Prof. Dr. G. Krönke

Publications: Prof. Dr. med. G. Krönke

Rech J, Tascilar K, Hagen M, Kleyer A, Manger B, Schoenau V, Hueber AJ, Kleinert S, Baraliakos X, Braun J, Kiltz U, Fleck M, Rubbert-Roth A, Kofler DM, Behrens F, Feuchtenberger M, Zaenker M, Voll R, Venhoff N, Thiel J, Glaser C, Feist E, Burmester GR, Karberg K, Strunk J, Cañete JD, Senolt L, Filkova M, Naredo E, Largo R, Krönke G, D'Agostino MA, Østergaard M, Schett G: Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial. Lancet. 2024;403(10429): 850-859
Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A: Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Nat Commun. 2024;15(1):
Puchner A, Simader E, Saferding V, Hofmann M, Kieler M, Brunner J, Pfeifle R, Niederreiter B, Krönke G, Schabbauer G, Georgel P, Diehl G, Steiner G, Hayer S, Redlich K, Smolen JS, Aletaha D, Blüml S: Bona fide dendritic cells are pivotal precursors for osteoclasts. Ann Rheum Dis. 2024;83(4): 518-528
Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D: Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography. Rheumatology (Oxford). 2023;62(2): 841-849
Yalcin Mutlu M, Wacker J, Tascilar K, Taubmann J, Manger B, Krönke G, Schett G, Simon D: Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus-associated refractory cerebral vasculitis induces immune tolerance. Rheumatology (Oxford). 2023;62(2): e21-e23
Kretschmann S, Völkl S, Reimann H, Krönke G, Schett G, Achenbach S, Lutzny-Geier G, Müller F, Mougiakakos D, Dingfelder J, Flamann C, Hanssens L, Gary R, Mackensen A, Aigner M: Successful Generation of CD19 Chimeric Antigen Receptor T Cells from Patients with Advanced Systemic Lupus Erythematosus. Transplant Cell Ther. 2023;29(1): 27-33
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R: Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 2023;15(2):
Reimann H, Kremer AN, Blumenberg V, Schmidt KG, Aigner M, Jacobs B, Eisenhauer N, Kämpf A, Roesler W, Kharboutli S, Mougiakakos D, Lang V, Lischer C, Irrgang P, Leppkes M, Gonzalez JV, Krönke G, Kremer AE, Tenbusch M, Bruns H, Harrer T, Müller F, Schett G, Mackensen A, Subklewe M, Völkl S: Cellular and humoral immune responses to SARS-CoV-2 vaccination in patients after CD19.CAR T-cell therapy. Blood Adv. 2023;7(10): 2066-2069
Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhöfer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann MH, Krönke G: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. J Exp Med. 2023;220(6):
Müller F, Boeltz S, Knitza J, Aigner M, Völkl S, Kharboutli S, Reimann H, Taubmann J, Kretschmann S, Rösler W, Manger B, Wacker J, Mougiakakos D, Jabari S, Schröder R, Uder M, Roemer F, Krönke G, Mackensen A, Schett G: CD19-targeted CAR T cells in refractory antisynthetase syndrome. Lancet. 2023;401(10379): 815-818
Simon D, Minopoulou I, Kemenes S, Bayat S, Tascilar K, Mutlu MY, Valor-Méndez L, Krönke G, Hueber AJ, Schett G, Kleyer A: Baricitinib Improves Bone Properties and Biomechanics in Patients With Rheumatoid Arthritis: Results of the Prospective Interventional BARE BONE Trial. Arthritis Rheumatol. 2023;75(11): 1923-1934
Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhöfer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann MH, Krönke G: Addendum: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. J Exp Med. 2023;220(7):
Peckert-Maier K, Wild AB, Sprißler L, Fuchs M, Beck P, Auger JP, Sinner P, Strack A, Mühl-Zürbes P, Ramadan N, Kunz M, Krönke G, Stich L, Steinkasserer A, Royzman D: Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism. Front Immunol. 2023;14():
Mackensen A, Mueller F, Mougiakakos D, Boltz S, Wilhelm A, Aigner M, Volkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rosler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Kronke G, Schett G: Author Correction: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2023;29(11):
Muehlensiepen F, May S, Hadaschik K, Vuillerme N, Heinze M, Grahammer M, Labinsky H, Boeltz S, Detert J, Petersen J, Krönke G, Schett G, Knitza J: Digitally supported shared decision-making and treat-to-target in rheumatology: a qualitative study embedded in a multicenter randomized controlled trial. Rheumatol Int. 2023;43(4): 695-703
Simon D, Tascilar K, Kleyer A, Fagni F, Krönke G, Meder C, Dietrich P, Orlemann T, Kliem T, Mößner J, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G: Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS-CoV-2 in an Unvaccinated Cohort. Arthritis Rheumatol. 2022;74(5): 783-790
Muehlensiepen F, May S, Zarbl J, Vogt E, Boy K, Heinze M, Boeltz S, Labinsky H, Bendzuck G, Korinth M, Elling-Audersch C, Vuillerme N, Schett G, Krönke G, Knitza J: At-home blood self-sampling in rheumatology: a qualitative study with patients and health care professionals. BMC Health Serv Res. 2022;22(1):
Stenzel R, Hadaschik K, May S, Grahammer M, Labinsky H, Welcker M, Hornig J, Bendzuck G, Elling-Audersch C, Erstling U, Korbanka PS, Vuillerme N, Heinze M, Krönke G, Schett G, Pecher AC, Krusche M, Mucke J, Knitza J, Muehlensiepen F: Digitally-supported patient-centered asynchronous outpatient follow-up in rheumatoid arthritis - an explorative qualitative study. BMC Health Serv Res. 2022;22(1):
Zarbl J, Eimer E, Gigg C, Bendzuck G, Korinth M, Elling-Audersch C, Kleyer A, Simon D, Boeltz S, Krusche M, Mucke J, Muehlensiepen F, Vuillerme N, Krönke G, Schett G, Knitza J: Remote self-collection of capillary blood using upper arm devices for autoantibody analysis in patients with immune-mediated inflammatory rheumatic diseases. RMD Open. 2022;8(2):
Simon D, Tascilar K, Fagni F, Schmidt K, Krönke G, Kleyer A, Ramming A, Schoenau V, Bohr D, Knitza J, Harrer T, Manger K, Manger B, Schett G: Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease. Ann Rheum Dis. 2022;81(7): 1023-1027
Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G: Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion. Arthritis Rheumatol. 2022;74(1): 33-37
Schmetzer C, Vogt E, Stellar L, Godonou ET, Liphardt AM, Muehlensiepen F, Vuillerme N, Hueber AJ, Kleyer A, Krönke G, Schett G, Simon D, Knitza J: Self-collection of capillary blood and saliva to determine COVID-19 vaccine immunogenicity in patients with immune-mediated inflammatory diseases and health professionals. Front Public Health. 2022;10():
Folle L, Bayat S, Kleyer A, Fagni F, Kapsner LA, Schlereth M, Meinderink T, Breininger K, Tacilar K, Krönke G, Uder M, Sticherling M, Bickelhaupt S, Schett G, Maier A, Roemer F, Simon D: Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis. Rheumatology (Oxford). 2022;61(12): 4945-4951
Simon D, Tascilar K, Fagni F, Kleyer A, Krönke G, Meder C, Dietrich P, Orlemann T, Mößner J, Taubmann J, Mutlu MY, Knitza J, Kemenes S, Liphardt AM, Schönau V, Bohr D, Schuster L, Hartmann F, Minopoulou I, Leppkes M, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Atreya R, Berking C, Sticherling M, Neurath MF, Schett G: Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study. Lancet Rheumatol.. 2022;4(9): e614-e625
Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2022;28(10): 2124-2132
Bayat S, Tascilar K, Bohr D, Krönke G, Simon D, Knitza J, Hartmann F, Schett G, Kleyer A: Efficacy and drug persistence of baricitinib monotherapy is similar to combination therapy in patients with active RA: a prospective observational study. RMD Open. 2022;8(2):
Meng X, Lin Z, Cao S, Janowska I, Sonomoto K, Andreev D, Katharina K, Wen J, Knaup KX, Wiesener MS, Krönke G, Rizzi M, Schett G, Bozec A: Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res. 2022;10(1):
Knitza J, Tascilar K, Vuillerme N, Eimer E, Matusewicz P, Corte G, Schuster L, Aubourg T, Bendzuck G, Korinth M, Elling-Audersch C, Kleyer A, Boeltz S, Hueber AJ, Krönke G, Schett G, Simon D: Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial. Arthritis Res Ther. 2022;24(1):
Folle L, Simon D, Tascilar K, Krönke G, Liphardt AM, Maier A, Schett G, Kleyer A: Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns-How Neural Networks Can Tell Us Where to "Deep Dive" Clinically. Front Med (Lausanne). 2022;9():
Studenic P, Hensvold A, Kleyer A, van der Helm-van Mil A, Pratt AG, Sieghart D, Krönke G, Williams R, de Souza S, Karlfeldt S, Johannesson M, Krogh NS, Klareskog L, Catrina AI: Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry. Front Med (Lausanne). 2022;9():
Knab K, Chambers D, Krönke G: Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation. Front Med (Lausanne). 2022;9():
Vodencarevic A, Tascilar K, Hartmann F, Reiser M, Hueber AJ, Haschka J, Bayat S, Meinderink T, Knitza J, Mendez L, Hagen M, Krönke G, Rech J, Manger B, Kleyer A, Zimmermann-Rittereiser M, Schett G, Simon D, RETRO study group: Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs. Arthritis Res Ther. 2021;23(1):
Simon D, Tascilar K, Fagni F, Krönke G, Kleyer A, Meder C, Atreya R, Leppkes M, Kremer AE, Ramming A, Pachowsky ML, Schuch F, Ronneberger M, Kleinert S, Hueber AJ, Manger K, Manger B, Berking C, Sticherling M, Neurath MF, Schett G: SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases. Ann Rheum Dis. 2021;80(10): 1312-1316
Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021;54(11): 2531-2546.e5
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH: The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. 2021;54(5): 1002-1021.e10
Folle L, Meinderink T, Simon D, Liphardt AM, Krönke G, Schett G, Kleyer A, Maier A: Deep learning methods allow fully automated segmentation of metacarpal bones to quantify volumetric bone mineral density. Sci Rep. 2021;11(1):
Mougiakakos D, Krönke G, Schett G: More on CD19-CAR T Cells in Systemic Lupus Erythematosus. Reply. N Engl J Med. 2021;385(19):
Mougiakakos D, Krönke G, Völkl S, Kretschmann S, Aigner M, Kharboutli S, Böltz S, Manger B, Mackensen A, Schett G: CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus. N Engl J Med. 2021;385(6): 567-569
Ghoreschi K, Augustin M, Baraliakos X, Krönke G, Schneider M, Schreiber S, Schulze-Koops H, Zeißig S, Thaçi D: TYK2 inhibition and its potential in the treatment of chronic inflammatory immune diseases. J Dtsch Dermatol Ges. 2021;19(10): 1409-1420
Spoerl S, Kremer AN, Aigner M, Eisenhauer N, Koch P, Meretuk L, Löffler P, Tenbusch M, Maier C, Überla K, Heinzerling L, Frey B, Lutzny-Geier G, Winkler TH, Krönke G, Vetter M, Bruns H, Neurath MF, Mackensen A, Kremer AE, Völkl S: Upregulation of CCR4 in activated CD8+ T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection. Eur J Immunol. 2021;51(6): 1436-1448
Friedrich B, Auger JP, Dutz S, Cicha I, Schreiber E, Band J, Boccacccini AR, Krönke G, Alexiou C, Tietze R: Hydroxyapatite-Coated SPIONs and Their Influence on Cytokine Release. Int J Mol Sci. 2021;22(8):
Mucke J, Knitza J, Muehlensiepen F, Grahammer M, Stenzel R, Simon D, Kleyer A, Krönke G, Sharp C, Bendzuck G, Korinth M, Elling-Audersch C, Vuillerme N, Schett G, Pecher AC, Krusche M: TELERA-Asynchronous TELEmedicine for Patients With Rheumatoid Arthritis: Study Protocol for a Prospective, Multi-Center, Randomized Controlled Trial. Front Med (Lausanne). 2021;8():
Regensburger AP, Brown E, Krönke G, Waldner MJ, Knieling F: Optoacoustic Imaging in Inflammation. Biomedicines. 2021;9(5):
Knab K, Chambers D, Krönke G: [Protective macrophages : New insights into the role of synovial macrophages in inflammatory joint diseases]. Z Rheumatol. 2021;80(10): 966-971
Mougiakakos D, Kroenke G, Schett G: More on CD19-CAR T Cells in Systemic Lupus Erythematosus N Engl J Med. 2021;385(19):
Tascilar K, Simon D, Kroenke G, Kleyer A, Ramming A, Atreya R, Tenbusch M, Ueberla K, Berking C, Sticherling M, Neurath MF, Schett G: PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES ARE OVERREPRESENTED IN LOW-FREQUENCY VIRAL SYMPTOM CLUSTERS Ann Rheum Dis. 2021;80 Suppl 1(): 996-997
Folle L, Liu C, Simon D, Meinderink T, Liphardt AM, Kroenke G, Schett G, Maier A, Kleyer A: DIFFERENTIAL DIAGNOSIS OF RA AND PSA USING NEURAL NETWORKS ON THREE-DIMENSIONAL BONE SHAPE OF FINGER JOINTS Ann Rheum Dis. 2021;80 Suppl 1(): 86-87
Tascilar K, Simon D, Liphardt AM, Meinderink T, Bayat S, Rech J, Hueber A, Kroenke G, Schett G, Kleyer A: SPATIOTEMPORAL DYNAMICS OF BONE LOSS BEFORE AND AFTER THE ONSET OF RHEUMATOID ARTHRITIS Ann Rheum Dis. 2021;80 Suppl 1(): 88-89
Pfeifle R, Kittler J, Wuhrer M, Schett G, Kroenke G: THE IMPACT OF IL-17A THERAPY ON IGG SIALYLATION IN HUMANS Ann Rheum Dis. 2021;80 Suppl 1(): 1042-1043
Schneidereit D, Bröllochs A, Ritter P, Kreiß L, Mokhtari Z, Beilhack A, Krönke G, Ackermann JA, Faas M, Grüneboom A, Schürmann S, Friedrich O: An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle. Theranostics. 2021;11(6): 2876-2891
Taubmann J, Krishnacoumar B, Böhm C, Faas M, Müller DIH, Adam S, Stoll C, Böttcher M, Mougiakakos D, Sonnewald U, Hofmann J, Schett G, Krönke G, Scholtysek C: Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis. Sci Rep. 2020;10(1):
Simon D, Tascilar K, Kronke G, Kleyer A, Zaiss M, Heppt F, Meder C, Atreya R, Klenske E, Dietrich P, Abdullah A, Kliem T, Corte G, Morf H, Leppkes M, Kremer A, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Maier C, Hueber A, Manger K, Manger B, Berking C, Tenbusch M, Ueberla K, Sticherling M, Neurath M, Schett G: Patients Receiving Cytokine Inhibitors Have Low Prevalence of SARS-CoV-2 Infection Arthritis Rheumatol. 2020;72 Suppl 10():
Müller DIH, Stoll C, Palumbo-Zerr K, Böhm C, Krishnacoumar B, Ipseiz N, Taubmann J, Zimmermann M, Böttcher M, Mougiakakos D, Tuckermann J, Djouad F, Schett G, Scholtysek C, Krönke G: PPARδ-mediated mitochondrial rewiring of osteoblasts determines bone mass. Sci Rep. 2020;10(1):
Hofheinz K, Seibert F, Ackermann JA, Dietel B, Tauchi M, Oszvar-Kozma M, Kühn H, Schett G, Binder CJ, Krönke G: Formation of atherosclerotic lesions is independent of eosinophils in male mice. Atherosclerosis. 2020;311(): 67-72
Andreev D, Liu M, Weidner D, Kachler K, Faas M, Grüneboom A, Schlötzer-Schrehardt U, Muñoz LE, Steffen U, Grötsch B, Killy B, Krönke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A: Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest. 2020;130(9): 4811-4830
Süß P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki JCM: Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep. 2020;30(12): 4082-4095.e6
Simon D, Tascilar K, Krönke G, Kleyer A, Zaiss MM, Heppt F, Meder C, Atreya R, Klenske E, Dietrich P, Abdullah A, Kliem T, Corte G, Morf H, Leppkes M, Kremer AE, Ramming A, Pachowsky M, Schuch F, Ronneberger M, Kleinert S, Maier C, Hueber AJ, Manger K, Manger B, Berking C, Tenbusch M, Überla K, Sticherling M, Neurath MF, Schett G: Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion. Nat Commun. 2020;11(1):
Tajik N, Frech M, Schulz O, Schälter F, Lucas S, Azizov V, Dürholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krönke G, Luo Y, Überla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Cañete JD, Ciccia F, Schett G, Zaiss MM: Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun. 2020;11(1):
Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ: JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. Sci Transl Med. 2020;12(530):
Renner N, Kleyer A, Krönke G, Simon D, Söllner S, Rech J, Uder M, Janka R, Schett G, Welsch GH, Pachowsky ML: T2 Mapping as a New Method for Quantitative Assessment of Cartilage Damage in Rheumatoid Arthritis. J Rheumatol. 2020;47(6): 820-825
Contreras-Lopez RA, Elizondo-Vega R, Torres MJ, Vega-Letter AM, Luque-Campos N, Paredes-Martinez MJ, Pradenas C, Tejedor G, Oyarce K, Salgado M, Jorgensen C, Khoury M, Kronke G, Garcia-Robles MA, Altamirano C, Luz-Crawford P, Djouad F: PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties. Sci Rep. 2020;10(1):
Hueber AJ, Krönke G: Identifying 'non-progressors' among patients with arthralgia. Nat Rev Rheumatol. 2020;16(5): 251-252
Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brueggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Kroenke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blueml S, Schabbauer G: Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun. 2020;11(1):
Simader E, Puchner A, Saferding V, Goncalves-Alves E, Pfeifle R, Kroenke G, Smolen J, Blueml S: IMPORTANT ROLE OF DENDRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2019;78(): A54-A55
Adam S, Simon N, Steffen U, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITION BY BARICITINIB AND TOFACITINIB AMELIORATES PATHOLOGICAL BONE LOSS Ann Rheum Dis. 2019;78(): A65-A65
Grüneboom A, Hawwari I, Weidner D, Culemann S, Müller S, Henneberg S, Brenzel A, Merz S, Bornemann L, Zec K, Wuelling M, Kling L, Hasenberg M, Voortmann S, Lang S, Baum W, Ohs A, Kraff O, Quick HH, Jäger M, Landgraeber S, Dudda M, Danuser R, Stein JV, Rohde M, Gelse K, Garbe AI, Adamczyk A, Westendorf AM, Hoffmann D, Christiansen S, Engel DR, Vortkamp A, Krönke G, Herrmann M, Kamradt T, Schett G, Hasenberg A, Gunzer M: A network of trans-cortical capillaries as mainstay for blood circulation in long bones. Nat Metab. 2019;1(2): 236-250
Gelse K, Biggemann J, Stumpf M, Halmheu M, Grüneboom A, Kleyer A, Scholtysek C, Pachowsky ML, Hueber A, Krönke G, Fey T: Modular Lattice Constructs for Biological Joint Resurfacing. Tissue Eng Part A. 2019;25(13-14): 1053-1062
Kleyer A, Simon D, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Kroenke G, Schett G: MICRO-STRUCTURAL CHANGES ASSOCIATED WITH ANTI-CITRULLINATED VIMENTIN AUTOIMMUNITY IN RA-AT-RISK INDIVIDUALS PRECIPITATE THE ONSET OF RHEUMATOID ARTHRITIS Ann Rheum Dis. 2019;78(): 133-133
Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Kroenke G, Voehringer D: RELM alpha-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection Sci Immunol. 2019;4(35):
O'Donnell VB, Aldrovandi M, Murphy RC, Kroenke G: Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death Sci Signal. 2019;12(574):
Schett G, Simon D, Hueber A, Bang H, Rech J, Kroenke G, Kleyer A: Anti-citrullinated Vimentin Antibodies Are Associated to Early Deterioration of Cortical Bone and Volumetric Bone Mineral Density in Finger Joints in RA-at-risk Patients Arthritis Rheumatol. 2019;71():
Puchner A, Simader E, Saferding V, Kroenke G, Pfeifle R, Aletaha D, Smolen J, Blueml S: Important Role of CD11c(+) Cells in Inflammatory Arthritis Arthritis Rheumatol. 2019;71():
Culemann S, Grueneboom A, Angel Nicolas-Avila JA, Weidner D, Laemmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Baeuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Kroenke G: Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572(7771): 670-675
Culemann S, Grueneboom A, Kroenke G: Origin and function of synovial macrophage subsets during inflammatory joint disease Adv Immunol. 2019;143(): 75-98
Adam S, Simon N, Steffen U, Harre N, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITORS TOFACITINIB AND BARICITINIB IMPROVE PATHOLOGICAL BONE LOSS IN VIVO Ann Rheum Dis. 2019;78(): 110-110
Puchner A, Simader E, Saferding V, Kroenke G, Pfeifle R, Aletaha D, Smolen JS, Blueml S: IMPORTANT ROLE OF CD11C+CELLSIN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2019;78(): 1094-1094
Wissbrock A, Goradia NB, Kumar A, George AAP, Kuehl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Kroenke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschlaeger O, Imhof D: Structural insights into heme binding to IL-36 alpha proinflammatory cytokine Sci Rep. 2019;9():
Pfeifle R, Kittler J, Rothe T, Schett G, Kroenke G: THE ROLE OF THE IL-23/TH17 AXIS AS MODULATOR OF B CELL-MEDIATED (AUTO)IMMUNE RESPONSES Ann Rheum Dis. 2019;78(): A42-A42
Allen-Redpath K, Aldrovandi M, Lauder SN, Gketsopoulou A, Tyrrell VJ, Slatter DA, Andrews R, Watkins WJ, Atkinson G, McNeill E, Gilfedder A, Protty M, Burston J, Johnson SRC, Rodrigues PRS, Jones DO, Lee R, Handa A, Channon K, Obaji S, Alvarez-Jarreta J, Kronke G, Ackermann J, Jenkins PV, Collins PW, O'Donnell VB: Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity Proc Natl Acad Sci U S A. 2019;116(16): 8038-8047
Kroenke G: REGULATION OF AUTOANTIBODY ACTIVITY BY T CELL SUBSETS Ann Rheum Dis. 2019;78(): 30-30
Puchner A, Saferding V, Pfeifle R, Kroenke G, Redlich K, Smolen J, Blueml S: IMPORTANT ROLE OF CD11C+DENDRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2018;77(): A36-A37
Puchner A, Saferding V, Bonelli M, Leiss H, Pfeifle R, Kroenke G, Smolen J, Redlich K, Blueml S: CD11C+DENDTRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2018;77(): 256-256
Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d'Elia H, Schett G: Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis Res Ther. 2018;20(1):
Biermann MHC, Boeltz S, Pieterse E, Knopf J, Rech J, Bilyy R, van der Vlag J, Tincani A, Distler JHW, Kroenke G, Schett GA, Herrmann M, Munoz LE: Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus Front Immunol. 2018;9():
Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM: The B cell response to citrullinated antigens in the development of rheumatoid arthritis. Nat Rev Rheumatol. 2018;14(3): 157-169
Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A: [Mutual influence of immune system and bones]. Z Rheumatol. 2018;77(Suppl 1): 8-11
Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM: Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24(1): 169-180
Haberland K, Ackermann JA, Ipseiz N, Culemann S, Pracht K, Englbrecht M, Jäck HM, Schett G, Schuh W, Krönke G: Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow. Eur J Immunol. 2018;48(5): 822-828
Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G: NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover. J Bone Miner Res. 2018;33(11): 2035-2047
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2018;215(3):
Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G: The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis. J Cell Mol Med. 2018;22(9): 4399-4409
Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP: Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis. Ann Rheum Dis. 2018;77(11): 1610-1618
Renner N, Kleyer A, Kroenke G, Simon D, Rech J, Schett G, Welsch G, Pachowsky ML: CARTILAGE DAMAGE QUANTITATIVELY ASSESSED BY MRI USING T2 MAPPING IN CCP-POSITIVE RA PATIENTS Ann Rheum Dis. 2018;77(): 1181-1181
Rauner M, Buttgereit F, Distler J, Garbe AI, Herrmann M, Hofbauer L, Hoffmann M, Jessberger R, Kornak U, Krönke G, Mundlos S, Spies C, Tuckermann J, Zwerina J: [Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation]. Z Rheumatol. 2018;77(Suppl 1): 12-15
Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM: Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018;9(1): 55
Ackermann JA, Hofheinz K, Zaiss MM, Krönke G: The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(4): 371-381
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol. 2017;18(1): 104-113
Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G: Corrigendum to "Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis" [Osteoarthritis Cartilage 23 (2015) 1221-1225]. Osteoarthritis Cartilage. 2017;25(6): 995
Djouad F, Ipseiz N, Luz-Crawford P, Scholtysek C, Krönke G, Jorgensen C: PPAR?/?: A master regulator of mesenchymal stem cell functions. Biochimie. 2017;136(): 55-58
Kleyer A, Beyer L, Simon C, Stemmler F, Englbrecht M, Beyer C, Rech J, Manger B, Krönke G, Schett G, Hueber AJ: Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage. Arthritis Res Ther. 2017;19(1): 34

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Prof. Dr. G. Krönke

Publications: Prof. Dr. med. G. Krönke

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