Publikationen: Prof. Dr. rer. nat. A. Bozec
- Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase. Nat Commun. 2024;15(1):
- L-arginine metabolism inhibits arthritis and inflammatory bone loss. Ann Rheum Dis. 2024;83(1): 72-87
- CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2024;76(4): 497-504
- Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass. J Bone Miner Res. 2023;38(1): 86-102
- Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 2023;15(2):
- High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production. Cell Rep. 2023;42(7):
- Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. Int J Mol Sci. 2023;24(19):
- Advancing oral immunology for improving oral health. J Orofac Orthop. 2023;():
- Alteration of Gut Microbiota in Individuals at High-Risk for Rheumatoid Arthritis Associated With Disturbed Metabolome and the Initiation of Arthritis Through the Triggering of Mucosal Immunity Imbalance. Arthritis Rheumatol. 2023;75(10): 1736-1748
- A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens. Nanomedicine. 2023;48():
- Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males. Cereb Cortex. 2023;33(3): 844-864
- Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity. Dev Cell. 2022;57(3): 310-328.e9
- Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle. Cell Rep. 2022;39(10):
- Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis. Biochem Pharmacol. 2022;195():
- Epithelial HIF2α expression induces intestinal barrier dysfunction and exacerbation of arthritis. Ann Rheum Dis. 2022;81(8): 1119-1130
- The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. Front Immunol. 2022;13():
- Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism. Bone. 2022;162():
- Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res. 2022;10(1):
- Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts. Front Immunol. 2022;13():
- Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT. Cancers (Basel). 2022;14(10):
- Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis. Front Endocrinol (Lausanne). 2022;13():
- Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma. Front Cell Dev Biol. 2022;10():
- Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways. Ann Rheum Dis. 2022;81(11): 1504-1514
- Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction. Front Immunol. 2022;13():
- Murine Metatarsus Bone and Joint Collagen-I Fiber Morphologies and Networks Studied With SHG Multiphoton Imaging. Front Bioeng Biotechnol. 2021;9():
- Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents. J Bone Miner Res. 2021;36(12): 2440-2452
- The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model. Front Immunol. 2021;12():
- X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc). Ann Rheum Dis. 2021;80(8): 1048-1056
- Apremilast inhibits inflammatory osteoclastogenesis. Rheumatology (Oxford). 2021;61(1): 452-461
- Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model. Sci Rep. 2021;11(1):
- Novel approaches to target the microenvironment of bone metastasis. Nat Rev Clin Oncol. 2021;18(8): 488-505
- Hypoxia-Inducible Factors Regulate Osteoclasts in Health and Disease. Front Cell Dev Biol. 2021;9():
- Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects. Mol Psychiatry. 2021;26(12): 7403-7416
- The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases. Int J Mol Sci. 2021;22(3):
- Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. Cell Death Differ. 2021;28(4): 1364-1378
- Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis. Ann Rheum Dis. 2021;80(4): 451-468
- Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis. Bone. 2021;144():
- Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients. Front Oncol. 2020;10():
- Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest. 2020;130(9): 4811-4830
- COMPARISON OF INFLAMMATION DURING METABOLIC CHANGES IN RHEUMATOID AND OSTEOARTHRITIS MOUSE MODELS Ann Rheum Dis. 2020;79 Suppl 1(): 242-243
- ALLERGIC ASTHMA INDUCES THE ACCUMULATION OF SYNOVIAL RESIDENT EOSINOPHILS, TRIGGERING THE RESOLUTION OF INFLAMMATORY ARTHRITIS Ann Rheum Dis. 2020;79 Suppl 1(): 86-86
- L-ARGININE SUPPLEMENTATION AMELIORATES BONE EROSION IN RHEUMATOID ARTHRITIS THROUGH INHIBITION OF RANKL/RANK/TRAF6 PATHWAY AND REPROGRAMMING OSTEOCLAST METABOLISM Ann Rheum Dis. 2020;79 Suppl 1(): 927-927
- Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile. Int J Mol Sci. 2020;21(21):
- Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model. J Vis Exp. 2020;(162):
- A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress. Int J Mol Sci. 2020;21(21):
- Changes in mechanical loading affect arthritis-induced bone loss in mice Bone. 2020;131():
- Development and Exploitation of a Fully Human and Modular Organotypic Bone Marrow Niche Model to Study the Role of Stroma-Produced Factors in Human MDS Blood. 2020;136 Suppl 1():
- Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat Rev Rheumatol. 2019;15(1): 9-17
- Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases. FASEB J. 2019;33(1): 1401-1414
- Binding Immunoglobulin Protein (BIP) Inhibits TNF-α-Induced Osteoclast Differentiation and Systemic Bone Loss in an Erosive Arthritis Model. ACR Open Rheumatol. 2019;1(6): 382-393
- Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss. J Bone Miner Res. 2019;34(7): 1352-1365
- In Vivo Models of Rheumatoid Arthritis. Methods Mol Biol. 2019;1914(): 269-280
- Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner. Front Immunol. 2019;10():
- Prediction of early metastatic disease in experimental breast cancer bone metastasis by combining PET/CT and MRI parameters to a Model-Averaged Neural Network. Bone. 2019;120(): 254-261
- Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. JCI Insight. 2019;4(23):
- Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. J Clin Invest. 2019;129(7): 2669-2684
- Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse Models Arthritis Rheumatol. 2019;71():
- EFFECT OF HIGH FAT DIET ON SYSTEMIC AND LOCAL INFLAMMATION IN THE CONTEXT OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS MOUSE MODELS Ann Rheum Dis. 2019;78(): A72-A72
- How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis Front Immunol. 2019;10():
- Obesity as an Influence Parameter of rheumatoid Arthritis and Osteoarthritis (Arthrosis) in the Mouse Model Internist (Berl). 2019;60(): S39-S39
- INHIBITION OF ARGINASE-1 EXPRESSION BY THE TRANSCRIPTION FACTOR FRA-1 IN MACROPHAGES EXACERBATES RHEUMATOID ARTHRITIS INFLAMMATION Ann Rheum Dis. 2019;78(): A27-A27
- Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner. Arthritis Res Ther. 2018;20(1):
- [New insights into the function of bone marrow]. Z Rheumatol. 2018;77(Suppl 1): 4-7
- ADIPOCYTOKINES LINKING OBESITY AND OSTEOARTHRITIS Ann Rheum Dis. 2018;77(): A49-A50
- Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24(1): 169-180
- Adipokine in the Arthritis Mouse Model Internist (Berl). 2018;59(): S35-S35
- Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin. Mol Cell Biol. 2018;38(22):
- Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models Arthritis Rheumatol. 2018;70():
- THE AP1 TRANSCRIPTION FACTOR CJUN AMPLIFIES HEDGEHOG-INDUCED FIBROBLAST ACTIVATION AND TISSUE FIBROSIS Ann Rheum Dis. 2018;77(): 732-733
- DIET INDUCED METABOLIC CHANGES IN AN OSTEOARTHRITIS MOUSE MODEL Ann Rheum Dis. 2018;77(): 104-104
- Hypoxia-inducible factor-1? is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun. 2018;9(1): 251
- The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis. Ann Rheum Dis. 2018;77(1): 150-158
- Latest perspectives on macrophages in bone homeostasis. Pflugers Arch. 2017;469(3-4): 517-525
- An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8(): 14294
- The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages. J Immunol. 2017;198(9): 3605-3614
- T Regulatory Cells in Bone Remodelling. Curr Osteoporos Rep. 2017;15(3): 121-125
- Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription. J Exp Med. 2017;214(7): 2059-2071
- A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1. Cell Death Differ. 2017;24(7): 1239-1252
- Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017;23(8): 938-944
- Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone. 2017;105(): 35-41
- Influence of Swiprosin2/EFhd1 on the metabolic control of B cell differentiation and humoral immunity Eur J Immunol. 2017;47 2(): 96-96
- ADIPOKINES AS LINK BETWEEN ARTHRITIS AND METABOLISM Ann Rheum Dis. 2017;76 1(): A29-A30
- REGULATION OF ARTHRITIS BY TYPE 2 INNATE LYMPHOID CELLS Ann Rheum Dis. 2017;76 1(): A3-A3
- FRA-1 TRANSCRIPTION FACTOR EXPRESSION IN MACROPHAGES FOSTER INFLAMMATION DURING RHEUMATOID ARTHRITIS DEVELOPMENT Ann Rheum Dis. 2017;76 1(): A6-A6
- The Histone Demethylase Jumonji Domain-Containing Protein 3 (JMJD3) As Central Mediator of Fibroblast Activation Arthritis Rheumatol. 2017;69():
- IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis Arthritis Rheumatol. 2017;69():
- Adipocytokines in an Osteoarthritis Mouse Model Arthritis Rheumatol. 2017;69():
- Th2 and eosinophil responses ameliorate arthritis and inflammatory bone loss Eur J Immunol. 2017;47(): 132-132
- Inhibited Arginase-1 Expression by Fra-1 in Myeloid Cells Enhance Rheumatoid Arthritis Inflammation Eur J Immunol. 2017;47(): 252-252
- ABATACEPT BUT NOT TNF INHIBITORS BLOCK AUTOANTIBODY-MEDIATED CYTOKINE PRODUCTION BY MONOCYTES Ann Rheum Dis. 2017;76(): 848-849
- EPIGENETIC REGULATION OF FRA2 BY JMJD3 REGULATES FIBROBLAST ACTIVATION IN SYSTEMIC SCLEROSIS Ann Rheum Dis. 2017;76(): 892-893
- Adipocytokine as a Link between Metabolism and Osteoarthritis Internist (Berl). 2017;58(): S11-S12
- METABOLISM AND OSTEOARTHRITIS ARE LINKED BY ADIPOKINES Ann Rheum Dis. 2017;76(): 1063-1063
- Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1. Oncogene. 2016;35(22): 2852-61
- High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6. Oncotarget. 2016;7(18): 26653-69
- Th2 and eosinophil responses suppress inflammatory arthritis. Nat Commun. 2016;7(): 11596
- Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis. J Vis Exp. 2016;(112):
- Regulation of osteosarcoma cell lung metastasis by the c-Fos/AP-1 target FGFR1. Oncogene. 2016;35(22): 2948
- Inhibition of Osteoarthritis by Adipose-Derived Stromal Cells Overexpressing Fra-1 in Mice. Arthritis Rheumatol. 2016;68(1): 138-51
- An integrative cross-tumors approach identifies FOSL1 as an oncogene dependency in KRAS-driven lung cancer J Thorac Oncol. 2016;11 Suppl S(2): S51-S51