Publications: Prof. Dr. med. G. Krönke

Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM: Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018;9(1): 55
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Hueber AJ, Herrmann M, Bluml S, Nimmerjahn F, Schett G, Kronke G: NOVEL MECHANISM MEDIATED BY THE IL23/TH17 AXIS CONTRIBUTING TO AUTO-IMMUNE ARTHRITIS Ann Rheum Dis. 2017;76 1: A6-A7
Kleyer A, Beyer L, Simon C, Stemmler F, Englbrecht M, Beyer C, Rech J, Manger B, Krönke G, Schett G, Hueber AJ: Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage. Arthritis Res Ther. 2017;19(1): 34
Ackermann JA, Hofheinz K, Zaiss MM, Krönke G: The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim Biophys Acta. 2017;1862(4): 371-381
Djouad F, Ipseiz N, Luz-Crawford P, Scholtysek C, Krönke G, Jorgensen C: PPAR?/?: A master regulator of mesenchymal stem cell functions. Biochimie. 2017;136: 55-58
Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes IB, Wirtz S, Gaipl US, Krönke G, Schett G, Frey S, Hueber AJ: Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction. Front Immunol. 2017;8: 722
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2017;214(7): 2121-2138
Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G: The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation. J Immunol. 2017;198(10): 3878-3885
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol. 2017;18(1): 104-113
Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G: Corrigendum to "Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis" [Osteoarthritis Cartilage 23 (2015) 1221-1225]. Osteoarthritis Cartilage. 2017;25(6): 995
Bonyadi Rad E, Musumeci G, Pichler K, Heidary M, Szychlinska MA, Castrogiovanni P, Marth E, Böhm C, Srinivasaiah S, Krönke G, Weinberg A, Schäfer U: Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes. Sci Rep. 2017;7(1): 17947
Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB: Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Sci Signal. 2017;10(507)
Luz-Crawford P, Ipseiz N, Espinosa-Carrasco G, Caicedo A, Tejedor G, Toupet K, Loriau J, Scholtysek C, Stoll C, Khoury M, Noël D, Jorgensen C, Krönke G, Djouad F: PPAR?/? directs the therapeutic potential of mesenchymal stem cells in arthritis. Ann Rheum Dis. 2016;75(12): 2166-2174
Pfeifle R, Rothe T, Scherer HU, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Holmdahl R, Herrmann M, Bluml S, Nimmerjahn F, Schett G, Kronke G: IL-17/23 IN THE TRANSITION FROM AUTOIMMUNITY TO INFLAMMATION Clin Exp Rheumatol. 2016;34(4): 726-726
Stein K, Stoffels M, Lysson M, Schneiker B, Dewald O, Krönke G, Kalff JC, Wehner S: A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. J Leukoc Biol. 2016;99(2): 231-9
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH: Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Ann Rheum Dis. 2015;74(6): 1317-24
Hahn J, Kienhofer D, Munoz L, Herrmann M, Kronke G, Holmdahl R, Schett G, Hoffmann M: The Oxidative Burst Mediates Anti-Inflammatory Clearance of Dead Cells in a Mouse Model of SLE and Inflammatory Arthritis Arthritis Rheumatol. 2015;67 10: -
Puchner A, Saferding V, Goncalves-Alves E, Kronke G, Pfeifle R, Hayer S, Smolen JS, Redlich K, Bluml S: Important Role of CD11c+Dendritic Cells in Inflammatory Arthritis Arthritis Rheumatol. 2015;67 10: -
Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A: Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab. 2015;22(5): 886-94
Hahn J, Kienhofer D, Munoz LE, Holmdahl R, Kronke G, Schett G, Herrmann M, Hoffmann MH: The oxidative burst mediates anti-inflammatory clearance of dead cells in a mouse model of Systemic lupus Erythematosus (SLE) and inflammatory arthritis Clin Exp Rheumatol. 2015;33 90(3): S9-S9
Kronke G: Regulated sorting of self and non-self by macrophage subsets Eur J Clin Invest. 2015;45 2: 50-50
Rothe T, Gruber F, Uderhardt S, Ipseiz N, Rössner S, Oskolkova O, Blüml S, Leitinger N, Bicker W, Bochkov VN, Yamamoto M, Steinkasserer A, Schett G, Zinser E, Krönke G: 12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function. J Clin Invest. 2015;125(5): 1944-54
Sahin E, Brunner JS, Kral JB, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal AM, Krönke G, Blüml S, Schabbauer G: Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol. 2015;195(6): 2560-70
Harre U, Lang SC, Pfeifle R, Rombouts Y, Frühbeißer S, Amara K, Bang H, Lux A, Koeleman CA, Baum W, Dietel K, Gröhn F, Malmström V, Klareskog L, Krönke G, Kocijan R, Nimmerjahn F, Toes RE, Herrmann M, Scherer HU, Schett G: Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun. 2015;6: 6651
Palumbo-Zerr K, Zerr P, Distler A, Fliehr J, Mancuso R, Huang J, Mielenz D, Tomcik M, Fürnrohr BG, Scholtysek C, Dees C, Beyer C, Krönke G, Metzger D, Distler O, Schett G, Distler JH: Orphan nuclear receptor NR4A1 regulates transforming growth factor-? signaling and fibrosis. Nat Med. 2015;21(2): 150-8
Stock M, Distler A, Distler J, Beyer C, Ruiz-Heiland G, Ipseiz N, Seeling M, Krönke G, Nimmerjahn F, Schett G: Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis. Osteoarthritis Cartilage. 2015;23(7): 1221-5
Rothe T, Oskolkova O, Steinkasserer A, Bochkov VN, Schett G, Zinser E, Kronke G: ENZYMATIC LIPID OXIDATION BY 12/15-LIPOXYGENASE REGULATES MATURATION AND FUNCTION OF DENDRITIC CELLS Ann Rheum Dis. 2014;73 1: A82-A82
Scholtysek C, Ipseiz N, Djouad F, Schett G, Kronke G: OSTEOBLAST-SPECIFIC EXPRESSION OF THE NUCLEAR RECEPTOR PPAR-DELTA CONTROLS BONE AND GLUCOSE HOMEOSTASIS Ann Rheum Dis. 2014;73 2: 792-792
Fischer A, Bohm C, Saferding V, Goncalves-Alves E, Kreindl R, Koenders M, van den Berg W, Rothe T, Kronke G, Dudziak D, Steiner G: ROLE OF TOLL-LIKE RECEPTOR 9 IN THE PATHOGENESIS OF INFLAMMATORY AUTOIMMUNE ARTHRITIS AND OSTEOCLAST ACTIVATION Ann Rheum Dis. 2014;73 2: 840-840
Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R: Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature. Antioxid Redox Signal. 2014;21(16): 2231-45
Renner N, Krönke G, Rech J, Uder M, Janka R, Lauer L, Paul D, Herz B, Schlechtweg P, Hennig FF, Schett G, Welsch G: Anti-citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints. Arthritis Rheumatol. 2014;66(12): 3283-8
Baschant U, Koenen M, Culemann S, Schauer S, Ahmad M, Wittig-Blaich S, Knoll J, Kroll T, Kronke G, Dudeck A, Rauner M, Seibel M, Ploubidou A, Hofbauer L, Zhou H, Tuckermann J: Novel Mechanisms of the glucocorticoid receptor in inflammatory bone disease and bone loss Exp Clin Endocrinol Diabetes. 2014;122(3): -
Ipseiz N, Uderhardt S, Scholtysek C, Steffen M, Schabbauer G, Bozec A, Schett G, Krönke G: The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells. J Immunol. 2014;192(10): 4852-8
Ipseiz N, Scholtysek C, Culemann S, Krönke G: Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis. Swiss Med Wkly. 2014;144: w14055
Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G, Distler JH: Autophagy regulates TNF?-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 2013;72(5): 761-8
Pfeifle R, Magorivska I, Scherer U, Harre U, Rothe T, Bohm S, Herrmann M, Bluml S, Nimmerjahn F, Schett G, Kronke G: IL23/TH17-MEDIATED REGULATION OF ANTIBODY GLYCOSYLATION CONTROLS AUTOIMUNE-INDUCED ARTHRITIS Ann Rheum Dis. 2013;72 1: A13-A13
Harre U, Pfeifle R, Lux A, Fruhbeisser S, Grohn F, Kronke G, Nimmerjahn F, Herrmann M, Schett G: Fc-GLYCOSYLATION DETERMINES OSTEOCLASTOGENIC ACTIVITY OF IMMUNE COMPLEXES Ann Rheum Dis. 2013;72 1: A58-A58
Tomcik M, Bohm C, Scholtysek C, Cerezo LA, Baum W, Dees C, Beyer C, Avouac J, Zerr P, Palumbo-Zerr K, Distler A, Becvar R, Distler O, Grigorian M, Kronke G, Schett G, Distler JH, Senolt L: THE LOSS OF S100A4 PREVENTS JOINT DESTRUCTION AND SYSTEMIC BONE LOSS IN HTNFTG MOUSE MODEL Ann Rheum Dis. 2013;72 3: 201-201
Beyer C, Beer J, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Munoz LE, Kronke G, Distler O, Anderson S, Schett GA, Distler JHW: Activation Of Liver X Receptors Inhibits Experimental Fibrosis By Interfering With Interleukin-6 Release From Macrophages. Arthritis Rheum. 2013;65 10: S350-S350
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M: Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids. Cell Death Differ. 2013;20(9): 1230-40
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G: PPAR?/? governs Wnt signaling and bone turnover. Nat Med. 2013;19(5): 608-13
Baschant U, Culemann S, Dudeck A, Kronke G, Tuckermann J: Novel mechanisms of glucocorticoid therapy in arthritis Z Rheumatol. 2013;72 2: 48-48
Krönke G, Reich N, Scholtysek C, Akhmetshina A, Uderhardt S, Zerr P, Palumbo K, Lang V, Dees C, Distler O, Schett G, Distler JH: The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. Ann Rheum Dis. 2012;71(6): 1081-7
Uderhardt S, Herrmann M, Oskolkova O, Aschermann S, Bicker W, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Kronke G: 12/15-LIPOXYGENASE ORCHESTRATES THE CLEARANCE OF APOPTOTIC CELLS AND MAINTAINS IMMUNOLOGIC TOLERANCE Ann Rheum Dis. 2012;71 1: S2
Uderhardt S, Rothe T, Zinser E, Oskolkova O, Herrmann M, Steinkasserer A, Bochkov V, Schett G, Kronke G: Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function. Arthritis Rheum. 2012;64 S(10): S462-S462
Taylor PR, Heydeck D, Jones GW, Krönke G, Funk CD, Knapper S, Adams D, Kühn H, O'Donnell VB: Development of myeloproliferative disease in 12/15-lipoxygenase deficiency. Blood. 2012;119(25): 6173-4; author reply 6174
Schwab I, Biburger M, Krönke G, Schett G, Nimmerjahn F: IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol. 2012;42(4): 826-30
Uderhardt S, Herrmann M, Oskolkova OV, Aschermann S, Bicker W, Ipseiz N, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Krönke G: 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity. 2012;36(5): 834-46
Rothe T, Zinser E, Rossner S, Uderhardt S, Bochkov V, Oskolkova O, Schett G, Steinkasserer A, Kronke G: 12/15-lipoxygenase-mediated lipid oxidation regulates maturation of dendritic cells Immunology. 2012;137 1: 465-465
Scholtysek C, Krönke G, Schett G: Inflammation-associated changes in bone homeostasis. Inflamm Allergy Drug Targets. 2012;11(3): 188-95
Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JH, Tuckermann JP, Schett G, Krönke G: Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss. J Bone Miner Res. 2012;27(12): 2442-51
Uderhardt S, Krönke G: 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J Mol Med. 2012;90(11): 1247-56
Dees C, Akhmetshina A, Zerr P, Reich N, Palumbo K, Horn A, Jüngel A, Beyer C, Krönke G, Zwerina J, Reiter R, Alenina N, Maroteaux L, Gay S, Schett G, Distler O, Distler JH: Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med. 2011;208(5): 961-72
Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, Kronke G, Schett G: Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis. 2010;69(3): 592-7
Scholtysek C, Uderhardt S, Schett G, Kronke G: NR4A1 MODULATES THE INFLAMMATORY RESPONSE DURING MURINE EXPERIMENTAL ARTHRITIS Ann Rheum Dis. 2010;69 Suppl. : A91 -
Stach CM, Bäuerle M, Englbrecht M, Kronke G, Engelke K, Manger B, Schett G: Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high-resolution computed tomography. Arthritis Rheum. 2010;62(2): 330-9
Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A: R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum. 2010;62(8): 2303-12
Schett G, Stolina M, Dwyer D, Zack D, Uderhardt S, Krönke G, Kostenuik P, Feige U: Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis. Arthritis Rheum. 2009;60(9): 2644-54
Axmann R, Böhm C, Krönke G, Zwerina J, Smolen J, Schett G: Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. Arthritis Rheum. 2009;60(9): 2747-56
Krönke G, Uderhardt S, Katzenbeisser J, Schett G: The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity. 2009;42(4): 383-5
Krönke G, Katzenbeisser J, Uderhardt S, Zaiss MM, Scholtysek C, Schabbauer G, Zarbock A, Koenders MI, Axmann R, Zwerina J, Baenckler HW, van den Berg W, Voll RE, Kühn H, Joosten LA, Schett G: 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol. 2009;183(5): 3383-9
Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K: Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009;183(7): 4715-22
Böhm C, Hayer S, Kilian A, Zaiss MM, Finger S, Hess A, Engelke K, Kollias G, Krönke G, Zwerina J, Schett G, David JP: The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol. 2009;183(9): 5938-47
Polzer K, Soleiman A, Baum W, Axmann R, Distler J, Redlich K, Kilian A, Krönke G, Schett G, Zwerina J: Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha. Ann Rheum Dis. 2008;67(5): 602-8
Kronke G, Baum W, Axmann R, Zwerina J, Schett G: 12/15-lipoxygenase limits inflammation and tissue damage in murine inflammatory arthritis Ann Rheum Dis. 2008;67 Suppl. : 078 -
Herman S, Kronke G, Muller R, Zwerina J, Redlich K, Schett G: Osteoclast-associated receptor (OSCAR) and its role in rheumatoid arthritis Ann Rheum Dis. 2008;67 Suppl. : 106 -
Herman S, Müller RB, Krönke G, Zwerina J, Redlich K, Hueber AJ, Gelse H, Neumann E, Müller-Ladner U, Schett G: Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. Arthritis Rheum. 2008;58(10): 3041-50
Kronke G, Uderhardt S, Zhao J, Ah-Kim K, Binnerts M, Katzenbeisser J, Schett G, Abo A: R-spondin 1 protects from bone loss in Htnf transgenic and ovariectomized mice Arthritis Rheum. 2008;58 Suppl. (9): S646-S646
Herman S, Krönke G, Schett G: Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends Mol Med. 2008;14(6): 245-53
Kronke G, Katzenbeisser J, Uderhardt S, Baum W, Axmann R, Zwerina J, Schett G: 12/15-lipoxygenase is involved in the limitation of inflammation and tissue damage in murine arthritis Wien Klin Wochenschr. 2008;120 Suppl.: 37-37
Herman S, Kronke G, Muller R, Zwerina J, Redlich K, Schett G: OSCAR, a key co-stimulation molecule for osteoclasts, is induced in patients with rheumatoid arthritis Wien Klin Wochenschr. 2008;120 Suppl.: 7-7
Zwerina J, Redlich K, Polzer K, Joosten L, Krönke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasser J, Scheinecker C, Smolen JS, van den Berg W, Schett G: TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci U S A. 2007;104(28): 11742-7

Prof. Dr. G. Krönke

Medicine 3

Publications: Prof. Dr. med. G. Krönke