Medizin 3

Publikationen: Prof. Dr. rer. nat. M. Zaiss

Zaiss MM: HOW THE GUT MICROBIOTA AND ITS METABOLITES IMPACT ON BONE HOMEOSTASIS Ann Rheum Dis. 2018;77(): 38-38
Lucas S, Omata Y, Hofmann J, Böttcher M, Iljazovic A, Sarter K, Albrecht O, Schulz O, Krishnacoumar B, Krönke G, Herrmann M, Mougiakakos D, Strowig T, Schett G, Zaiss MM: Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nat Commun. 2018;9(1): 55
Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM: Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018;24(1): 169-180
Lucas S, Omata Y, Boettcher M, Hofmann J, Krishnacoumar B, Kroenke G, Mougiakakos D, Iljazovic A, Sonnewald U, Strowig T, Schett G, Zaiss M: Short chain fatty acids are potent regulators of systemic bone mass and protect for pathological bone loss by inhibiting osteoclasts Eur J Immunol. 2017;47(): 217-217
Ackermann JA, Hofheinz K, Zaiss MM, Krönke G: The double-edged role of 12/15-lipoxygenase during inflammation and immunity. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(4): 371-381
Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Bozec A, Herrmann M, Zaiss M, Fearon U, Veale DJ, Canete J, Distler O, Rivellese F, Pitzalis C, Schett G, Distler J, Ramming A: IL-9-Producing Innate Lymphoid Cells - Keyplayers That Orchestrate Resolution of Chronic Inflammation in Arthritis Arthritis Rheumatol. 2017;69():
Sarter K, Kulagin M, Schett G, Harris NL, Zaiss MM: Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites. Autoimmunity. 2017;50(3): 151-157
Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A: Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017;23(8): 938-944
Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP: Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis. Cell Death Differ. 2017;24(4): 672-682
Omata Y, Lucas S, Garcia M, Wirtz S, Bozec A, Schett G, Zaiss MM: REGULATION OF ARTHRITIS BY TYPE 2 INNATE LYMPHOID CELLS Ann Rheum Dis. 2017;76 1(): A3-A3
Bozec A, Zaiss MM: T Regulatory Cells in Bone Remodelling. Curr Osteoporos Rep. 2017;15(3): 121-125
Zaiss MM, Harris NL: Interactions between the intestinal microbiome and helminth parasites. Parasite Immunol. 2016;38(1): 5-11
Mosconi I, Dubey LK, Volpe B, Esser-von Bieren J, Zaiss MM, Lebon L, Massacand JC, Harris NL: Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection. Infect Immun. 2015;83(9): 3657-65
Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, McCoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL: The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity. 2015;43(5): 998-1010
Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS: Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS ONE. 2014;9(1): e84818
Bozec A, Zaiss MM, Kagwiria R, Voll R, Rauh M, Chen Z, Mueller-Schmucker S, Kroczek RA, Heinzerling L, Moser M, Mellor AL, David JP, Schett G: T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway. Sci Transl Med. 2014;6(235): 235ra60
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G: PPAR?/? governs Wnt signaling and bone turnover. Nat Med. 2013;19(5): 608-13
Zwerina K, Koenders M, Hueber A, Marijnissen RJ, Baum W, Heiland GR, Zaiss M, McLnnes I, Joosten L, van den Berg W, Zwerina J, Schett G: Anti IL-17A therapy inhibits bone loss in TNF-?-mediated murine arthritis by modulation of the T-cell balance. Eur J Immunol. 2012;42(2): 413-23
Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G, David JP: RSK2 protects mice against TNF-induced bone loss. J Cell Sci. 2012;125(Pt 9): 2160-71
Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY, Schett G: IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-{alpha}-Mediated Bone Loss. J Immunol. 2011;186(11): 6097-105
Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G, David JP: Elevated Fra-1 expression causes severe lipodystrophy. J Cell Sci. 2011;124(Pt 9): 1465-76
Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K, Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS, Gessner A, Schett G, Amling M, McKenzie AN, Horst AK, Schinke T: Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells. J Bone Miner Res. 2011;26(4): 704-17
Gückel E, Frey S, Zaiss MM, Schett G, Ghosh S, Voll RE: Cell-intrinsic NF-?B activation is critical for the development of natural regulatory T cells in mice. PLoS ONE. 2011;6(5): e20003
Krönke G, Uderhardt S, Kim KA, Stock M, Scholtysek C, Zaiss MM, Surmann-Schmitt C, Luther J, Katzenbeisser J, David JP, Abdollahi-Roodsaz S, Tran K, Bright JM, Binnerts ME, Akhmetshina A, Böhm C, Distler JH, Joosten LA, Schett G, Abo A: R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum. 2010;62(8): 2303-12
Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hünig T, Schett G, David JP: Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol. 2010;184(12): 7238-46
Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schütz G, Tuckermann JP: Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010;11(6): 517-31
Böhm C, Zaiss MM, Axmann R, Hess A, Engelke K, Kollias G, Schett G, David JP: ERK- ACTIVATED KINASE RSK2 PROTECTS AGAINST INFLAMMATORY ARTHRITIS- INDUCED BONE DESTRUCTION BY OPPOSING THE TUMOUR NECROSIS FACTOR alpha- MEDIATED INHIBITION OF BONE FORMATION Ann Rheum Dis. 2010;69 Suppl. (): A60 -
Zaiss MM, Sarter K, Hess A, Engelke K, Böhm C, Nimmerjahn F, Voll R, Schett G, David JP: Increased bone density and resistance to ovariectomy-induced bone loss in FoxP3-transgenic mice based on impaired osteoclast differentiation. Arthritis Rheum. 2010;62(8): 2328-38
Frey B, Gaipl US, Sarter K, Zaiss MM, Stillkrieg W, Rödel F, Schett G, Herrmann M, Fietkau R, Keilholz L: Whole body low dose irradiation improves the course of beginning polyarthritis in human TNF-transgenic mice. Autoimmunity. 2009;42(4): 346-8
Krönke G, Katzenbeisser J, Uderhardt S, Zaiss MM, Scholtysek C, Schabbauer G, Zarbock A, Koenders MI, Axmann R, Zwerina J, Baenckler HW, van den Berg W, Voll RE, Kuhn H, Joosten LA, Schett G: 12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol. 2009;183(5): 3383-9
Böhm C, Hayer S, Kilian A, Zaiss MM, Finger S, Hess A, Engelke K, Kollias G, Krönke G, Zwerina J, Schett G, David JP: The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol. 2009;183(9): 5938-47
Zaiss M, Axmann R, Zwerina J, Polzer K, Gückel E, Skapenko A, Schulze-Koops H, Horwood N, Cope A, Schett G: Regulatory T cells suppress osteoclast formation: A new link between the immune system and bone Ann Rheum Dis. 2008;67 Suppl. (): 095 -
Axmann R, Herman S, Zaiss M, Franz S, Polzer K, Zwerina J, Herrmann M, Smolen J, Schett G: CTLA-4 directly inhibits osteoclast formation. Ann Rheum Dis. 2008;67(11): 1603-9
Zaiss MM, Axmann R, Zwerina J, Polzer K, Gückel E, Skapenko A, Schulze-Koops H, Horwood N, Cope A, Schett G: Treg cells suppress osteoclast formation: A new link between the immune system and bone. Arthritis Rheum. 2007;56(12): 4104-12