Science and patient communication

Doctor-patient communication: CARSLE VR App – Fighting Lupus

CARSLE VR – Fighting Lupus is an innovative educational tool that conveys knowledge on CAR T-cell therapy for systemic lupus erythematosus (SLE), polymyositis, and systemic sclerosis. The virtual reality (VR) application guides users on an immersive journey through the human body, making complex disease mechanisms and therapeutic strategies tangible and easy to understand.

In addition to a medically supervised mode, the platform includes a standalone single-player version, making it well suited for use in educational settings. An ongoing clinical study evaluates the potential of immersive learning to enhance patient education, support doctor–patient communication, and strengthen patients’ confidence in informed decision-making.

INFLAMMANIA 3D on Roblox

Inflammania 3D – The Inflammation Game is an interactive 3D platform built on the widely used Roblox engine, designed to translate current research in inflammation into engaging digital experiences. In the immersive environment Catch me if you can - The CAR T cell Solution", users become part of the immune system and apply innovative CAR T-cell therapies to eliminate autoreactive B cells, illustrating therapeutic principles in autoimmune diseases such as systemic lupus erythematosus. Play the game “Catch me if you can - The CAR T cell Solution”

The platform is based on a prototype originally developed within the Sonderforschungsbereich (SFB) 1181 „Schaltstellen zur Auflösung von Entzündung“ (2015–2024) and is currently being further expanded and refined within the SFB 1755 CASCAID in collaboration with the Chair of Business Information Systems at the University of Bamberg. This ongoing development focuses on scaling immersive learning experiences and enhancing their educational and scientific impact.

A second game, “SteamScavenger: Empower macrophages" , allows players to take on the role of macrophages, making strategic decisions to regulate inflammatory processes. The game exemplifies how complex biological mechanisms can be conveyed in an accessible and motivating way. Play the game “SteamScavenger - Empower Macrophages”

Together, these applications demonstrate the potential of gamified, immersive formats to communicate sophisticated immunological concepts effectively to younger audiences and the broader public.

INFLAMMANIA - The Inflammation Game - Fight to Cure

Inflammania is a digital tower defence game that provides an engaging and educational experience by introducing players to the complexities of the immune system. In the event of a gout attack, it is recommended that neutrophils are deployed to combat uric acid crystals. In addition, further information on the role of antibodies in regulating asthma and chronic inflammation, including rheumatism and Crohn's disease, is available. The game offers an engaging and informative way to understand complex molecular processes and emphasises the significance of early diagnosis. www.inflammania.de

INFLAMMANIA 2 - The Inflammation Game - Fight to Cure

Inflammania 2 is a game similar to Plants vs. Zombies, in which players learn how the body defends itself against bacterial, parasitic and COVID-19 infections. Employ targeted defence mechanisms to combat bacteria, hookworms and the coronavirus, while acquiring knowledge on the functionality of mRNA vaccines. The game is an ideal resource for individuals with an interest in medicine, offering a clear explanation of the development of chronic inflammation, the mechanisms of action of medicines, and the influence of lifestyle changes on disease activity. www.inflammania.de

1. Wie Gamification kranken Menschen helfen kann. BR Rundfunk. www.ardmediathek.de/video/frankenschau-aktuell/wie-gamification-kranken-menschen-helfen-kann/br/Y3JpZDovL2JyLmRlL2Jyb2FkY2FzdFNjaGVkdWxlU2xvd
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2. FAU Magazin. Zwei gegen Wolf – Spielerisch über schwere Krankheiten aufklären und neue Wege in der Patientenkommunikation eröffnen: Das kann die App „Fighting Lupus“, die von Sandra Jeleazcov und Benedikt Morschheuser entwickelt wurde. 2024. www.fau.de/2024/11/magazine/fau-magazin-2024/innovation-2024/zwei-gegen-wolf/
3. Jeleazcov S. INFLAMMANIA - Fight to Cure: Neue Wege der Wissenschaftskommunikation. Lecture / Webinar. Lange Nacht der Wissenschaft. Deutsches Zentrum Immuntherapie. 2023. youtu.be/FSMCTacL8Js. Erlangen, Germany
4. Greiner R, Merk S, Reiß S, Stief J, Wüllner C, Morschheuser B, Jeleazcov S. Inflammania 3D: Exploring the Use of the Metaverse Platform Roblox for Science Communication. Poster presentation at 7th Annual International GamiFIN Conference 2023, Lapland, FI. https://open.fau.de/handle/openfau/23201
5. Jeleazcov S, Bogdan C, Morschheuser B. (2022) Körper in Flammen – spielend gegen Entzündungen. Video. Friedrich-Alexander-Universität Erlangen-Nürnberg. youtu.be/u2whMu_RAq4
6. Jeleazcov S, Scherbel C, Rauner M. Osteoimmunologie – revisited: Neue Einblicke in das Wechselspiel von Immunsystem und Knochen. Osteologie. 2014. doi: 10.1055/s-0037-1622020.
7. Siggelkow H, Jeleazcov S. Osteoporose? Chronische Krankheiten im Fokus der Gendermedizin-spezifischen Betrachtung. In Kloepfer M., Kloepfer A., Kurscheid C (Hrsg): Jahrbuch Gendergesundheit 2014. ISBN 978-3-86216-149-2. 

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