PD Dr. U. Steffen (formerly Harre)

Publications: Dr. U. Steffen (formerly Harre)

Falck D, Sokolova MV, Koeleman CAM, Irumva V, Kirchner P, Schulz SR, Schmidt KG, Harrer T, Ekici AB, Spriewald B, Schett G, Wuhrer M, Herrmann M, Steffen U: IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression. Cell Commun Signal. 2025;23(1):
Krishnacoumar B, Stenzel M, Garibagaoglu H, Omata Y, Sworn RL, Hofmann T, Ipseiz N, Czubala MA, Steffen U, Maccataio A, Stoll C, Böhm C, Herrmann M, Uderhardt S, Jenkins RH, Taylor PR, Grüneboom A, Zaiss MM, Schett G, Krönke G, Scholtysek C: Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors. Bone Res. 2024;12(1):
Sokolova MV, Hartmann F, Sieghart D, Bang H, Steiner G, Kleyer A, Schett G, Steffen U: Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk. RMD Open. 2023;9(1):
Mes L, Steffen U, Chen HJ, Veth J, Hoepel W, Griffith GR, Schett G, den Dunnen J: IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells. Front Immunol. 2023;14():
Zlatar L, Mahajan A, Muñoz-Becerra M, Weidner D, Bila G, Bilyy R, Titze J, Hoffmann MH, Schett G, Herrmann M, Steffen U, Muñoz LE, Knopf J: Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis. Front Immunol. 2023;14():
Almenara-Fuentes L, Rodriguez-Fernandez S, Rosell-Mases E, Kachler K, You A, Salvado M, Andreev D, Steffen U, Bang H, Bozec A, Schett G, Le Panse R, Verdaguer J, Dalmases M, Rodriguez-Vidal S, Barneda-Zahonero B, Vives-Pi M: A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens. Nanomedicine. 2023;48():
Sokolova MV, Hagen M, Bang H, Schett G, Rech J, Steffen U, RETRO study group.: IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis. Rheumatology (Oxford). 2022;61(5): 2124-2131
Sokolova MV, Schett G, Steffen U: Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings. Clin Rev Allergy Immunol. 2022;63(2): 138-151
Simon D, Tascilar K, Schmidt K, Manger B, Weckwerth L, Sokolova M, Bucci L, Fagni F, Manger K, Schuch F, Ronneberger M, Hueber A, Steffen U, Mielenz D, Herrmann M, Harrer T, Kleyer A, Krönke G, Schett G: Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion. Arthritis Rheumatol. 2022;74(1): 33-37
Gimpel AK, Maccataio A, Unterweger H, Sokolova MV, Schett G, Steffen U: IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes. Front Immunol. 2022;12():
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH: The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity. 2021;54(5): 1002-1021.e10
Andes FT, Adam S, Hahn M, Aust O, Frey S, Grueneboom A, Nitschke L, Schett G, Steffen U: The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption. Bone. 2021;143():
Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM: A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. J Exp Med. 2021;218(1):
Steffen U, Koeleman CA, Sokolova MV, Bang H, Kleyer A, Rech J, Unterweger H, Schicht M, Garreis F, Hahn J, Andes FT, Hartmann F, Hahn M, Mahajan A, Paulsen F, Hoffmann M, Lochnit G, Munoz LE, Wuhrer M, Falck D, Herrmann M, Schett G: IgA subclasses have different effector functions associated with distinct glycosylation profiles. Nat Commun. 2020;11(1):
Vergarajauregui S, Becker R, Steffen U, Sharkova M, Esser T, Petzold J, Billing F, Kapiloff MS, Schett G, Thievessen I, Engel FB: AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9. Elife. 2020;9():
Staats LAN, Pfeiffer H, Knopf J, Lindemann A, Fürst J, Kremer AE, Hackstein H, Neurath MF, Muñoz LE, Achenbach S, Leppkes M, Herrmann M, Schett G, Steffen U: IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients. Cells. 2020;9(12):
Andreev D, Liu M, Weidner D, Kachler K, Faas M, Grüneboom A, Schlötzer-Schrehardt U, Muñoz LE, Steffen U, Grötsch B, Killy B, Krönke G, Luebke AM, Niemeier A, Wehrhan F, Lang R, Schett G, Bozec A: Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin. J Clin Invest. 2020;130(9): 4811-4830
Azizov V, Dietel K, Steffen F, Dürholz K, Meidenbauer J, Lucas S, Frech M, Omata Y, Tajik N, Knipfer L, Kolenbrander A, Seubert S, Lapuente D, Sokolova MV, Hofmann J, Tenbusch M, Ramming A, Steffen U, Nimmerjahn F, Linker R, Wirtz S, Herrmann M, Temchura V, Sarter K, Schett G, Zaiss MM: Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis. Nat Commun. 2020;11(1):
Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ: JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function. Sci Transl Med. 2020;12(530):
Azizov V, Dietel K, Kolenbrander A, Seubert S, Steffen F, Meidenbauer J, Steffen U, Hofmann J, Nimmerjahn F, Linker R, Wirtz S, Sarter K, Herrmann M, Temchura V, Schett G, Zaiss M: Ethanol consumption decreases autoantibody titers by blocking IL-21 secretion of Tfh cells during the development of arthritis Eur J Immunol. 2019;49(): 199-199
Azizov V, Dietel K, Kolenbrander A, Seubert S, Steffen F, Meidenbauer J, Steffen U, Hofmann J, Nimmerjahn F, Linker R, Wirtz S, Herrmann M, Sarter K, Temchura V, Schett G, Zaiss M: Ethanol consumption inhibits the development of autoimmunity by blocking IL-21 secretion in T-FH cells Eur J Immunol. 2019;49(): 936-936
Andes F, Zapf J, Hahn J, Manger B, Schett G, Steffen U: HIGHER EXPRESSION OF SIGLEC-7/9 ON GRANULOCYTES AND MONOCYTES HAS A PROTECTIVE ROLE IN RHEUMATOID ARTHRITIS Ann Rheum Dis. 2019;78(): A65-A66
Adam S, Simon N, Steffen U, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITION BY BARICITINIB AND TOFACITINIB AMELIORATES PATHOLOGICAL BONE LOSS Ann Rheum Dis. 2019;78(): A65-A65
Steffen U, Andes FT, Schett G: Generation and Analysis of Human and Murine Osteoclasts. Curr Protoc Immunol. 2019;125(1):
Adam S, Simon N, Steffen U, Harre N, Andes F, Mueller D, Culemann S, Andreev D, Hahn M, Scholtysek C, Schett G, Kroenke G, Frey S, Hueber A: JAK-INHIBITORS TOFACITINIB AND BARICITINIB IMPROVE PATHOLOGICAL BONE LOSS IN VIVO Ann Rheum Dis. 2019;78(): 110-110
Haeger J, Bang H, Hagen M, Frech M, Traeger P, Sokolova MV, Steffen U, Tascilar K, Sarter K, Schett G, Rech J, Zaiss MM: The Role of Dietary Fiber in Rheumatoid Arthritis Patients: A Feasibility Study Nutrients. 2019;11(10):
Steffen U, Schett G, Bozec A: How Autoantibodies Regulate Osteoclast Induced Bone Loss in Rheumatoid Arthritis Front Immunol. 2019;10():
Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G: Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin. J Bone Miner Res. 2018;33(12): 2243-2243
Hauser B, Harre U: The Role of Autoantibodies in Bone Metabolism and Bone Loss Calcif Tissue Int. 2018;102(5): 522-532
Engdahl C, Bondt A, Harre U, Raufer J, Pfeifle R, Camponeschi A, Wuhrer M, Seeling M, Mårtensson IL, Nimmerjahn F, Krönke G, Scherer HU, Forsblad-d'Elia H, Schett G: Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women. Arthritis Res Ther. 2018;20(1):
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol. 2017;18(1): 104-113
Lang SC, Harre U, Purohit P, Dietel K, Kienhöfer D, Hahn J, Baum W, Herrmann M, Schett G, Mielenz D: Neurodegeneration Enhances the Development of Arthritis. J Immunol. 2017;198(6): 2394-2402
Chakraborty S, Kloos B, Harre U, Schett G, Kubatzky KF: Pasteurella multocida Toxin Triggers RANKL-Independent Osteoclastogenesis. Front Immunol. 2017;8(): 185
Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G: Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin. J Bone Miner Res. 2017;32(8): 1681-1691
Harre U, Schett G: Cellular and molecular pathways of structural damage in rheumatoid arthritis. Semin Immunopathol. 2017;39(4): 355-363
Huang J, Maier C, Zhang Y, Soare A, Dees C, Beyer C, Harre U, Chen CW, Distler O, Schett G, Wollin L, Distler JHW: Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis. Ann Rheum Dis. 2017;76(11): 1941-1948
Simon D, Derer A, Andes FT, Lezuo P, Bozec A, Schett G, Herrmann M, Harre U: Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone. 2017;105(): 35-41
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Hueber AJ, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: NOVEL MECHANISM MEDIATED BY THE IL23/TH17 AXIS CONTRIBUTING TO AUTO-IMMUNE ARTHRITIS Ann Rheum Dis. 2017;76 1(): A6-A7
Pfeifle R, Rothe T, Ipseiz N, Culemann S, Harre U, Schett G, Kroenke G: Novel mechanism mediated by the IL23/Th17 axis contributing to auto-immune arthritis Eur J Immunol. 2017;47(): 141-141
Engdahl C, Raufer J, Harre U, Bondt A, Pfeifle R, Kroenke G, Scherer HU, Forsblad H, Schett G: ESTROGEN INFLUENCES THE SIALYLATION PROFILE AND INFLAMMATORY PROPERTIES OF ANTIBODIES - A POTENTIAL EXPLANATION FOR THE SEX DIFFERENCES AND INCREASED RISK FOR RA IN POSTMENOPAUSAL WOMEN Ann Rheum Dis. 2017;76(): 775-775
Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G: Periarticular Bone Loss in Arthritis Is Induced By Autoantibodies Against Citrullinated Vimentin Arthritis Rheumatol. 2016;68():
Pfeifle R, Rothe T, Ipseiz N, Culemann S, Harre U, Kroenke G, Schett G: Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis Arthritis Rheumatol. 2016;68():
Harre U, Schett G: [Association between bone catabolism and anti-citrullinated protein antibodies in rheumatoid arthritis]. Z Rheumatol. 2016;75(8): 809-811
Harre U, Lang SC, Pfeifle R, Rombouts Y, Frühbeißer S, Amara K, Bang H, Lux A, Koeleman CA, Baum W, Dietel K, Gröhn F, Malmström V, Klareskog L, Krönke G, Kocijan R, Nimmerjahn F, Toes RE, Herrmann M, Scherer HU, Schett G: Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun. 2015;6(): 6651
Kloos B, Chakraborty S, Lindner SG, Noack K, Harre U, Schett G, Krämer OH, Kubatzky KF: Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. Cell Commun Signal. 2015;13(1): 40
Arnold ML, Fuernrohr BG, Weiß KM, Harre U, Wiesener MS, Spriewald BM: Association of a coding polymorphism in Fc gamma receptor 2A and graft survival in re-transplant candidates. Hum Immunol. 2015;76(10): 759-64
Harre U, Kittan NA, Schett G: Autoantibody-mediated bone loss. Curr Osteoporos Rep. 2014;12(1): 17-21
Ossipova E, Cerqueira CF, Reed E, Kharlamova N, Israelsson L, Holmdahl R, Nandakumar KS, Engström M, Harre U, Schett G, Catrina AI, Malmström V, Sommarin Y, Klareskog L, Jakobsson PJ, Lundberg K: Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint. Arthritis Res Ther. 2014;16(4): R167
Derer A, Groetsch B, Harre U, Böhm C, Towne J, Schett G, Frey S, Hueber AJ: Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis. PLoS ONE. 2014;9(8): e101954
Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araújo E, Hueber AJ, Harre U, Engelke K, Schett G: Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014;73(5): 854-60
Harre U, Georgess D, Axmann R, Bang H, Toes R, Scherer HU, Catrina A, Klareskog L, Jurdic P, Schett G: ANTI-CITRULLINATED PROTEIN ANTIBODIES DIRECTLY INDUCE BONE LOSS IN RHEUMATOID ARTHRITIS Ann Rheum Dis. 2013;71 Suppl 3(): 59-59
Krishnamurthy A, Pomiano NV, Cerqueira C, Ossipova E, Lundberg K, Harre U, Malmstrom V, Jakobsson PJ, Klareskog L, Schett G, Catrina AI: Anti Citrullinated Protein Antibodies from Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis Ann Rheum Dis. 2013;72 Suppl 1(): A57-A58
Pfeifle R, Magorivska I, Scherer U, Harre U, Rothe T, Bohm S, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G: IL23/TH17-MEDIATED REGULATION OF ANTIBODY GLYCOSYLATION CONTROLS AUTOIMUNE-INDUCED ARTHRITIS Ann Rheum Dis. 2013;72 1(): A13-A13
Harre U, Pfeifle R, Lux A, Fruhbeisser S, Grohn F, Krönke G, Nimmerjahn F, Herrmann M, Schett G: Fc-GLYCOSYLATION DETERMINES OSTEOCLASTOGENIC ACTIVITY OF IMMUNE COMPLEXES Ann Rheum Dis. 2013;72 1(): A58-A58
Kocijan R, Harre U, Schett G: ACPA and bone loss in rheumatoid arthritis. Curr Rheumatol Rep. 2013;15(10): 366
Harre U, Schett G: Bone research in 2012: the ups and downs of bone in health and rheumatic disease. Nat Rev Rheumatol. 2013;9(2): 67-8
Harre U, Keppeler H, Ipseiz N, Derer A, Poller K, Aigner M, Schett G, Herrmann M, Lauber K: Moonlighting osteoclasts as undertakers of apoptotic cells. Autoimmunity. 2012;45(8): 612-9
Krishnamurthy A, Pomiano NV, Cerqueira C, Ossipova E, Lundberg K, Harre U, Malmstrom V, Jakobsson PJ, Klareskog L, Schett G, Catrina AI: Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis Arthritis Rheum. 2012;64 Suppl S(10): S12-S12
Finzel S, Lang V, Kleyer A, Rech J, Manger B, Araujo E, Hueber AJ, Harre U, Schett G: Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies. Arthritis Rheum. 2012;64(10): S437-S437
Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P, Schett G: Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012;122(5): 1791-802
Harre U, Derer A, Schorn C, Schett G, Herrmann M: T cells as key players for bone destruction in gouty arthritis? Arthritis Res Ther. 2011;13(6): 135

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Publications: Dr. U. Steffen (formerly Harre)

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