Medizin 3

Publications: Prof. Dr. med. G. Krönke

Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brueggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Kroenke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blueml S, Schabbauer G: Environmental arginine controls multinuclear giant cell metabolism and formation Nat Commun. 2020;11(1):
Adam S, Simon N, Steffen U, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITION BY BARICITINIB AND TOFACITINIB AMELIORATES PATHOLOGICAL BONE LOSS Ann Rheum Dis. 2019;78(): A65-A65
Adam S, Simon N, Steffen U, Harre N, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITORS TOFACITINIB AND BARICITINIB IMPROVE PATHOLOGICAL BONE LOSS IN VIVO Ann Rheum Dis. 2019;78(): 110-110
Pfeifle R, Kittler J, Rothe T, Schett G, Kroenke G: THE ROLE OF THE IL-23/TH17 AXIS AS MODULATOR OF B CELL-MEDIATED (AUTO)IMMUNE RESPONSES Ann Rheum Dis. 2019;78(): A42-A42
Allen-Redpath K, Aldrovandi M, Lauder SN, Gketsopoulou A, Tyrrell VJ, Slatter DA, Andrews R, Watkins WJ, Atkinson G, McNeill E, Gilfedder A, Protty M, Burston J, Johnson SRC, Rodrigues PRS, Jones DO, Lee R, Handa A, Channon K, Obaji S, Alvarez-Jarreta J, Kronke G, Ackermann J, Jenkins PV, Collins PW, O'Donnell VB: Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity Proc Natl Acad Sci U S A. 2019;116(16): 8038-8047
Kleyer A, Simon D, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Kroenke G, Schett G: MICRO-STRUCTURAL CHANGES ASSOCIATED WITH ANTI-CITRULLINATED VIMENTIN AUTOIMMUNITY IN RA-AT-RISK INDIVIDUALS PRECIPITATE THE ONSET OF RHEUMATOID ARTHRITIS Ann Rheum Dis. 2019;78(): 133-133
Culemann S, Grueneboom A, Angel Nicolas-Avila JA, Weidner D, Laemmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Baeuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Kroenke G: Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature. 2019;572(7771): 670-675
Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Kroenke G, Voehringer D: RELM alpha-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection Sci Immunol. 2019;4(35):
Culemann S, Grueneboom A, Kroenke G: Origin and function of synovial macrophage subsets during inflammatory joint disease Adv Immunol. 2019;143(): 75-98
O'Donnell VB, Aldrovandi M, Murphy RC, Kroenke G: Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death Sci Signal. 2019;12(574):
Puchner A, Simader E, Saferding V, Kroenke G, Pfeifle R, Aletaha D, Smolen JS, Blueml S: IMPORTANT ROLE OF CD11C+CELLSIN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2019;78(): 1094-1094
Kroenke G: REGULATION OF AUTOANTIBODY ACTIVITY BY T CELL SUBSETS Ann Rheum Dis. 2019;78(): 30-30
Schett G, Simon D, Hueber A, Bang H, Rech J, Kroenke G, Kleyer A: Anti-citrullinated Vimentin Antibodies Are Associated to Early Deterioration of Cortical Bone and Volumetric Bone Mineral Density in Finger Joints in RA-at-risk Patients Arthritis Rheumatol. 2019;71():
Wissbrock A, Goradia NB, Kumar A, George AAP, Kuehl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Kroenke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschlaeger O, Imhof D: Structural insights into heme binding to IL-36 alpha proinflammatory cytokine Sci Rep. 2019;9():
Simader E, Puchner A, Saferding V, Goncalves-Alves E, Pfeifle R, Kroenke G, Smolen J, Blueml S: IMPORTANT ROLE OF DENDRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2019;78(): A54-A55
Puchner A, Simader E, Saferding V, Kroenke G, Pfeifle R, Aletaha D, Smolen J, Blueml S: Important Role of CD11c(+) Cells in Inflammatory Arthritis Arthritis Rheumatol. 2019;71():
Renner N, Kleyer A, Kroenke G, Simon D, Rech J, Schett G, Welsch G, Pachowsky ML: CARTILAGE DAMAGE QUANTITATIVELY ASSESSED BY MRI USING T2 MAPPING IN CCP-POSITIVE RA PATIENTS Ann Rheum Dis. 2018;77(): 1181-1181
Scholtysek C, Ipseiz N, Böhm C, Krishnacoumar B, Stenzel M, Czerwinski T, Palumbo-Zerr K, Rothe T, Weidner D, Klej A, Stoll C, Distler J, Tuckermann J, Herrmann M, Fabry B, Goldmann WH, Schett G, Krönke G: NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover. J Bone Miner Res. 2018;33(11): 2035-2047
Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM: Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018;9(1): 55
Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM: Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24(1): 169-180
Rauner M, Buttgereit F, Distler J, Garbe AI, Herrmann M, Hofbauer L, Hoffmann M, Jessberger R, Kornak U, Krönke G, Mundlos S, Spies C, Tuckermann J, Zwerina J: [Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation]. Z Rheumatol. 2018;77(Suppl 1): 12-15
Haberland K, Ackermann JA, Ipseiz N, Culemann S, Pracht K, Englbrecht M, Jäck HM, Schett G, Schuh W, Krönke G: Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow. Eur J Immunol. 2018;48(5): 822-828
Fischer A, Abdollahi-Roodsaz S, Böhm C, Niederreiter B, Meyer B, Yau ACY, Lönnblom E, Joosten LAB, Koenders M, Lehmann CHK, Dudziak D, Krönke G, Holmdahl R, Steiner G: The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis. J Cell Mol Med. 2018;22(9): 4399-4409
Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A: [Mutual influence of immune system and bones]. Z Rheumatol. 2018;77(Suppl 1): 8-11
Koenen M, Culemann S, Vettorazzi S, Caratti G, Frappart L, Baum W, Krönke G, Baschant U, Tuckermann JP: Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis. Ann Rheum Dis. 2018;77(11): 1610-1618
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2018;215(3):
Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d'Elia H, Schett G: Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis Res Ther. 2018;20(1):
Puchner A, Saferding V, Bonelli M, Leiss H, Pfeifle R, Kroenke G, Smolen J, Redlich K, Blueml S: CD11C+DENDTRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2018;77(): 256-256
Puchner A, Saferding V, Pfeifle R, Kroenke G, Redlich K, Smolen J, Blueml S: IMPORTANT ROLE OF CD11C+DENDRITIC CELLS IN INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2018;77(): A36-A37
Biermann MHC, Boeltz S, Pieterse E, Knopf J, Rech J, Bilyy R, van der Vlag J, Tincani A, Distler JHW, Kroenke G, Schett GA, Herrmann M, Munoz LE: Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus Front Immunol. 2018;9():
Scherer HU, Huizinga TWJ, Krönke G, Schett G, Toes REM: The B cell response to citrullinated antigens in the development of rheumatoid arthritis. Nat Rev Rheumatol. 2018;14(3): 157-169
Djouad F, Ipseiz N, Luz-Crawford P, Scholtysek C, Krönke G, Jorgensen C: PPAR?/?: A master regulator of mesenchymal stem cell functions. Biochimie. 2017;136(): 55-58
Fischer A, Boehm C, Koenders M, van den Berg W, Rothe T, Kroenke G, Dudziak D, Steiner G: IMPACT OF TOLL-LIKE RECEPTOR 9 IN INFLAMMATORY ARTHRITIS AND OSTEOCLASTOGENESIS Ann Rheum Dis. 2017;76(): A86-A86
Kronke G: DIFFERENTIAL SCAVENGING OF APOPTOTIC CELLS AND BACTERIA Ann Rheum Dis. 2017;76(): 15-15
Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB: Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Sci Signal. 2017;10(507):
Bonyadi Rad E, Musumeci G, Pichler K, Heidary M, Szychlinska MA, Castrogiovanni P, Marth E, Böhm C, Srinivasaiah S, Krönke G, Weinberg A, Schäfer U: Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes. Sci Rep. 2017;7(1): 17947
Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes IB, Wirtz S, Gaipl US, Krönke G, Schett G, Frey S, Hueber AJ: Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction. Front Immunol. 2017;8(): 722
Lucas S, Omata Y, Boettcher M, Hofmann J, Krishnacoumar B, Kroenke G, Mougiakakos D, Iljazovic A, Sonnewald U, Strowig T, Schett G, Zaiss M: Short chain fatty acids are potent regulators of systemic bone mass and protect for pathological bone loss by inhibiting osteoclasts Eur J Immunol. 2017;47(): 217-217
Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G: The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation. J Immunol. 2017;198(10): 3878-3885
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2017;214(7): 2121-2138
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol. 2017;18(1): 104-113
Ackermann JA, Hofheinz K, Zaiss MM, Krönke G: The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(4): 371-381
Engdahl C, Raufer J, Harre U, Bondt A, Pfeifle R, Kroenke G, Scherer HU, Forsblad H, Schett G: ESTROGEN INFLUENCES THE SIALYLATION PROFILE AND INFLAMMATORY PROPERTIES OF ANTIBODIES - A POTENTIAL EXPLANATION FOR THE SEX DIFFERENCES AND INCREASED RISK FOR RA IN POSTMENOPAUSAL WOMEN Ann Rheum Dis. 2017;76(): 775-775
Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G: Corrigendum to "Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis" [Osteoarthritis Cartilage 23 (2015) 1221-1225]. Osteoarthritis Cartilage. 2017;25(6): 995
Pfeifle R, Rothe T, Ipseiz N, Culemann S, Harre U, Schett G, Kroenke G: Novel mechanism mediated by the IL23/Th17 axis contributing to auto-immune arthritis Eur J Immunol. 2017;47(): 141-141
Renner N, Kleyer A, Simon D, Kroenke G, Rech J, Schett G, Welsch G, Pachowsky ML: Increased Cartilage Damage in Metacarpophalangeal Joints of ACPA Positive Rheumatoid Arthritis (RA) Patients Using T2 Mapping in 3 Tesla Magnetresonance Imaging (MRI) Arthritis Rheumatol. 2017;69():
Kleyer A, Beyer L, Simon C, Stemmler F, Englbrecht M, Beyer C, Rech J, Manger B, Krönke G, Schett G, Hueber AJ: Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage. Arthritis Res Ther. 2017;19(1): 34
Puchner A, Saferding V, Bonelli M, Leiss H, Kroenke G, Pfeifle R, Smolen JS, Redlich K, Blueml S: Important Role of CD11c+Dendtritic Cells in Inflammatory Arthritis Arthritis Rheumatol. 2017;69():
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Hueber AJ, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: NOVEL MECHANISM MEDIATED BY THE IL23/TH17 AXIS CONTRIBUTING TO AUTO-IMMUNE ARTHRITIS Ann Rheum Dis. 2017;76 1(): A6-A7
Luz-Crawford P, Ipseiz N, Espinosa-Carrasco G, Caicedo A, Tejedor G, Toupet K, Loriau J, Scholtysek C, Stoll C, Khoury M, Noël D, Jorgensen C, Krönke G, Djouad F: PPAR?/? directs the therapeutic potential of mesenchymal stem cells in arthritis. Ann Rheum Dis. 2016;75(12): 2166-2174
Stein K, Stoffels M, Lysson M, Schneiker B, Dewald O, Krönke G, Kalff JC, Wehner S: A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. J Leukoc Biol. 2016;99(2): 231-9
Pfeifle R, Rothe T, Ipseiz N, Culemann S, Harre U, Kroenke G, Schett G: Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis Arthritis Rheumatol. 2016;68():
Kleyer A, Beyer L, Simon C, Stemmler F, Rech J, Englbrecht M, Manger B, Kroenke G, Schett G, Hueber AJ: From 3D Printed Bones to Arthritis Patients - Arthro-Haptic Experience Supporting Disease Awareness Arthritis Rheumatol. 2016;68():
Pfeifle R, Rothe T, Scherer HU, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: IL-17/23 IN THE TRANSITION FROM AUTOIMMUNITY TO INFLAMMATION Clin Exp Rheumatol. 2016;34(4): 726-726
Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G: Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis. Osteoarthritis Cartilage. 2015;23(7): 1221-5
Sahin E, Brunner JS, Kral JB, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal AM, Krönke G, Blüml S, Schabbauer G: Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol. 2015;195(6): 2560-70
Harre U, Lang SC, Pfeifle R, Rombouts Y, Frühbeißer S, Amara K, Bang H, Lux A, Koeleman CA, Baum W, Dietel K, Gröhn F, Malmström V, Klareskog L, Krönke G, Kocijan R, Nimmerjahn F, Toes RE, Herrmann M, Scherer HU, Schett G: Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun. 2015;6(): 6651
Krönke G: Regulated sorting of self and non-self by macrophage subsets Eur J Clin Invest. 2015;45 2(): 50-50
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH: Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Ann Rheum Dis. 2015;74(6): 1317-24
Puchner A, Saferding V, Goncalves-Alves E, Krönke G, Pfeifle R, Hayer S, Smolen JS, Redlich K, Blüml S: Important Role of CD11c+Dendritic Cells in Inflammatory Arthritis Arthritis Rheumatol. 2015;67 10(): -
Hahn J, Kienhofer D, Munoz L, Herrmann M, Krönke G, Holmdahl R, Schett G, Hoffmann M: The Oxidative Burst Mediates Anti-Inflammatory Clearance of Dead Cells in a Mouse Model of SLE and Inflammatory Arthritis Arthritis Rheumatol. 2015;67 10(): -
Hahn J, Kienhofer D, Munoz LE, Holmdahl R, Krönke G, Schett G, Herrmann M, Hoffmann MH: The oxidative burst mediates anti-inflammatory clearance of dead cells in a mouse model of Systemic lupus Erythematosus (SLE) and inflammatory arthritis Clin Exp Rheumatol. 2015;33 90(3): S9-S9
Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH: Orphan nuclear receptor NR4A1 regulates transforming growth factor-? signaling and fibrosis. Nat Med. 2015;21(2): 150-8
Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A: Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab. 2015;22(5): 886-94
Rothe T, Gruber F, Uderhardt S, Ipseiz N, Rössner S, Oskolkova O, Blüml S, Leitinger N, Bicker W, Bochkov VN, Yamamoto M, Steinkasserer A, Schett G, Zinser E, Krönke G: 12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function. J Clin Invest. 2015;125(5): 1944-54
Kleyer A, Hueber AJ, Rech J, Stemmler F, Kroenke G, Simon D, Schett G: INTRODUCTION OF 3D PRINTING INTO RHEUMATOLOGY-TRANSFERRING IMAGES FROM ARTHRITIC JOINTS INTO MODELS Ann Rheum Dis. 2014;73 2(): 464-464
Scholtysek C, Ipseiz N, Djouad F, Schett G, Krönke G: OSTEOBLAST-SPECIFIC EXPRESSION OF THE NUCLEAR RECEPTOR PPAR-DELTA CONTROLS BONE AND GLUCOSE HOMEOSTASIS Ann Rheum Dis. 2014;73 2(): 792-792
Baschant U, Koenen M, Culemann S, Schauer S, Ahmad M, Wittig-Blaich S, Knoll J, Kroll T, Krönke G, Dudeck A, Rauner M, Seibel M, Ploubidou A, Hofbauer L, Zhou H, Tuckermann J: Novel Mechanisms of the glucocorticoid receptor in inflammatory bone disease and bone loss Exp Clin Endocrinol Diabetes. 2014;122(3): -
Fischer A, Böhm C, Saferding V, Goncalves-Alves E, Kreindl R, Koenders M, van den Berg W, Rothe T, Krönke G, Dudziak D, Steiner G: ROLE OF TOLL-LIKE RECEPTOR 9 IN THE PATHOGENESIS OF INFLAMMATORY AUTOIMMUNE ARTHRITIS AND OSTEOCLAST ACTIVATION Ann Rheum Dis. 2014;73 2(): 840-840
Ipseiz N, Scholtysek C, Culemann S, Krönke G: Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis. Swiss Med Wkly. 2014;144(): w14055
Beyer C, Beer J, Palumbo-Zer K, Zerr P, Distler A, Dees C, Munoz L, Kroenke G, Uderhardt S, Distler O, Ovarecz T, Schett G, Distler J: ACTIVATION OF LIVER X RECEPTORS INHIBITS EXPERIMENTAL FIBROSIS BY INTERFERING WITH INTERLEUKIN-6 RELEASE FROM MACROPHAGES Clin Exp Rheumatol. 2014;32 81(2): S65-S65
Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R: Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature. Antioxid Redox Signal. 2014;21(16): 2231-45
Ipseiz N, Uderhardt S, Scholtysek C, Steffen M, Schabbauer G, Bozec A, Schett G, Krönke G: The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells. J Immunol. 2014;192(10): 4852-8
Renner N, Krönke G, Rech J, Uder M, Janka R, Lauer L, Paul D, Herz B, Schlechtweg P, Hennig FF, Schett G, Welsch G: Anti-citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints. Arthritis Rheumatol. 2014;66(12): 3283-8
Rothe T, Oskolkova O, Steinkasserer A, Bochkov VN, Schett G, Zinser E, Krönke G: ENZYMATIC LIPID OXIDATION BY 12/15-LIPOXYGENASE REGULATES MATURATION AND FUNCTION OF DENDRITIC CELLS Ann Rheum Dis. 2014;73 1(): A82-A82
Baschant U, Culemann S, Dudeck A, Krönke G, Tuckermann J: Novel mechanisms of glucocorticoid therapy in arthritis Z Rheumatol. 2013;72 2(): 48-48
Harre U, Pfeifle R, Lux A, Fruhbeisser S, Grohn F, Krönke G, Nimmerjahn F, Herrmann M, Schett G: Fc-GLYCOSYLATION DETERMINES OSTEOCLASTOGENIC ACTIVITY OF IMMUNE COMPLEXES Ann Rheum Dis. 2013;72 1(): A58-A58
Tomcik M, Böhm C, Scholtysek C, Cerezo LA, Baum W, Dees C, Beyer C, Avouac J, Zerr P, Palumbo-Zerr K, Distler A, Becvar R, Distler O, Grigorian M, Krönke G, Schett G, Distler JH, Senolt L: THE LOSS OF S100A4 PREVENTS JOINT DESTRUCTION AND SYSTEMIC BONE LOSS IN HTNFTG MOUSE MODEL Ann Rheum Dis. 2013;72 3(): 201-201
Beyer C, Beer J, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Munoz LE, Krönke G, Distler O, Anderson S, Schett GA, Distler JHW: Activation Of Liver X Receptors Inhibits Experimental Fibrosis By Interfering With Interleukin-6 Release From Macrophages. Arthritis Rheum. 2013;65 10(): S350-S350
Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G, Distler JH: Autophagy regulates TNF?-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 2013;72(5): 761-8
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M: Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids. Cell Death Differ. 2013;20(9): 1230-40
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G: PPAR?/? governs Wnt signaling and bone turnover. Nat Med. 2013;19(5): 608-13
Pfeifle R, Magorivska I, Scherer U, Harre U, Rothe T, Bohm S, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: IL23/TH17-MEDIATED REGULATION OF ANTIBODY GLYCOSYLATION CONTROLS AUTOIMUNE-INDUCED ARTHRITIS Ann Rheum Dis. 2013;72 1(): A13-A13
Uderhardt S, Herrmann M, Oskolkova O, Aschermann S, Bicker W, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Krönke G: 12/15-LIPOXYGENASE ORCHESTRATES THE CLEARANCE OF APOPTOTIC CELLS AND MAINTAINS IMMUNOLOGIC TOLERANCE Ann Rheum Dis. 2012;71 1(): S2
Uderhardt S, Herrmann M, Oskolkova OV, Aschermann S, Bicker W, Ipseiz N, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Krönke G: 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity. 2012;36(5): 834-46
Rothe T, Zinser E, Rössner S, Uderhardt S, Bochkov V, Oskolkova O, Schett G, Steinkasserer A, Krönke G: 12/15-lipoxygenase-mediated lipid oxidation regulates maturation of dendritic cells Immunology. 2012;137 1(): 465-465
Uderhardt S, Rothe T, Zinser E, Oskolkova O, Herrmann M, Steinkasserer A, Bochkov V, Schett G, Krönke G: Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function. Arthritis Rheum. 2012;64 S(10): S462-S462
Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G: Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res. 2012;27(12): 2442-51
Taylor PR, Heydeck D, Jones GW, Krönke G, Funk CD, Knapper S, Adams D, Kuhn H, O'Donnell VB: Development of myeloproliferative disease in 12/15-lipoxygenase deficiency. Blood. 2012;119(25): 6173-4; author reply 6174
Scholtysek C, Krönke G, Schett G: Inflammation-associated changes in bone homeostasis. Inflamm Allergy Drug Targets. 2012;11(3): 188-95
Krönke G, Reich N, Scholtysek C, Akhmetshina A, Uderhardt S, Zerr P, Palumbo K, Lang V, Dees C, Distler O, Schett G, Distler JH: The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. Ann Rheum Dis. 2012;71(6): 1081-7
Schwab I, Biburger M, Krönke G, Schett G, Nimmerjahn F: IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol. 2012;42(4): 826-30
Uderhardt S, Krönke G: 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J Mol Med. 2012;90(11): 1247-56
Dees C, Akhmetshina A, Zerr P, Reich N, Palumbo K, Horn A, Jüngel A, Beyer C, Krönke G, Zwerina J, Reiter R, Alenina N, Maroteaux L, Gay S, Schett G, Distler O, Distler JH: Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med. 2011;208(5): 961-72
Uderhardt Stefan, Herrmann Martin, Oskolikova Olga, Aschermann Susanne, Frey Benjamin, Voll Reinhard, Nimmerjahn Falk, Bochkov ValeryN, Schett Georg, Kroenke Gerhard: 12/15-LIPOXYGENASE ORCHESTRATES THE CLEARANCE OF APOPTOTIC CELLS AND MAINTAINS IMMUNOLOGICAL TOLERANCE Ann Rheum Dis. 2011;70 2(): -
Scholtysek C, Uderhardt S, Schett G, Krönke G: NR4A1 MODULATES THE INFLAMMATORY RESPONSE DURING MURINE EXPERIMENTAL ARTHRITIS Ann Rheum Dis. 2010;69 Suppl. (): A91 -
Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, Krönke G, Schett G: Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis. 2010;69(3): 592-7
Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A: R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum. 2010;62(8): 2303-12
Stach CM, Bäuerle M, Englbrecht M, Krönke G, Engelke K, Manger B, Schett G: Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum. 2010;62(2): 330-9
Krönke G, Uderhardt S, Katzenbeisser J, Schett G: The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity. 2009;42(4): 383-5

Prof. Dr. G. Krönke

Medicine 3

Publications: Prof. Dr. med. G. Krönke