Publikationen der Medizinischen Klinik 3

Publikationsliste der Medizinischen Klinik 3

Mill L, Aust O, Ackermann JA, Burger P, Pascual M, Palumbo-Zerr K, Krönke G, Uderhardt S, Schett G, Clemen CS, Holtzhausen C, Jabari S, Schröder R, Maier A, Grüneboom A: Deep learning-based image analysis in muscle histopathology using photo-realistic synthetic data. Commun Med (Lond). 2025;5(1):
Uderhardt S, Neag G, Germain RN: Dynamic Multiplex Tissue Imaging in Inflammation Research. Annu Rev Pathol. 2024;19(): 43-67
Krishnacoumar B, Stenzel M, Garibagaoglu H, Omata Y, Sworn RL, Hofmann T, Ipseiz N, Czubala MA, Steffen U, Maccataio A, Stoll C, Böhm C, Herrmann M, Uderhardt S, Jenkins RH, Taylor PR, Grüneboom A, Zaiss MM, Schett G, Krönke G, Scholtysek C: Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors. Bone Res. 2024;12(1):
Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G: Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids. Nature. 2024;629(8010): 184-192
Bucci L, Hagen M, Rothe T, Raimondo MG, Fagni F, Tur C, Wirsching A, Wacker J, Wilhelm A, Auger JP, Pachowsky M, Eckstein M, Alivernini S, Zoli A, Krönke G, Uderhardt S, Bozec A, D'Agostino MA, Schett G, Grieshaber-Bouyer R: Bispecific T cell engager therapy for refractory rheumatoid arthritis. Nat Med. 2024;30(6): 1593-1601
Gessain G, Anzali AA, Lerousseau M, Mulder K, Bied M, Auperin A, Stockholm D, Signolle N, Sassi F, Marques Da Costa ME, Marchais A, Sayadi A, Weidner D, Uderhardt S, Blampey Q, Nakkireddy SR, Broutin S, Dutertre CA, Busson P, Walter T, Marhic A, Moya-Plana A, Guerlain J, Breuskin I, Casiraghi O, Gorphe P, Classe M, Scoazec JY, Blériot C, Ginhoux F: TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma. Cancer Discov. 2024;14(12): 2352-2366
Cai R, Scott O, Ye G, Le T, Saran E, Kwon W, Inpanathan S, Sayed BA, Botelho RJ, Saric A, Uderhardt S, Freeman SA: Pressure sensing of lysosomes enables control of TFEB responses in macrophages. Nat Cell Biol. 2024;26(8): 1247-1260
Pohl S, Akamp T, Smeda M, Uderhardt S, Besold D, Krastl G, Galler KM, Buchalla W, Widbiller M: Understanding dental pulp inflammation: from signaling to structure. Front Immunol. 2024;15():
Kayvanjoo AH, Splichalova I, Bejarano DA, Huang H, Mauel K, Makdissi N, Heider D, Tew HM, Balzer NR, Greto E, Osei-Sarpong C, Baßler K, Schultze JL, Uderhardt S, Kiermaier E, Beyer M, Schlitzer A, Mass E: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis. Elife. 2024;13():
Wegner A, Palmisano R, Uderhardt S: Functional In Vivo Imaging of Macrophages. Methods Mol Biol. 2024;2713(): 323-335
Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP: Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods. Eur J Immunol. 2023;53(11):
Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhöfer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann MH, Krönke G: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. J Exp Med. 2023;220(6):
Culemann S, Knab K, Euler M, Wegner A, Garibagaoglu H, Ackermann J, Fischer K, Kienhöfer D, Crainiciuc G, Hahn J, Grüneboom A, Nimmerjahn F, Uderhardt S, Hidalgo A, Schett G, Hoffmann MH, Krönke G: Addendum: Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes. J Exp Med. 2023;220(7):
Ullrich KA, Derdau J, Baltes C, Battistella A, Rosso G, Uderhardt S, Schulze LL, Liu LJ, Dedden M, Spocinska M, Kainka L, Kubánková M, Müller TM, Schmidt NM, Becker E, Ben Brahim O, Atreya I, Finotto S, Prots I, Wirtz S, Weigmann B, López-Posadas R, Atreya R, Ekici AB, Lautenschläger F, Guck J, Neurath MF, Zundler S: IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells. Gut. 2023;72(11): 2081-2094
Mackensen A, Mueller F, Mougiakakos D, Boltz S, Wilhelm A, Aigner M, Volkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rosler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Kronke G, Schett G: Author Correction: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2023;29(11):
Leppkes M, Lindemann A, Gößwein S, Paulus S, Roth D, Hartung A, Liebing E, Zundler S, Gonzalez-Acera M, Patankar JV, Mascia F, Scheibe K, Hoffmann M, Uderhardt S, Schauer C, Foersch S, Neufert C, Vieth M, Schett G, Atreya R, Kühl AA, Bleich A, Becker C, Herrmann M, Neurath MF: Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis. Gut. 2022;71(12): 2414-2429
Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G: Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2022;28(10): 2124-2132
Wagner F, Thies M, Gu M, Huang Y, Pechmann S, Patwari M, Ploner S, Aust O, Uderhardt S, Schett G, Christiansen S, Maier A: Ultralow-parameter denoising: Trainable bilateral filter layers in computed tomography. Med Phys. 2022;49(8): 5107-5120
Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, Thion MS, Zhang XM, Kong WT, Deloger M, Fontes V, Weiner A, Ee R, Dress R, Hang JW, Balachander A, Chakarov S, Malleret B, Dunsmore G, Cexus O, Chen J, Garel S, Dutertre CA, Amit I, Kipnis J, Ginhoux F: Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022;55(8): 1448-1465.e6
Iannacone M, Blériot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F: Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells. Immunity. 2022;55(7): 1141-1142
Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021;54(11): 2531-2546.e5
Uderhardt S, Knopf J, Herrmann M: Neutrophil swarm control: what goes up must come down. Signal Transduct Target Ther. 2021;6(1):
Bittel M, Reichert P, Sarfati I, Dressel A, Leikam S, Uderhardt S, Stolzer I, Phu TA, Ng M, Vu NK, Tenzer S, Distler U, Wirtz S, Rothhammer V, Neurath MF, Raffai RL, Günther C, Momma S: Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo. J Extracell Vesicles. 2021;10(12):
Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren DJ, Grinstein S: Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance Science. 2020;367(6475): 301-+
Uderhardt S, Martins AJ, Tsang JS, Lammermann T, Germain RN: Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage Cell. 2019;177(3): 541-+
Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan WP, Tsang JS, Torabi-Parizi P, Fraser IDC, Germain RN: IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses Elife. 2019;8():
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2018;215(3):
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol. 2017;18(1): 104-113
Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. J Exp Med. 2017;214(7): 2121-2138
Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB: Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Sci Signal. 2017;10(507):
Beyer C, Huang J, Beer J, Zhang Y, Palumbo-Zerr K, Zerr P, Distler A, Dees C, Maier C, Munoz L, Krönke G, Uderhardt S, Distler O, Jones S, Rose-John S, Oravecz T, Schett G, Distler JH: Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Ann Rheum Dis. 2015;74(6): 1317-24
Rothe T, Gruber F, Uderhardt S, Ipseiz N, Rössner S, Oskolkova O, Blüml S, Leitinger N, Bicker W, Bochkov VN, Yamamoto M, Steinkasserer A, Schett G, Zinser E, Krönke G: 12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function. J Clin Invest. 2015;125(5): 1944-54
Ipseiz N, Uderhardt S, Scholtysek C, Steffen M, Schabbauer G, Bozec A, Schett G, Krönke G: The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells. J Immunol. 2014;192(10): 4852-8
Beyer C, Beer J, Palumbo-Zer K, Zerr P, Distler A, Dees C, Munoz L, Kroenke G, Uderhardt S, Distler O, Ovarecz T, Schett G, Distler J: ACTIVATION OF LIVER X RECEPTORS INHIBITS EXPERIMENTAL FIBROSIS BY INTERFERING WITH INTERLEUKIN-6 RELEASE FROM MACROPHAGES Clin Exp Rheumatol. 2014;32 81(2): S65-S65
Uderhardt S, Herrmann M, Oskolkova O, Aschermann S, Bicker W, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov V, Schett G, Kroenke G: 12/15-LIPOXYGENASE ORCHESTRATES THE CLEARANCE OF APOPTOTIC CELLS AND MAINTAINS IMMUNOLOGIC TOLERANCE Ann Rheum Dis. 2013;71 Suppl 3(): 531-531
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G: PPAR?/? governs Wnt signaling and bone turnover. Nat Med. 2013;19(5): 608-13
Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Krönke G, Spencer B, Distler O, Schett G, Distler JH: Autophagy regulates TNF?-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 2013;72(5): 761-8
Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M: Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids. Cell Death Differ. 2013;20(9): 1230-40
Ipseiz N, Uderhardt S, Scholtysek C, Schett G, Kroenke G: NR4A1 mediates anti-inflammatory effects of apoptotic cells Immunology. 2012;137 Suppl 1(): 278-278
Ipseiz N, Uderhardt S, Schett GA, Kronke G: NR4A1 Mediates Anti-Inflammatory Effects of Apoptotic Cells Arthritis Rheum. 2012;64 Suppl S(10): S392-S392
Uderhardt S, Herrmann M, Oskolkova OV, Aschermann S, Bicker W, Ipseiz N, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Krönke G: 12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance. Immunity. 2012;36(5): 834-46
Rothe T, Zinser E, Rössner S, Uderhardt S, Bochkov V, Oskolkova O, Schett G, Steinkasserer A, Krönke G: 12/15-lipoxygenase-mediated lipid oxidation regulates maturation of dendritic cells Immunology. 2012;137 1(): 465-465
Uderhardt S, Rothe T, Zinser E, Oskolkova O, Herrmann M, Steinkasserer A, Bochkov V, Schett G, Krönke G: Enzymatic Lipid Oxidation Contributes to the Maintenance of Self-Tolerance by Regulating Antigen Clearance and Dendritic Cell Function. Arthritis Rheum. 2012;64 S(10): S462-S462
Uderhardt S, Krönke G: 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J Mol Med. 2012;90(11): 1247-56
Krönke G, Reich N, Scholtysek C, Akhmetshina A, Uderhardt S, Zerr P, Palumbo K, Lang V, Dees C, Distler O, Schett G, Distler JH: The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis. Ann Rheum Dis. 2012;71(6): 1081-7
Uderhardt S, Herrmann M, Oskolkova O, Aschermann S, Bicker W, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G, Krönke G: 12/15-LIPOXYGENASE ORCHESTRATES THE CLEARANCE OF APOPTOTIC CELLS AND MAINTAINS IMMUNOLOGIC TOLERANCE Ann Rheum Dis. 2012;71 1(): S2
Scholtysek C, Fu H, Katzenbeisser J, Uderhardt S, Boehm C, David JP, Desvergne B, Schett G, Kroenke G: PPARss REGULATES BONE-METABOLISM BY FACILITATING WNT-SIGNALLING Ann Rheum Dis. 2011;70 Suppl 2():
Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, Krönke G, Schett G: Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis. 2010;69(3): 592-7
Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A: R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum. 2010;62(8): 2303-12
Scholtysek C, Uderhardt S, Schett G, Krönke G: NR4A1 MODULATES THE INFLAMMATORY RESPONSE DURING MURINE EXPERIMENTAL ARTHRITIS Ann Rheum Dis. 2010;69 Suppl. (): A91 -
Krönke G, Uderhardt S, Katzenbeisser J, Schett G: The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation. Autoimmunity. 2009;42(4): 383-5
Krönke G, Katzenbeisser J, Uderhardt S, Zaiss MM, Scholtysek C, Schabbauer G, Zarbock A, Koenders MI, Axmann R, Zwerina J, Baenckler HW, van den Berg W, Voll RE, Kuhn H, Joosten LA, Schett G: 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol. 2009;183(5): 3383-9
Schett G, Stolina M, Dwyer D, Zack D, Uderhardt S, Krönke G, Kostenuik P, Feige U: Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis. Arthritis Rheum. 2009;60(9): 2644-54
Krönke G, Uderhardt S, Zhao J, Ah-Kim K, Binnerts M, Katzenbeisser J, Schett G, Abo A: R-spondin 1 protects from bone loss in Htnf transgenic and ovariectomized mice Arthritis Rheum. 2008;58 Suppl. (9): S646-S646
Krönke G, Katzenbeisser J, Uderhardt S, Baum W, Axmann R, Zwerina J, Schett G: 12/15-lipoxygenase is involved in the limitation of inflammation and tissue damage in murine arthritis Wien Klin Wochenschr. 2008;120 Suppl.(): 37-37

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