1(): 391-391
  • Ly TD, Kleine A, Plümers R, Fischer B, Schmidt V, Hendig D, Distler JHW, Kuhn J, Knabbe C, Faust I: Cytokine-mediated induction of human xylosyltransferase-I in systemic sclerosis skin fibroblasts. Biochem Biophys Res Commun. 2021;549(): 34-39
  • Knitza J, Mohn J, Bergmann C, Kampylafka E, Hagen M, Bohr D, Morf H, Araujo E, Englbrecht M, Simon D, Kleyer A, Meinderink T, Vorbrüggen W, von der Decken CB, Kleinert S, Ramming A, Distler JHW, Vuillerme N, Fricker A, Bartz-Bazzanella P, Schett G, Hueber AJ, Welcker M: Accuracy, patient-perceived usability, and acceptance of two symptom checkers (Ada and Rheport) in rheumatology: interim results from a randomized controlled crossover trial. Arthritis Res Ther. 2021;23(1):
  • Maher T, Bourdin A, Volkmann E, Vettori S, Distler JHW, Alves M, Stock C, Distler O, SENSCIS Investigators: DECLINE IN FORCED VITAL CAPACITY (FVC) IN SUBJECTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE (SSC-ILD) IN THE SENSCIS TRIAL VERSUS HYPOTHETICAL REFERENCE SUBJECTS WITHOUT LUNG DISEASE Ann Rheum Dis. 2021;80 Suppl 1(): 671-672
  • Kuster S, Jordan S, Elhai MD, Held U, Steigmiller K, Bruni C, Iannone F, Vettori S, Siegert E, Rednic S, Codullo V, Airo P, Braun-Moscovici Y, Hunzelmann N, Salvador MJ, Riccieri V, Gheorghiu AM, Alegre Sancho JJA, Romanowska-Prochnicka K, Castellvi I, Koetter I, Truchetet ME, Lopez-Longo FJ, Novikov P, Giollo A, Shirai Y, Belloli L, Zanatta E, Hachulla E, Smith V, Denton C, Ionescu R, Schmeiser T, Distler JHW, Gabrielli A, Hoffmann-Vold AM, Kuwana M, Allanore Y, Distler O, EUSTAR: EFFECTIVENESS AND SAFETY OF TOCILIZUMAB IN PATIENTS WITH SYSTEMIC SCLEROSIS: A PROPENSITY SCORE CONTROL MATCHED OBSERVATIONAL STUDY OF THE EUSTAR COHORT Ann Rheum Dis. 2021;80 Suppl 1(): 685-686
  • Györfi AH, Matei AE, Fuchs M, Liang C, Rigau AR, Hong X, Zhu H, Luber M, Bergmann C, Dees C, Ludolph I, Horch RE, Distler O, Wang J, Bengsch B, Schett G, Kunz M, Distler JHW: Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation. J Exp Med. 2021;218(9):
  • Hesselstrand R, Distler JHW, Riemekasten G, Wuttge DM, Törngren M, Nyhlén HC, Andersson F, Eriksson H, Sparre B, Tuvesson H, Distler O: An open-label study to evaluate biomarkers and safety in systemic sclerosis patients treated with paquinimod. Arthritis Res Ther. 2021;23(1):
  • Soare A, Distler JHW: Untitled Reply Arthritis Rheumatol. 2021;73(1): 179-180
  • Zhang Y, Summa L, Heckmann B, Distler JHW: EFFECTS OF THE AUTOTAXIN INHIBITOR ZIRITAXESTAT ON SKIN AND LUNG FIBROSIS IN A MURINE GRAFT-VERSUS-HOST DISEASE MODEL OF SYSTEMIC SCLEROSIS Ann Rheum Dis. 2021;80 Suppl 1(): 148-149
  • Hirschmann S, Fischer S, Klenske E, Dechant K, Distler JHW, Treutlein C, Neurath MF, Atreya R: Case report of severe constrictive perimyocarditis and ischemic hepatitis in a Crohn's disease patient upon infliximab-induced lupus-like syndrome. Therap Adv Gastroenterol. 2021;14():
  • Rius Rigau A, Luber M, Distler JHW: Mouse Models of Skin Fibrosis. Methods Mol Biol. 2021;2299(): 371-383
  • Acosta-Herrera M, Kerick M, Lopéz-Isac E, Assassi S, Beretta L, Simeón-Aznar CP, Ortego-Centeno N, International SSc Group , Proudman SM, Australian Scleroderma Interest Group (ASIG) , Hunzelmann N, Moroncini G, de Vries-Bouwstra JK, Orozco G, Barton A, Herrick AL, Terao C, Allanore Y, Brown MA, Radstake TR, Fonseca C, Denton CP, Mayes MD, Martin J, Carreira P, Castellvi I, Ríos R, Callejas JL, García Portales R, Fernández-Nebro A, García-Hernández FJ, Aguirre MA, Fernández-Gutiérrez B, Rodríguez-Rodríguez L, García de la Peña P, Vicente E, Andreu JL, Fernández de Castro M, López-Longo FJ, Fonollosa V, Guillén A, Espinosa G, Tolosa C, Pros A, Beltrán E, Rodríguez Carballeira M, Narváez FJ, Rubio Rivas M, Ortiz-Santamaría V, Madroñero AB, González-Gay MA, Díaz B, Trapiella L, Egurbide MV, Fanlo-Mateo P, Saez-Comet L, Díaz F, Roman-Ivorra JA, Alegre Sancho JJ, Freire M, Blanco Garcia FJ, Oreiro N, Witte T, Kreuter A, Riemekasten G, Airo P, Magro C, Voskuyl AE, Vonk MC, Hesselstrand R, Nordin A, Lunardi C, Gabrielli A, Hoffmann-Vold A, Distler JHW, Padyukov L, Koeleman B, Stevens W, Nikpour M, Zochling J, Sahhar J, Roddy J, Nash P, Tymms K, Rischmueller M, Lester S: Comprehensive analysis of the major histocompatibility complex in systemic sclerosis identifies differential HLA associations by clinical and serological subtypes. Ann Rheum Dis. 2021;80(8): 1040-1047
  • Dees C, Chakraborty D, Distler JHW: Cellular and molecular mechanisms in fibrosis. Exp Dermatol. 2021;30(1): 121-131
  • Bruni C, Heidenreich S, Duenas A, Hoffmann-Vold AM, Gabrielli A, Allanore Y, Chatelus E, Distler JHW, Hachulla E, Hsu V, Hunzelmann N, Khanna D, Truchetet ME, Walker U, Alves M, Schoof N, Saketkoo LA, Distler O: PATIENT PREFERENCES, TRADE-OFFS AND ACCEPTABLE RISKS IN THE TREATMENT OF SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE: A STEP TOWARDS SHARED DECISION-MAKING Ann Rheum Dis. 2021;80 Suppl 1(): 681-682
  • Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW: TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. Nat Commun. 2021;12(1):
  • Györfi AH, Kopp M, May M, Vetter M, Uder M, Kremer AE, Schett G, Harrer T, Distler JHW: Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis. Ann Rheum Dis. 2021;80(6):
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Autophagy. 2021;17(1): 1-382
  • Dobrota R, Jordan S, Juhl P, Maurer B, Wildi L, Bay-Jensen AC, Karsdal MA, Herrick AL, Distler JHW, Allanore Y, Hoffmann-Vold AM, Siebuhr AS, Distler O: Circulating collagen neo-epitopes and their role in the prediction of fibrosis in patients with systemic sclerosis: a multicentre cohort study Lancet Rheumatol.. 2021;3(3): E175-E184
  • Wollin L, Trinh-Minh T, Zhang Y, Distler JHW: The effect of nintedanib versus mycophenolate mofetil in the Fra2 mouse model of systemic sclerosis-associated interstitial lung disease Clin Exp Rheumatol. 2021;39 Suppl 131(4): S134-S141
  • Distler JHW, Bergmann C, Kuwert T, Schmidkonz C: Quantification of Ga-68-FAPI-04 in systemic sclerosis-associated interstitial lung disease Reply Lancet Rheumatol.. 2021;3(7): E475-E477
  • Chakraborty D, Šumová B, Mallano T, Chen CW, Distler A, Bergmann C, Ludolph I, Horch RE, Gelse K, Ramming A, Distler O, Schett G, Šenolt L, Distler JHW: Author Correction: Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis. Nat Commun. 2021;12(1):
  • Štorkánová H, Štorkánová L, Navrátilová A, Bečvář V, Hulejová H, Oreská S, Heřmánková B, Špiritović M, Bečvář R, Pavelka K, Vencovský J, Distler JHW, Šenolt L, Tomčík M: Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin. Biomedicines. 2021;9(6):
  • Duffy L, Henderson J, Brown M, Pryzborski S, Fullard N, Summa L, Distler JHW, Stratton R, O'Reilly S: Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis. Front Cell Dev Biol. 2021;9():
  • Stegemann A, Flis D, Ziolkowski W, Distler JHW, Steinbrink K, Böhm M: The α7 Nicotinic Acetylcholine Receptor: A Promising Target for the Treatment of Fibrotic Skin Disorders. J Invest Dermatol. 2020;140(12): 2371-2379
  • Knitza J, Cavagna L, Schett G, Distler JHW: Comment on: 'Idiopathic inflammatory myopathies and antisynthetase syndrome: contribution of antisynthetase antibodies to improve current classification criteria' by Greco et al. Ann Rheum Dis. 2020;79(7):
  • Worrell JC, Leslie J, Smith GR, Zaki MYW, Paish HL, Knox A, James ML, Cartwright TN, O'Reilly S, Kania G, Distler O, Distler JHW, Herrick AL, Jeziorska M, Borthwick LA, Fisher AJ, Mann J, Mann DA, Oakley F: cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis. Rheumatology (Oxford). 2020;59(12): 3939-3951
  • Alexander T, Henes J, Distler JHW, Schmalzing M, Blank N, Kötter I, Hiepe F: [Autologous hematopoietic stem cell transplantation for systemic sclerosis : Position statement of the stem cell therapy working party of the German Society of Rheumatology]. Z Rheumatol. 2020;79(5): 429-436
  • Bütikofer L, Varisco PA, Distler O, Kowal-Bielecka O, Allanore Y, Riemekasten G, Villiger PM, Adler S, EUSTAR collaborators , Avouac J, Walker UA, Guiducci S, Riemekasten G, Airò P, Hachulla E, Valentini G, Carreira PE, Cozzi F, Gurman AB, Braun-Moscovici Y, Damjanov N, Ananieva LP, Scorza R, Jimenez S, Busquets J, Li M, Müller-Ladner U, Maurer B, Tyndall A, Lapadula G, Iannone F, Becvar R, Sierakowsky S, Bielecka OK, Cutolo M, Sulli A, Cuomo G, Vettori S, Rednic S, Nicoara I, Vlachoyiannopoulos P, Montecucco C, Caporali R, Novak S, Czirják L, Varju C, Chizzolini C, Kucharz EJ, Kotulska A, Kopec-Medrek M, Widuchowska M, Rozman B, Mallia C, Coleiro B, Gabrielli A, Farge D, Hij A, Hesselstrand R, Scheja A, Wollheim F, Martinovic D, Govoni M, Monaco AL, Hunzelmann N, Pellerito R, Bambara LM, Caramaschi P, Black C, Denton C, Henes J, Santamaria VO, Heitmann S, Krasowska D, Seidel M, Oleszowsky M, Burkhardt H, Himsel A, Salvador MJ, Stamenkovic B, Stankovic A, Tikly M, Starovoytova MN, Engelhart M, Strauss G, Nielsen H, Damgaard K, Szücs G, Mendoza AZ, de la Puente Buijdos C, Sifuentes Giraldo WA, Midtvedt Ø, Garen T, Launay D, Valesini G, Riccieri V, Ionescu RM, Opris D, Groseanu L, Wigley FM, Mihai CM, Cornateanu RS, Ionitescu R, Gherghe AM, Gorga M, Dobrota R, Bojinca M, Schett G, Distler JHW, Meroni P, Zeni S, Mouthon L, De Keyser F, Smith V, Cantatore FP, Corrado A, Ullman S, Iversen L, Pozzi MR, Eyerich K, Hein R, Knott E, Szechinski J, Wiland P, Szmyrka-Kaczmarek M, Sokolik R, Morgiel E, Krummel-Lorenz B, Saar P, Aringer M, Günther C, Anic B, Baresic M, Mayer M, Radominski SC, de Souza Müller C, Azevedo VF, Agachi S, Groppa L, Chiaburu L, Russu E, Zenone T, Stebbings S, Highton J, Stamp L, Chapman P, Baron M, O'Donnell J, Solanki K, Doube A, Veale D, O'Rourke M, Loyo E, Rosato E, Pisarri S, Tanaseanu CM, Popescu M, Dumitrascu A, Tiglea I, Chirieac R, Ancuta C, Furst DE, Kafaja S, de la Peña Lefebvre PG, Rubio SR, Exposito MV, Sibilia J, Chatelus E, Gottenberg JE, Chifflot H, Litinsky I, Venalis A, Butrimiene I, Venalis P, Rugiene R, Karpec D, Kerzberg E, Montoya F, Cosentino V, Castellvi I: ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis. Arthritis Res Ther. 2020;22(1):
  • Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, Distler O: Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis. J Clin Invest. 2020;130(9): 4888-4905
  • Moinzadeh P, Kuhr K, Siegert E, Blank N, Sunderkoetter C, Henes J, Krusche M, Schmalzing M, Worm M, Schmeiser T, Günther C, Aberer E, Susok L, Riemekasten G, Kreuter A, Zeidler G, Juche A, Hadjiski D, Müller-Ladner U, Gaebelein-Wissing N, Distler JHW, Sárdy M, Krieg T, Hunzelmann N: Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication. J Rheumatol. 2020;47(2): 241-248
  • Jaeger VK, Tikly M, Xu D, Siegert E, Hachulla E, Airò P, Valentini G, Matucci Cerinic M, Distler O, Cozzi F, Carreira P, Allanore Y, Müller-Ladner U, Ananieva LP, Balbir-Gurman A, Distler JHW, Czirják L, Li M, Henes J, Jimenez SA, Smith V, Damjanov N, Denton CP, DelGaldo F, Saketkoo LA, Walker UA, and EUSTAR co-authors: Racial differences in systemic sclerosis disease presentation: a European Scleroderma Trials and Research group study. Rheumatology (Oxford). 2020;59(7): 1684-1694
  • González-Serna D, Ochoa E, López-Isac E, Julià A, Degenhardt F, Ortego-Centeno N, Radstake TRDJ, Franke A, Marsal S, Mayes MD, Martín J, Márquez A, Scleroderma Genetic Consortium , Assassi S, Zhou X, Tan FK, Arnett FC, Reveille JD, Gorlova O, Chen WV, Ying J, Gregersen PK, Lee AT, Voskuyl AE, de Vries-Bouwstra J, Magro-Checa C, Broen J, Koeleman BPC, Simeón CP, Fonollosa V, Guillén A, Carreira P, Castellví I, González-Gay MA, Ríos R, Callejas-Rubio JL, Vargas-Hitos JA, García-Portales R, Camps MT, Fernández-Nebro A, González-Escribano MF, García-Hernández FJ, Castillo MJ, Aguirre MÁ, Gómez-Gracia I, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, de la Peña PG, Vicente E, Andreu JL, Fernández de Castro M, López-Longo FJ, Martínez L, Espinosa G, Tolosa C, Pros A, Rodríguez-Carballeira M, Narváez FJ, Rubio-Rivas M, Ortiz-Santamaría V, Madroñero AB, Díaz B, Trapiella L, Sousa A, Egurbide MV, Fanlo-Mateo P, Sáez-Comet L, Díaz-González F, Hernández V, Beltrán E, Román-Ivorra JA, Grau E, Alegre-Sancho JJ, Blanco-García FJ, Oreiro N, Freire M, Balsa A, Ortiz AM, Hunzelmann N, Riemekasten G, Distler JHW, Witte T, Airó P, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A: A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease. Sci Rep. 2020;10(1):
  • Hoffmann-Vold AM, Maher TM, Philpot EE, Ashrafzadeh A, Barake R, Barsotti S, Bruni C, Carducci P, Carreira PE, Castellvi I, Del Galdo F, Distler JHW, Foeldvari I, Fraticelli P, George PM, Griffiths B, Guillen-Del-Castillo A, Hamid AM, Horvath R, Hughes M, Kreuter M, Moazedi-Fuerst F, Olas J, Paul S, Rotondo C, Rubio-Rivas M, Seferian A, Tomcik M, Uzunhan Y, Walker UA, Wiesik-Szewczyk E, Distler O: The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements Lancet Rheumatol.. 2020;2(2): E71-E83
  • Soare A, Gyoerfi HA, Matei AE, Dees C, Rauber S, Wohlfahrt T, Chen CW, Ludolph I, Horch RE, Baeuerle T, von Hoersten S, Mihai C, Distler O, Ramming A, Schett G, Distler JHW: Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis Arthritis Rheumatol. 2020;72(1): 137-149
  • Renoux F, Stellato M, Haftmann C, Vogetseder A, Huang R, Subramaniam A, Becker MO, Blyszczuk P, Becher B, Distler JHW, Kania G, Boyman O, Distler O: The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development. Cell Rep. 2020;31(13):
  • Ledein L, Léger B, Dees C, Beyer C, Distler A, Vettori S, Boukaiba R, Bidouard JP, Schaefer M, Pernerstorfer J, Ruetten H, Jagerschmidt A, Janiak P, Distler JHW, Distler O, Illiano S: Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse. Br J Pharmacol. 2020;177(18): 4296-4309
  • Distler O, Assassi S, Cottin V, Cutolo M, Danoff SK, Denton CP, Distler JHW, Hoffmann-Vold AM, Johnson SR, Müller Ladner U, Smith V, Volkmann ER, Maher TM: Predictors of progression in systemic sclerosis patients with interstitial lung disease. Eur Respir J. 2020;55(5):
  • Matteson E, Distler O, Distler JHW, Kuwana M, Pope J, Seibold J, James A, Schlenker-Herceg R, Rohr K, Flaherty K: Reduced Decline in Forced Vital Capacity in Patients with Progressive Fibrosing Autoimmune Disease-Related Interstitial Lung Diseases (ILDs) Treated with Nintedanib Arthritis Rheumatol. 2020;72 Suppl 10():
  • Wuyts WA, Azuma A, Distler JHW, Sondergaard K, Proudman S, Cottin V, Erhardt E, Quaresma M, Gahlemann M, Alves M, Maher TM: Effects of nintedanib in patients with SSc-ILD and preserved and highly impaired lung function Eur Respir J. 2020;56 Suppl 64():
  • Storkanova H, Storkanova L, Oreska S, Spiritovic M, Hermankova B, Becvar R, Pavelka K, Vencovsky J, Distler JHW, Senolt L, Tomcik M: Hsp90 Inhibition Effectively Prevents Progression of Dermal Fibrosis and Induces Regression of Established Bleomycin-Induced Dermal Fibrosis Arthritis Rheumatol. 2020;72 Suppl 10():
  • Moinzadeh P, Kuhr K, Siegert E, Mueller-Ladner U, Riemekasten G, Günther C, Kötter I, Henes J, Blank N, Zeidler G, Pfeiffer C, Juche A, Jandova I, Ehrchen J, Schmalzing M, Susok L, Schmeiser T, Sunderkoetter C, Distler JHW, Worm M, Kreuter A, Krieg T, Hunzelmann N, Registry of the German Network for Systemic Scleroderma: Older age onset of systemic sclerosis - accelerated disease progression in all disease subsets. Rheumatology (Oxford). 2020;59(11): 3380-3389
  • Dees C, Pötter S, Zhang Y, Bergmann C, Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, Gelse K, Yoshimura A, Jaenisch R, Distler O, Schett G, Distler JH: TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis. J Clin Invest. 2020;130(5): 2347-2363
  • Zhang Y, Shen L, Zhu H, Dreissigacker K, Distler D, Zhou X, Györfi AH, Bergmann C, Meng X, Dees C, Trinh-Minh T, Ludolph I, Horch R, Ramming A, Schett G, Distler JHW: PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis. Ann Rheum Dis. 2020;79(9): 1227-1233
  • Schmidkonz C, Rauber S, Atzinger A, Agarwal R, Götz TI, Soare A, Cordes M, Prante O, Bergmann C, Kleyer A, Ritt P, Maschauer S, Hennig P, Toms J, Köhner M, Manger B, Stone JH, Haberkorn U, Baeuerle T, Distler JHW, Agaimy A, Kuwert T, Schett G, Ramming A: Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging. Ann Rheum Dis. 2020;79(11): 1485-1491
  • Zhang Y, Zhu H, Layritz F, Luo H, Wohlfahrt T, Chen CW, Soare A, Bergmann C, Ramming A, Groeber F, Reuter C, Fornasini G, Soukhareva N, Schreiber B, Ramamurthy S, Amann K, Schett G, Distler JHW: Recombinant Adenosine Deaminase Ameliorates Inflammation, Vascular Disease, and Fibrosis in Preclinical Models of Systemic Sclerosis. Arthritis Rheumatol. 2020;72(8): 1385-1395
  • Chakraborty D, Zhu H, Jüngel A, Summa L, Li YN, Matei AE, Zhou X, Huang J, Trinh-Minh T, Chen CW, Lafyatis R, Dees C, Bergmann C, Soare A, Luo H, Ramming A, Schett G, Distler O, Distler JHW: Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis. Sci Transl Med. 2020;12(563):
  • Liang RF, Kagwiria R, Zehender A, Dees C, Bergmann C, Ramming A, Krasowska D, Michalska-Jakubus M, Kreuter A, Kraner ME, Schett G, Distler JHW: Acyltransferase skinny hedgehog regulates TGF beta-dependent fibroblast activation in SSc Ann Rheum Dis. 2019;78(9): 1269-1273
  • Codullo V, Cova E, Pandolfi L, Breda S, Morosini M, Frangipane V, Malatesta M, Calderan L, Cagnone M, Pacini C, Cavagna L, Recalde H, Distler JHW, Giustra M, Prosperi D, Colombo M, Meloni F, Montecucco C: Imatinib-loaded gold nanoparticles inhibit proliferation of fibroblasts and macrophages from systemic sclerosis patients and ameliorate experimental bleomycin-induced lung fibrosis J Control Release. 2019;310(): 198-208
  • Matei AE, Chen CW, Kiesewetter L, Gyoerfi AH, Li YN, Thuong Trinh-Minh TM, Xu XH, Cuong Tran Manh CT, van Kuppevelt T, Hansmann J, Jungel A, Schett G, Groeber-Becker F, Distler JHW: Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs Ann Rheum Dis. 2019;78(12): 1686-1692
  • Lopez-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeon CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, David Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B, Rios R, Callejas JL, Vargas-Hitos JA, Garcia-Portales R, Camps MT, Fernandez-Nebro A, Gonzalez-Escribano MF, Garcia-Hernandez FJ, Castillo MJ, Aguirre MA, Gomez-Gracia I, Fernandez-Gutierrez B, Rodriguez-Rodriguez L, Garcia de la Pena PG, Vicente E, Andreu JL, Fernandez de Castro MF, Lopez-Longo FJ, Martinez L, Fonollosa V, Guillen A, Espinosa G, Tolosa C, Pros A, Rodriguez-Carballeira M, Narvaez FJ, Rubio-Rivas M, Ortiz-Santamaria V, Madronero AB, Gonzalez-Gay MA, Diaz B, Trapiella L, Sousa A, Egurbide MV, Fanlo-Mateo P, Saez-Comet L, Diaz F, Hernandez V, Beltran E, Roman-Ivorra JA, Grau E, Alegre-Sancho JJ, Freire M, Blanco-Garcia FJ, Oreiro N, Witte T, Kreuter A, Riemekasten G, Airo P, Magro C, Voskuyl AE, Vonk MC, Hesselstrand R, Proudman S, Stevens W, Nikpour M, Zochling J, Sahhar J, Roddy J, Nash P, Tymms K, Rischmueller M, Lester S, Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J, European Scleroderma Grp ASIG: GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways Nat Commun. 2019;10():
  • Kreuter M, Bonella F, Blank N, Siegert E, Henes J, Worm M, Sunderkoetter C, Schmalzing M, Kreuter A, Guenther C, Susok L, Zeidler G, Koetter I, Mueller-Ladner U, Krieg T, Juche A, Schmeiser T, Riemekasten G, Aberer E, Gaebelein-Wissing N, Distler JHW, Sardy M, Pfeiffer C, Kuhr K, Lorenz H, Moinzadeh P, Hunzelmann N: Predictors for the Development of Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD) - Data from the German SSc-Network Am J Respir Crit Care Med. 2019;199():
  • Kozlova A, Pachera E, Maurer B, Juengel A, Distler JHW, Kania G, Distler O: Regulation of Fibroblast Apoptosis and Proliferation by MicroRNA-125b in Systemic Sclerosis Arthritis Rheumatol. 2019;71(12): 2068-2080
  • Kreuter M, Bonella F, Blank N, Siegert E, Henes J, Worm M, Sunderkoetter C, Schmalzing M, Kreuter A, Guenther C, Susok L, Zeidler G, Koetter I, Mueller-Ladner U, Krieg T, Juche A, Schmeiser T, Riemekasten G, Aberer E, Gaebelein-Wissing N, Distler JHW, Sardy M, Pfeiffer C, Kuhr K, Lorenz HM, Moinzadeh P, Hunzelmann N: Does anti-acid treatment influence disease progression in SSc-ILD ? data from the German SSc-network Eur Respir J. 2019;54():
  • Kreuter M, Bonella F, Blank N, Siegert E, Henes J, Worm M, Sunderkoetter C, Schmalzing M, Kreuter A, Guenther C, Susok L, Zeidler G, Koetter I, Mueller-Ladner U, Krieg T, Juche A, Schmeiser T, Riemekasten G, Aberer E, Gaebelein-Wissing N, Distler JHW, Sardy M, Pfeiffer C, Kuhr K, Lorenz HM, Moinzadeh P, Hunzelmann N: Long term outcomes of immunomodulatory drugs in SSc-ILD - data from the German SSc-network Eur Respir J. 2019;54():
  • Fasano S, Riccardi A, Messiniti V, Caramaschi P, Rosato E, Maurer B, Smith V, Siegert E, De Langhe E, Riccieri V, Airo P, Mihai C, Avouac J, Zanatta E, Walker UA, Iannone F, De la Pena Lefebvre PGD, Distler JHW, Vacca A, Distler O, Kowal-Bielecka O, Allanore Y, Valentini G: Revised European Scleroderma Trials and Research Group Activity Index is the best predictor of short-term severity accrual Ann Rheum Dis. 2019;78(12): 1681-1685
  • Distler JHW, Gyoerfi AH, Ramanujam M, Whitfield ML, Koenigshoff M, Lafyatis R: Shared and distinct mechanisms of fibrosis Nat Rev Rheumatol. 2019;15(12): 705-730
  • Wollin L, Distler JHW, Redente EF, Riches DWH, Stowasser S, Schlenker-Herceg R, Maher TM, Kolb M: Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases Eur Respir J. 2019;54(3):
  • Wohlfahrt T, Rauber S, Uebe S, Luber M, Soare A, Ekici A, Weber S, Matei AE, Chen CW, Maier C, Karouzakis E, Kiener HP, Pachera E, Dees C, Beyer C, Daniel C, Gelse K, Kremer AE, Naschberger E, Stürzl M, Butter F, Sticherling M, Finotto S, Kreuter A, Kaplan MH, Jüngel A, Gay S, Nutt SL, Boykin DW, Poon GMK, Distler O, Schett G, Distler JHW, Ramming A: PU.1 controls fibroblast polarization and tissue fibrosis. Nature. 2019;566(7744): 344-349
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