Prof. Dr. A. Bozec

Publikationen: Prof. Dr. rer. nat. A. Bozec

Garantziotis P, Beretta L, Lindblom J, Moysidou GS, Nikolopoulos D, Grieshaber-Bouyer R, Hagen M, Bergmann C, Wirsching A, Bozec A, PRECISESADS Clinical Consortium , Schneider M, Barturen G, Bertsias G, Boumpas DT, Alarcón-Riquelme ME, Mackensen A, Schett G, Parodis I:Differential molecular signatures in response to CD19-CAR T cell therapy compared with conventional pharmacotherapy in systemic lupus erythematosus.Ann Rheum Dis. 2026;85(1): 153-163
Tur C, Eckstein M, Rauber S, Schett G, Bozec A, Raimondo MG:Reply to Correspondence on: 'Effects of different B-cell-depleting strategies on the lymphatic tissue'.Ann Rheum Dis. 2026;85(1): e1-e2
Rauner M, Bozec A:Mechanisms of osteoclast activation in inflammatory bone loss in rheumatoid arthritis.Nat Rev Rheumatol. 2026;22(1): 42-61
Ringer M, Maccataio A, Zapf R, Gaculenko A, Adam S, Aust O, Loskarn S, Luther J, Aksoy B, Popp V, Weidner D, Eck M, Munoz L, Bozec A, Uderhardt S, Bäuerle T, Schett G, Krönke G, Hüffmeier U, Frey S, Steffen U:Loss of myeloperoxidase aggravates skin and joint inflammation in the mannan-induced psoriatic arthritis mouse model.J Leukoc Biol. 2025;117(9):
Grötsch B, Bozec A, Schett G:Models of Rheumatoid Arthritis.Methods Mol Biol. 2025;2885(): 345-357
Bucci L, Böltz S, Hagen M, Tur C, Nöthling DM, Rothe T, Wirsching A, Auth J, Wacker J, Eckstein M, Alivernini S, Bozec A, Bergmann C, D'Agostino MA, Munoz L, Rech J, Kihm L, Raimondo MG, Schett G, Grieshaber-Bouyer R:BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease.N Engl J Med. 2025;393(15): 1544-1547
Andreev D, Porschitz P, Weidner D, Song R, Weider M, Schett G, Gölz L, Bozec A:A multidimensional analysis of temporomandibular joint and ankle joint erosion in inflammatory arthritis.Front Immunol. 2025;16():
Garantziotis P, Beretta L, Lindblom J, Nikolopoulos D, Grieshaber-Bouyer R, Moysidou GS, Hagen M, Wirsching A, Taubmann J, Bergmann C, Bozec A, Barturen G, Fanouriakis A, Bertsias GK, Schneider M, Boumpas D, Alarcon-Riquelme M, Schett G, Parodis I:DISTINCT MOLECULAR RESPONSES TO CD19 CAR-T CELL THERAPY VERSUS STANDARD PHARMACOTHERAPY IN SYSTEMIC LUPUS ERYTHEMATOSUSAnn Rheum Dis. 2025;84 Suppl 1(): 2177-2177
Bucci L, Boeltz S, Hagen M, Noethling DM, Rothe T, Tur C, Wirsching A, Auth J, Wacker J, Eckstein M, Alivernini S, Bozec A, Bergmann C, DAgostino MA, Raimondo MG, Schett G, Grieshaber-Bouyer R:SAFETY AND EFFICACY OFT CELL ENGAGER THERAPY IN PATIENTS WITH REFRACTORY AUTOIMMUNE DISEASEAnn Rheum Dis. 2025;84 Suppl 1():
Yang Y, Fan Y, Jain S, Ding Z, Liu H, Horenberg AL, Sun H, Killer MS, Chandra A, Dalan R, Chandran M, Yap L, Chen J, Verma NK, Cheung C, Risbud MV, Bozec A, Ramadan K, Cohen-Solal M, Grayson WL, Ramasamy SK, Kusumbe AP:Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow.bioRxiv. 2025;():
Hagen M, Wirsching A, Mueller F, Kharboutli S, Bergmann C, Boeltz S, Taubmann J, Tur C, Bucci L, Voelkl S, Aigner M, Kretschmann S, Spoerl S, Vasova I, Aletaha D, Kiener H, Natalello G, Locatelli F, D'Agostino MA, Bozec A, Hanssens L, Grieshaber-Bouyer R, Mackensen A, Schett G:SAFETY AND PRELIMINARY EFFICACY OF CD19 CAR T-CELL TREATMENT IN RHEUMATIC DISEASE-DATA FROM THE PHASE I/II CASTLE BASKET STUDYAnn Rheum Dis. 2025;84 Suppl 1():
Bucci L, Rothe T, Mueller F, Taubmann J, Hagen M, Bergmann C, Tur C, Munoz L, Wilhelm A, Gerlach R, Schaefer S, Voelkl S, Aigner M, Grieshaber-Bouyer R, Kroenke G, Bozec A, Winkler T, Mackensen A, Schett G:EFFECTS OF CAR-T CELL TREATMENT ON B CELL IMMUNITY IN SYSTEMIC AUTOIMMUNE DISEASESAnn Rheum Dis. 2025;83 Suppl 1():
Garantziotis P, Beretta L, Lindblom J, Nikolopoulos D, Bertsias G, Hagen M, Taubmann J, Wirsching A, Bozec A, Grieshaber-Bouyer R, Schneider M, Barturen G, Boumpas D, Alarcon-Riquelme M, Schett G, Parodis I, PRECISESADS CLIN CONSORTIUM:DISTINCT MOLECULAR PROFILES OF REMISSION POST-CD19 CAR-T CELL THERAPY VERSUS STANDARD IMMUNOSUPPRESSION IN SYSTEMIC LUPUS ERYTHEMATOSUSJ Rheumatol. 2025;52 Suppl 1(): 8-8
Tur C, Eckstein M, Bucci L, Auth J, Bergmann C, Rauber S, Hagen M, Nöthling DM, Böltz S, Wirsching A, Tascilar K, Fagni F, Corte G, Rius Rigau A, Qin Y, Garantziotis P, Taubmann J, Wacker J, Ramming A, D Agostino MA, Rauch S, Hartmann A, Müller F, Mackensen A, Grieshaber-Bouyer R, Schett G, Bozec A, Raimondo MG:Effects of different B-cell-depleting strategies on the lymphatic tissue.Ann Rheum Dis. 2025;84(12): 2065-2074
Knode BK, Beeghly GF, Schutrum BE, Wang D, Zheng Y, Battistella A, Goswami R, Eom CY, Bozec A, Guck J, Nishimura N, Girardo S, O'Hern CS, Fischbach C:Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.bioRxiv. 2025;():
Wu L, Zhang Q, Tang Z, Li Y, Wu T, Chen L, Tan C, Zhang L, Ji X, Zhang S, Wu Y, Bozec A, Zaiss MM, Luo Y:Gut microbiota-derived tryptophan indole metabolites ameliorate collagen-induced arthritis in mice via aryl hydrocarbon receptor activation in T cells and intestinal epithelial cells.Arthritis Rheumatol. 2025;():
Muller F, Hagen M, Spoerl S, Wirsching A, Kharboutli S, Kretschmann S, Tascilar K, Taubmann J, Bucci L, Raimondo M, Bergmann C, Tur C, Munoz L, Vasova I, Gerbitz A, Spriewald B, Ginnarelli D, Locatelli F, D'agostino MA, Hanssen L, Bozec A, Grieshaber-Boyer R, Miltenyi S, Aigner M, Voelkl S, Schett G, Mackensen A:Safety and preliminary efficacy of anti-CDI9 CART cells zorpocabtagene-autoleucel in systemic autoimmune diseases: Final analysis of the castle trialBlood. 2025;146 Suppl 1(): 2380-2381
Deschner J, Schröder A, Weber M, Galler K, Proff P, Kirschneck C, Bozec A, Jantsch J:Advancing oral immunology for improving oral health.J Orofac Orthop. 2025;86(1): 33-37
Auth J, Müller F, Völkl S, Bayerl N, Distler JHW, Tur C, Raimondo MG, Chenguiti Fakhouri S, Atzinger A, Coppers B, Eckstein M, Liphardt AM, Bäuerle T, Tascilar K, Aigner M, Kretschmann S, Wirsching A, Taubmann J, Hagen M, Györfi AH, Kharboutli S, Krickau T, Dees C, Spörl S, Rothe T, Harrer T, Bozec A, Grieshaber-Bouyer R, Fuchs F, Kuwert T, Berking C, Horch RE, Uder M, Mackensen A, Schett G, Bergmann C:CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series.Lancet Rheumatol.. 2025;7(2): e83-e93
Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, Wirtz S, Schett G, Bozec A:Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation.Cell Mol Immunol. 2025;22(1): 54-67
Bergmann C, Chenguiti Fakhouri S, Trinh-Minh T, Filla T, Rius Rigau A, Ekici AB, Merlevede B, Hallenberger L, Zhu H, Dees C, Matei AE, Auth J, Györfi AH, Zhou X, Rauber S, Bozec A, Dickel N, Liang C, Kunz M, Schett G, Distler JHW:Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP-1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies.Arthritis Rheumatol. 2025;77(1): 92-98
Taubmann J, Mueller F, Mutlu MY, Voelkl S, Aigner M, Bozec A, Mackensen A, Grieshaber-Bouyer R, Schett G:Correction to CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus.Arthritis Rheumatol. 2025;77(3):
Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A:Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.Bone Res. 2025;13(1):
Taubmann J, Müller F, Yalcin Mutlu M, Völkl S, Aigner M, Bozec A, Mackensen A, Grieshaber-Bouyer R, Schett G:CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus.Arthritis Rheumatol. 2024;76(4): 497-504
Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A:L-arginine metabolism inhibits arthritis and inflammatory bone loss.Ann Rheum Dis. 2024;83(1): 72-87
Andreev D, Kachler K, Liu M, Chen Z, Krishnacoumar B, Ringer M, Frey S, Krönke G, Voehringer D, Schett G, Bozec A:Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase.Nat Commun. 2024;15(1):
Kachler K, Andreev D, Thapa S, Royzman D, Gießl A, Karuppusamy S, Llerins Perez M, Liu M, Hofmann J, Gessner A, Meng X, Rauber S, Steinkasserer A, Fromm M, Schett G, Bozec A:Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis.Ann Rheum Dis. 2024;83(12): 1691-1706
Hagen M, Bucci L, Böltz S, Nöthling DM, Rothe T, Anoshkin K, Raimondo MG, Tur C, Wirsching A, Wacker J, Düsing C, Distler JHW, Kuwert T, Bozec A, Ramming A, Schett G, Grieshaber-Bouyer R:BCMA-Targeted T-Cell-Engager Therapy for Autoimmune Disease.N Engl J Med. 2024;391(9): 867-869
Wilhelm A, Chambers D, Müller F, Bozec A, Grieshaber-Bouyer R, Winkler T, Mougiakakos D, Mackensen A, Schett G, Krönke G:Selective CAR T cell-mediated B cell depletion suppresses IFN signature in SLE.JCI Insight. 2024;9(12):
Lyu P, Wen J, Zhang W, Liu N, Stolzer I, Gießl A, Jia Y, Mauro D, Zhang F, Ciccia F, Soulat D, Günther C, Schett G, Bozec A:Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery.Ann Rheum Dis. 2024;83(8): 984-997
Jia Y, Zhang F, Meng X, Andreev D, Lyu P, Zhang W, Lai C, Schett G, Bozec A:Osteocytes support bone metastasis of melanoma cells by CXCL5.Cancer Lett. 2024;590():
Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Pachowsky M, Eckstein M, Alivernini S, Zoli A, Krönke G, Uderhardt S, Bozec A, D'Agostino MA, Schett G, Grieshaber-Bouyer R:Bispecific T cell engager therapy for refractory rheumatoid arthritis.Nat Med. 2024;30(6): 1593-1601
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G:CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.N Engl J Med. 2024;390(8): 687-700
Kachler K, Andreev D, Schett G, Bozec A:Inhibition of aerobic glycolysis viaAcod1 suppresses osteoclast differentiation and reduces bone erosion in arthritisJ Bone Miner Res. 2024;39 Suppl 1(): 219-219
Tur C, Eckstein M, Velden J, Rauber S, Bergmann C, Auth J, Bucci L, Corte G, Hagen M, Wirsching A, Grieshaber-Bouyer R, Reis P, Kittan N, Wacker J, Rius Rigau A, Ramming A, D'Agostino MA, Hartmann A, Müller F, Mackensen A, Bozec A, Schett G, Raimondo MG:CD19-CAR T-cell therapy induces deep tissue depletion of B cells.Ann Rheum Dis. 2024;():
Schett G, Mueller F, Hagen M, Wirsching A, Bohr D, Bergmann C, Tur C, Voelkl S, Aigner M, Kretschmann S, Spoerl S, Kharboutli S, Vasova I, Aletaha D, Kiener H, Natalello G, Locatelli F, D'Agostino MA, Bozec A, Grieshaber-Bouyer R, MAckensen A:Safety and Preliminary Efficacy of CD19 CAR-T Cell Treatment in Rheumatic Disease - Data from the First Part of the Phase I/II CASTLE Basket StudyArthritis Rheumatol. 2024;76 Suppl 9(): 3573-3574
Tur C, Eckstein M, Joachim V, Bergmann C, Auth J, Bucci L, Corte G, Hagen M, Wirsching A, Grieshaber-Bouyer R, Reis P, Kittan N, Wacker J, Rauber S, Rigau A, Ramming A, D'Agostino MA, Hartmann A, Mueller F, MAckensen A, Bozec A, Schett G, Raimondo MG:Deep B Cell Tissue Depletion Following Anti-CD19 CART Cells TherapyArthritis Rheumatol. 2024;76 Suppl 9(): 1629-1631
Safhi M, Kronke G, Schett G, Bozec A, Andreev D:Eosinophil peroxidase induces a pro-resolving phenotype in macrophagesEur J Immunol. 2024;54 Suppl 1(): 87-87
Chou J, Grieshaber-Bouyer R, Bohr D, Bergmann C, Taubmann J, Mueller F, Bozec A, Rothe T, Mackensen A, Chung J, Schett G:Serum Proteomic Analysis Identifies Markers Associated with Anti-CD19 CAR T Therapeutic Response in Autoimmune DiseasesMol Ther. 2024;32 Suppl 1(4): 849-850
Wilhelm A, Chambers D, Mueller F, Bozec A, Grieshaber-Bouyer R, Winkler T, Mougiakakos D, Mackensen A, Schett G, Kroenke G:Selective CAR-T cell mediated B cell depletion suppresses interferon signature in systemic lupus erythematosusEur J Immunol. 2024;54 Suppl 1(): 1519-1519
Chou J, Grieshaber-Bouyer R, Wu MJ, Bergmann C, Taubmann J, Mueller F, Bozec A, Rothe T, MAckensen A, Podoll A, Gutman J, Haghikia A, Mougiakakos D, Tong G, Kheradpour P, Kim F, Ramesan P, Kwong B, Qu K, Ganguly B, Borie D, Chung J, Schett G:Comprehensive Immune Profiling of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy in Patients with Autoimmune DiseaseArthritis Rheumatol. 2024;76 Suppl 9(): 1623-1626
Hagen M, Bucci L, Boeltz S, Noethling DM, Rothe T, Raimondo MG, Tur C, Wirsching A, Wacker J, Bozec A, Schett G, Grieshaber-Bouyer R:Safety of Bispecific T-cell Engager Therapy in Autoimmune DiseaseArthritis Rheumatol. 2024;76 Suppl 9(): 2299-2300
Bucci L, Hagen M, Boeltz S, Noethling DM, Rothe T, Raimondo MG, Tur C, Wirsching A, Wacker J, Bozec A, Schett G, Grieshaber-Bouyer R:BCMA-targeted Bispecific T Cell-engager Therapy of Autoimmune DiseaseArthritis Rheumatol. 2024;76 Suppl 9(): 5403-5405
Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Eckstein M, Alivernini S, Zoli A, Bozec A, D'agostino MA, Schett G, Grieshaber-Bouyer. R:BITEING MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS WITH CD19-T CELL ENGAGERSAnn Rheum Dis. 2024;83 Suppl 1():
Taubmann J, Mueller F, Fagni F, Bergmann C, Tur C, Bucci L, Voelki S, Aigner M, Hagen M, Grieshaber-Bouyer R, Mougiakakos D, Kroenke G, Korganow AS, Farge D, Bozec A, Mackensen A, Schett G:LONG-TERM SAFETY AND EFFICACY OF CAR-T CELL TREATMENT IN SEVERE AND TREATMENT REFRACTORY AUTOIMMUNE DISEASEAnn Rheum Dis. 2024;83 Suppl 1():
Schett G, Bohr D, Mueller F, Hagen M, Bergmann C, Tur C, Voelkl S, Aigner M, Krestchmann S, Spoerl S, Vasova I, Aletaha D, Kiener H, Natalello G, Grieshaber-Bouyer R, Bozec A, Locatelli F, D'agostino MA, Mackensen A:SAFETY AND PRELIMINARY EFFICACY OF CD19 CAR-T CELL TREATMENT IN RHEUMATIC DISEASE-DATA FROM THE FIRST PART OFTHE PHASE I/II CASTLE BASKET STUDYAnn Rheum Dis. 2024;83 Suppl 1():
Lai C, Heinemann J, Schleicher U, Schett G, Bogdan C, Bozec A, Soulat D:Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass.J Bone Miner Res. 2023;38(1): 86-102
Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R:Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.EMBO Mol Med. 2023;15(2):
Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A:High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production.Cell Rep. 2023;42(7):
Sommer J, Ehnis H, Seitz T, Schneider J, Wild AB, Moceri S, Buechler C, Bozec A, Weber GF, Merkel S, Beckervordersandforth R, Steinkasserer A, Schüle R, Trebicka J, Hartmann A, Bosserhoff A, von Hörsten S, Dietrich P, Hellerbrand C:Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity.Int J Mol Sci. 2023;24(19):
Luo Y, Tong Y, Wu L, Niu H, Li Y, Su LC, Wu Y, Bozec A, Zaiss MM, Qing P, Zhao H, Tan C, Zhang Q, Zhao Y, Tang H, Liu Y:Alteration of Gut Microbiota in Individuals at High-Risk for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance.Arthritis Rheumatol. 2023;75(10): 1736-1748
Andreev D, Schett G, Bozec A:Eosinophils counteract osteoclast-mediated bone degradation via the secretion of eosinophil peroxidaseJ Bone Miner Res. 2023;38 Suppl 2(): 273-273
Scaeffer A, Tsoukala J, Mosa M, Soetopo D, Weitmann M, Kisel W, Thevissen S, Beavarlet J, Drotleff B, Alexandrov T, Sevenich L, Broggini T, Czabanka M, Boenig H, Goetze K, Bozec A, Pantel K, Hofbauer L, Rauner M, Medyouf H:Aging of the bone marrow niche awakens dormant breast cancer cells and promotes overt bone metastasisJ Bone Miner Res. 2023;38 Suppl 2(): 115-115
Almenara-Fuentes L, Rodriguez-Fernandez S, Rosell-Mases E, Kachler K, You A, Salvado M, Andreev D, Steffen U, Bang H, Bozec A, Schett G, Le Panse R, Verdaguer J, Dalmases M, Rodriguez-Vidal S, Barneda-Zahonero B, Vives-Pi M:A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens.Nanomedicine. 2023;48():
Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Sembritzki NK, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Lenz B, Schumann G, Kornhuber J, Müller CP:Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males.Cereb Cortex. 2023;33(3): 844-864
Kadur Lakshminarasimha Murthy P, Xi R, Arguijo D, Everitt JI, Kocak DD, Kobayashi Y, Bozec A, Vicent S, Ding S, Crawford GE, Hsu D, Tata PR, Reddy T, Shen X:Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity.Dev Cell. 2022;57(3): 310-328.e9
Urbanczyk S, Baris OR, Hofmann J, Taudte RV, Guegen N, Golombek F, Castiglione K, Meng X, Bozec A, Thomas J, Weckwerth L, Mougiakakos D, Schulz SR, Schuh W, Schlötzer-Schrehardt U, Steinmetz TD, Brodesser S, Wiesner RJ, Mielenz D:Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle.Cell Rep. 2022;39(10):
Marino S, Hannemann N, Bishop RT, Zeng F, Carrasco G, Meurisse S, Li B, Sophocleous A, Sparatore A, Baeuerle T, Vukicevic S, Auberval M, Mollat P, Bozec A, Idris AI:Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis.Biochem Pharmacol. 2022;195():
Wen J, Lyu P, Stolzer I, Xu J, Gießl A, Lin Z, Andreev D, Kachler K, Song R, Meng X, Cao S, Guggino G, Ciccia F, Günther C, Schett G, Bozec A:Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis.Ann Rheum Dis. 2022;81(8): 1119-1130
Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E, Mühl-Zürbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bäuerle T, Nagel L, Schett G, Bozec A, Steinkasserer A:The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.Front Immunol. 2022;13():
Andreev D, Kachler K, Schett G, Bozec A:Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism.Bone. 2022;162():
Meng X, Lin Z, Cao S, Janowska I, Sonomoto K, Andreev D, Katharina K, Wen J, Knaup KX, Wiesener MS, Krönke G, Rizzi M, Schett G, Bozec A:Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss.Bone Res. 2022;10(1):
Groetsch B, Schachtschabel E, Tripal P, Schmid B, Smith AS, Schett G, Bozec A:Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts.Front Immunol. 2022;13():
Gregoric G, Gaculenko A, Nagel L, Popp V, Maschauer S, Prante O, Saake M, Schett G, Uder M, Ellmann S, Bozec A, Bäuerle T:Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT.Cancers (Basel). 2022;14(10):
Li Y, Cao S, Gaculenko A, Zhan Y, Bozec A, Chen X:Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis.Front Endocrinol (Lausanne). 2022;13():
Zhang W, Lyu P, Andreev D, Jia Y, Zhang F, Bozec A:Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma.Front Cell Dev Biol. 2022;10():
Qin Y, Cai ML, Jin HZ, Huang W, Zhu C, Bozec A, Huang J, Chen Z:Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways.Ann Rheum Dis. 2022;81(11): 1504-1514
Dölling M, Eckstein M, Singh J, Schauer C, Schoen J, Shan X, Bozec A, Knopf J, Schett G, Muñoz LE, Herrmann M:Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction.Front Immunol. 2022;13():
Chen GL, Li R, Chen XX, Wang J, Cao S, Song R, Zhao MC, Li LM, Hannemmann N, Schett G, Qian C, Bozec A:Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b.Cell Death Differ. 2021;28(4): 1364-1378
Andreev D, Liu M, Kachler K, Llerins Perez M, Kirchner P, Kölle J, Gießl A, Rauber S, Song R, Aust O, Grüneboom A, Kleyer A, Cañete JD, Ekici A, Ramming A, Finotto S, Schett G, Bozec A:Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis.Ann Rheum Dis. 2021;80(4): 451-468
Heinen H, Seyler L, Popp V, Hellwig K, Bozec A, Uder M, Ellmann S, Bäuerle T:Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis.Bone. 2021;144():
Vielreicher M, Bozec A, Schett G, Friedrich O:Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging.Front Bioeng Biotechnol. 2021;9():
Gaculenko A, Gregoric G, Popp V, Seyler L, Ringer M, Kachler K, Wu Z, Kisel W, Hofbauer C, Hofbauer LC, Uder M, Schett G, Bäuerle T, Bozec A:Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents.J Bone Miner Res. 2021;36(12): 2440-2452
Cao S, Schnelzer A, Hannemann N, Schett G, Soulat D, Bozec A:The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model.Front Immunol. 2021;12():
Bergmann C, Hallenberger L, Chenguiti Fakhouri S, Merlevede B, Brandt A, Dees C, Zhu H, Zehender A, Zhou X, Schwab A, Chen CW, Györfi AH, Matei AE, Chakraborty D, Trinh-Minh T, Rauber S, Coras R, Bozec A, Kreuter A, Ziemer M, Schett G, Distler JHW:X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc).Ann Rheum Dis. 2021;80(8): 1048-1056
Degboé Y, Sunzini F, Sood S, Bozec A, Sokolova MV, Zekovic A, McInnes IB, Schett G, Goodyear CS:Apremilast inhibits inflammatory osteoclastogenesis.Rheumatology (Oxford). 2021;61(1): 452-461
Hülser ML, Luo Y, Frommer K, Hasseli R, Köhler K, Diller M, Van Nie L, Rummel C, Roderfeld M, Roeb E, Schett G, Bozec A, Müller-Ladner U, Neumann E:Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model.Sci Rep. 2021;11(1):
Hofbauer LC, Bozec A, Rauner M, Jakob F, Perner S, Pantel K:Novel approaches to target the microenvironment of bone metastasis.Nat Rev Clin Oncol. 2021;18(8): 488-505
Meng X, Wielockx B, Rauner M, Bozec A:Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease.Front Cell Dev Biol. 2021;9():
Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Tesch N, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Gulbins E, Lenz B, Schumann G, Kornhuber J, Müller CP:Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects.Mol Psychiatry. 2021;26(12): 7403-7416
Weber M, Wehrhan F, Deschner J, Sander J, Ries J, Möst T, Bozec A, Gölz L, Kesting M, Lutz R:The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases.Int J Mol Sci. 2021;22(3):
Lin Z, Meng X, Wen J, Corral JM, Andreev D, Kachler K, Schett G, Chen X, Bozec A:Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients.Front Oncol. 2020;10():
Andreev D, Liu M, Weidner D, Kachler K, Faas M, Grüneboom A, Schlötzer-Schrehardt U, Muñoz LE, Steffen U, Grötsch B, Killy B, Krönke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A:Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.J Clin Invest. 2020;130(9): 4811-4830
Sauermilch HM, Hulser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E:COMPARISON OF INFLAMMATION DURING METABOLIC CHANGES IN RHEUMATOID AND OSTEOARTHRITIS MOUSE MODELSAnn Rheum Dis. 2020;79 Suppl 1(): 242-243
Liu M, Andreev D, Kachler K, Koelle J, Rauber S, Ramming A, Finotto S, Schett G, Bozec A:ALLERGIC ASTHMA INDUCES THE ACCUMULATION OF SYNOVIAL RESIDENT EOSINOPHILS, TRIGGERING THE RESOLUTION OF INFLAMMATORY ARTHRITISAnn Rheum Dis. 2020;79 Suppl 1(): 86-86
Cao S, Chen X, Schett G, Bozec A:L-ARGININE SUPPLEMENTATION AMELIORATES BONE EROSION IN RHEUMATOID ARTHRITIS THROUGH INHIBITION OF RANKL/RANK/TRAF6 PATHWAY AND REPROGRAMMING OSTEOCLAST METABOLISMAnn Rheum Dis. 2020;79 Suppl 1(): 927-927
Seidel CL, Gerlach RG, Wiedemann P, Weider M, Rodrian G, Hader M, Frey B, Gaipl US, Bozec A, Cieplik F, Kirschneck C, Bogdan C, Gölz L:Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile.Int J Mol Sci. 2020;21(21):
Ellmann S, Seyler L, Gillmann C, Popp V, Treutlein C, Bozec A, Uder M, Bäuerle T:Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model.J Vis Exp. 2020;(162):
Weider M, Schröder A, Docheva D, Rodrian G, Enderle I, Seidel CL, Andreev D, Wegner M, Bozec A, Deschner J, Kirschneck C, Proff P, Gölz L:A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress.Int J Mol Sci. 2020;21(21):
Schaeffer A, Czlonka E, Tirado-Gonzalez I, Bose T, Beauvarlet J, Kur I, Bozec A, Bonig H, Brandts CH, Platzbecker U, Gotze KS, Medyouf H:Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDSBlood. 2020;136 Suppl 1():
Liphardt AM, Windahl SH, Sehic E, Hannemann N, Gustafsson KL, Bozec A, Schett G, Engdahl C:Changes in mechanical loading affect arthritis-induced bone loss in miceBone. 2020;131():
Zaiss MM, Hall C, McGowan NWA, Babb R, Devlia V, Lucas S, Meghji S, Henderson B, Bozec A, Schett G, David JP, Panayi GS, Grigoriadis AE, Corrigall VM:Binding Immunoglobulin Protein (BIP) Inhibits TNF-α-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model.ACR Open Rheumatol. 2019;1(6): 382-393
Grötsch B, Lux A, Rombouts Y, Hoffmann AC, Andreev D, Nimmerjahn F, Xiang W, Scherer HU, Schett G, Bozec A:Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss.J Bone Miner Res. 2019;34(7): 1352-1365
Grötsch B, Bozec A, Schett G:In Vivo Models of Rheumatoid Arthritis.Methods Mol Biol. 2019;1914(): 269-280
Royzman D, Andreev D, Stich L, Rauh M, Bäuerle T, Ellmann S, Boon L, Kindermann M, Peckert K, Bozec A, Schett G, Steinkasserer A, Zinser E:Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.Front Immunol. 2019;10():
Ellmann S, Seyler L, Evers J, Heinen H, Bozec A, Prante O, Kuwert T, Uder M, Bäuerle T:Prediction of early metastatic disease in experimental breast cancer bone metastasis by combining PET/CT and MRI parameters to a Model-Averaged Neural Network.Bone. 2019;120(): 254-261
Schröder A, Neubert P, Titze J, Bozec A, Neuhofer W, Proff P, Kirschneck C, Jantsch J:Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5.JCI Insight. 2019;4(23):
Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Canete JD, Chen XX, Baeuerle T, Vera J, Bogdan C, Schett G, Bozec A:Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.J Clin Invest. 2019;129(7): 2669-2684
Sauermilch HM, Huelser ML, Schreiyaeck C, Luo YB, Bozec A, Schett G, Mueller-Ladner U, Neumann E:Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse ModelsArthritis Rheumatol. 2019;71():
Sauermilch HM, Huelser ML, Schreiyaeck C, Luo Y, Bozec A, Schett G, Mueller-Ladner U, Neumann E:EFFECT OF HIGH FAT DIET ON SYSTEMIC AND LOCAL INFLAMMATION IN THE CONTEXT OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS MOUSE MODELSAnn Rheum Dis. 2019;78(): A72-A72

Publikationen: Prof. Dr. rer. nat. A. Bozec

Notfall

Notfallinformationen UKER

Patienten & Besucher

Ärzte & Zuweiser

Forschung

Lehre